A5103239040- Chronic Obstructive Pulmonary Disease (COPD) Research
- Obstructive Sleep Apnea Research
- Respiratory Support and Mechanisms
- Neuroscience of respiration and sleep
- Asthma and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiovascular and Diving-Related Complications
- Tracheal and airway disorders
- Pulmonary Hypertension Research and Treatments
- Inhalation and Respiratory Drug Delivery
- Respiratory and Cough-Related Research
- Neonatal Respiratory Health Research
- Cardiovascular and exercise physiology
- Sarcoidosis and Beryllium Toxicity Research
- Lung Cancer Treatments and Mutations
- Cardiovascular Disease and Adiposity
- Sleep and Wakefulness Research
- Cancer Genomics and Diagnostics
- Pediatric health and respiratory diseases
- Medical Imaging and Pathology Studies
- Nutrition and Health Studies
- Pleural and Pulmonary Diseases
- Protease and Inhibitor Mechanisms
- Sleep and related disorders
- High Altitude and Hypoxia
Chiesi (France)
2024
Celon Pharma (Poland)
2024
Leo Pharma (Germany)
2024
Novartis (Switzerland)
2024
Sanofi (France)
2024
Novartis (Netherlands)
2024
Menarini Group (Germany)
2024
Boehringer Ingelheim (Portugal)
2024
Ege University
2024
Instytut Gruźlicy i Chorób Płuc
2008-2023
This document provides clinical recommendations for treatment of chronic obstructive pulmonary disease (COPD) exacerbations. Comprehensive evidence syntheses, including meta-analyses, were performed to summarise all available relevant the Task Force's questions. The was appraised using Grading Recommendations, Assessment, Development and Evaluation approach results summarised in profiles. syntheses discussed formulated by a multidisciplinary Force COPD experts. After considering balance...
Percutaneous renal sympathetic denervation by radiofrequency energy has been reported to reduce blood pressure (BP) the reduction of efferent and afferent signaling. We evaluated effects this procedure on BP sleep apnea severity in patients with resistant hypertension apnea. studied 10 refractory (7 men 3 women; median age: 49.5 years) who underwent completed 3-month 6-month follow-up evaluations, including polysomnography selected chemistries, measurements. Antihypertensive regimens were...
BACKGROUND: To date only two controlled studies have been published on the effects of domiciliary oxygen treatment survival in patients with chronic obstructive pulmonary disease (COPD) advanced respiratory failure. The such despite remains poor. prescription long term therapy (LTOT) less severe controversial. aim this study was to evaluate rationale for prescribing COPD moderate hypoxaemia. METHODS: One hundred and thirty five COPD, PaO2 7.4-8.7 kPa (56-65 mmHg) airflow limitation (mean...
Aliverti, A., S. J. Cala, R. Duranti, G. Ferrigno, C. M. Kenyon, A. Pedotti, Scano, P. Sliwinski, Peter T. Macklem, and Yan. Human respiratory muscle actions control during exercise. Appl. Physiol. 83(4): 1256–1269, 1997.—We measured pressures power of diaphragm, rib cage, abdominal muscles quiet breathing (QB) exercise at 0, 30, 50, 70% maximum workload (W˙max) in five men. By three-dimensional tracking 86 chest wall markers, we calculated the volumes lung- diaphragm-apposed cage...
The inspiratory capacity (IC) maneuver is increasingly used to monitor exercise-induced dynamic hyperinflation in patients with COPD. However, the reliability of this method COPD exercising symptom limitation has not been systematically studied and presented. purpose present study was therefore evaluate IC assessing changes end-expiratory lung volume (EELV) by pressure developed during maneuvers, incremental bicycle exercise exhaustion. Fifteen stable performed limitation. During experiment,...
Although it has been postulated that central inhibition of respiratory drive may prevent development diaphragm fatigue in patients with chronic obstructive pulmonary disease (COPD) during exercise, this premise not validated. We evaluated electrical activation (EAdi) relative to maximum 10 moderately severe COPD at rest and incremental exhaustive bicycle exercise. Flow was measured a pneumotachograph volume by integration flow. EAdi transdiaphragmatic pressures (Pdi) were using an esophageal...
This document provides clinical recommendations for the prevention of chronic obstructive pulmonary disease (COPD) exacerbations. It represents a collaborative effort between European Respiratory Society and American Thoracic Society. Comprehensive evidence syntheses were performed to summarise all available relevant Task Force9s questions. The was appraised using Grading Recommendations, Assessment, Development Evaluation approach results summarised in profiles. discussed formulated by...
Multiple intergenic single-nucleotide polymorphisms (SNPs) near hedgehog interacting protein (HHIP) on chromosome 4q31 have been strongly associated with pulmonary function levels and moderate-to-severe chronic obstructive disease (COPD). However, whether the effects of variants in this region are related to HHIP or another gene has not proven. We confirmed genetic association SNPs COPD genome-wide study (GWAS) a Polish cohort containing severe cases healthy smoking controls (P = 0.001...
Systemic hypertension is associated with obstructive sleep apnoea syndrome (OSAS) but the pathophysiological mechanisms are incompletely understood. A collaborative European network of 24 centres established a Sleep Apnoea Database to evaluate cardiovascular morbidity OSAS. 11 911 adults referred suspected OSAS between March 2007 and September 2013 underwent overnight studies, either cardiorespiratory polygraphy or polysomnography. We compared predictive value apnoea–hypopnoea index (AHI) 4%...
Clinical presentation phenotypes of obstructive sleep apnoea (OSA) and their association with comorbidity as well impact on adherence to continuous positive airway pressure (CPAP) treatment have not been established.A prospective follow-up cohort adult patients OSA (apnoea-hypopnoea index (AHI) ≥5/h) from 17 European countries Israel (n = 6,555) was divided into four clinical based daytime symptoms labelled excessive sleepiness ("EDS") nocturnal problems other than (labelled "insomnia"): 1)...
The European Sleep Apnoea Database (ESADA) reflects a network of 22 sleep disorder centres in Europe enabled by COST action B26 programme. This ongoing project aims to describe differences standard clinical care patients with obstructive apnoea (OSA) and establish resource for genetic research this disorder. Patients suspected OSA are consecutively included followed up according local standards. Anthropometrics, medical history, medication, daytime symptoms data (polysomnography or...
The analysis of plasma cell-free DNA (cfDNA) is expected to provide useful biomarkers for early diagnosis non-small-cell lung cancer (NSCLC). However, it remains unclear whether the intense release cfDNA into bloodstream NSCLC patients results from malignancy or chronic inflammatory response. Consequently, current diagnostic utility quantification has not been thoroughly validated in subjects with respiratory inflammation. Here we assess effect inflammation on levels and evaluate potential...
It has been postulated that catheter-based renal denervation (RDN) may lower blood pressure (BP) and improve severity of obstructive sleep apnea (OSA) in resistant hypertensive patients. The aim our study (NCT01366625) was to investigate a prospective randomized trial the effect RDN on BP clinical course OSA. Sixty patients with true hypertension coexisting moderate-to-severe OSA (apnea/hypopnea index, ≥15) were randomly allocated group (30 patients) control patients). primary end point...
New findings on pathophysiology, epidemiology, and outcome have raised concerns the relevance of apnoea–hypopnoea index (AHI) in classification obstructive sleep apnoea (OSA) severity. Recently, a multicomponent grading system decision integrating symptomatology comorbidities (Baveno classification), was proposed to characterise OSA guide therapeutic decisions. We evaluated whether this reflects population, it translates into differences outcomes, addition AHI improves scheme. A total 14 499...
The efficacy and safety of twice-daily aclidinium bromide/formoterol fumarate was compared with that salmeterol/fluticasone propionate in patients stable, moderate-to-severe chronic obstructive pulmonary disease (COPD). AFFIRM COPD (Aclidinium Formoterol Findings Respiratory Medicine COPD) a 24-week, double-blind, double-dummy, active-controlled study. Patients were randomised (1:1) to aclidinium/formoterol 400/12 µg via Genuair/Pressair or 50/500 Accuhaler. primary end-point peak forced...
Obstructive sleep apnoea (OSA) is associated with increased risk of dysglycaemia but the intimate link these conditions obesity makes discerning an independent relationship between them challenging. Glycosylated haemoglobin (HbA1c) levels predict adverse cardiovascular outcomes in nondiabetics there a lack population-level data exploring HbA1c OSA. A cross-sectional analysis 5294 participants multinational European Sleep Apnoea Cohort (European Database) study was performed, assessing OSA...
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To understand how externally applied expiratory flow limitation (EFL) leads to impaired exercise performance and dyspnea, we studied six healthy males during control incremental exhaustion (C) with EFL at approximately 1. We measured volume the mouth (Vm), esophageal, gastric transdiaphragmatic (Pdi) pressures, maximal power (W(max)) difference (Delta) in Borg scale ratings of breathlessness between C exercise. Optoelectronic plethysmography chest wall lung (VL). From Campbell diagrams,...