A5058492122- Obstructive Sleep Apnea Research
- Sleep and Wakefulness Research
- Neuroscience of respiration and sleep
- Sleep and related disorders
- Heart Rate Variability and Autonomic Control
- Non-Invasive Vital Sign Monitoring
- EEG and Brain-Computer Interfaces
- Sleep and Work-Related Fatigue
- Cardiovascular Syncope and Autonomic Disorders
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Restless Legs Syndrome Research
- Circadian rhythm and melatonin
- Biomedical and Chemical Research
- Health and Medical Studies
- Cardiovascular and Diving-Related Complications
- Tracheal and airway disorders
- Phonocardiography and Auscultation Techniques
- Complex Systems and Time Series Analysis
- ECG Monitoring and Analysis
- COVID-19 and Mental Health
- Airway Management and Intubation Techniques
- Neural dynamics and brain function
- Time Series Analysis and Forecasting
- Context-Aware Activity Recognition Systems
Charité - Universitätsmedizin Berlin
2016-2025
Humboldt-Universität zu Berlin
1993-2024
Saratov State University
2020-2023
Freie Universität Berlin
2018-2023
Hospital de São João
2023
Universidade do Porto
2023
Antwerp University Hospital
2022
University of Antwerp
2022
Turku University Hospital
2012-2022
Spitalul Clinic Dr. Victor Babes
2022
The 1968 Rechtschaffen and Kales (R & K) sleep scoring manual was published 15 years after REM discovered. Advances in the ensuing 28 warranted a re-look at visual of stages. This paper describes work AASM Visual Scoring Task Force, including methodology, literature review rationale behind new rules. Reliability studies R K were reviewed; reliability low for stage one moderate slow wave sleep. Evidence indicated that complexes waves are expressed maximal frontally, spindles centrally alpha...
How did the study come about?Although in past century mortality West Germany decreased similarly as other Western nations, these changes were less pronounced East Germany. 1,2After German reunification 1990, there was a lack of scientifically valid data from to explain regional differences life expectancy and, consequently, need for population-based research northeast
There is increasing evidence that obstructive sleep apnea (OSA) an independent risk factor for arterial hypertension. Because there are no controlled studies showing a substantial effect of nasal continuous positive airway pressure (nCPAP) therapy on hypertension in OSA, the impact treatment cardiovascular sequelae has been questioned altogether. Therefore, we studied nCPAP patients with OSA.Sixty consecutive moderate to severe OSA were randomly assigned either effective or subtherapeutic 9...
Healthy sleep consists of several stages: deep sleep, light and rapid eye movement (REM) sleep. Here we show that these stages can be characterized distinguished by correlations heart rates separated $n$ beats. Using the detrended fluctuation analysis (DFA) up to fourth order find long-range reminiscent wake phase are present only in REM phase. In non-REM phases, uncorrelated above typical breathing cycle time, pointing a random regulation heartbeat during
Sleep has been regarded as a testing situation for the autonomic nervous system, because its activity is modulated by sleep stages. Sleep-related breathing disorders also influence system and can cause heart rate changes known cyclical variation. We investigated effect of stages apnea on analyzing variability (HRV). Since spectral analysis suited identification variations detrended fluctuation analyze scaling behavior detect long-range correlations, we compared results both complementary...
Abstract Identification of obstructive sleep apnea and risk factors is important for reduction in symptoms cardiovascular risk, improvement quality life. The population‐based Study Health Pomerania investigated clinical diseases a general population northeast Germany. Additional polysomnography was applied to measure respiration with the objective assessing prevalence German cohort. One‐thousand, two‐hundred eight people between 20 81 years old (54% men, median age 54 years) underwent...
Integrated physiological systems, such as the cardiac and respiratory system, exhibit complex dynamics that are further influenced by intrinsic feedback mechanisms controlling their interaction. To probe how system adjust rhythms, despite continuous fluctuations in dynamics, we study phase synchronization of heartbeat intervals cycles. The nature this interaction, its clinical relevance, relation to neural control is not well understood. We investigate whether cardiorespiratory (CRPS)...
A recent study of patients with moderate-severe obstructive sleep apnea (OSA) in Iceland identified three clinical clusters based on symptoms and comorbidities. We sought to verify this finding a new cohort examine the generalizability OSA an international ethnically diverse cohort.Using data 972 (apnea-hypopnea index [AHI] ≥ 15 events per hour) recruited from Sleep Apnea Global Interdisciplinary Consortium (SAGIC), we performed latent class analysis 18 self-reported symptom variables,...
Sleep apnea is a sleep disorder with high prevalence in the adult male population. regarded as an independent risk factor for cardiovascular sequelae such ischemic heart attacks and stroke. The diagnosis of requires polysomnographic studies laboratories expensive equipment attending personnel. can be treated effectively using nasal ventilation therapy (nCPAP). Early recognition selection patients related breathing disorders important task. Although it has been suggested that this done on...
<h3>Background</h3> Hypoglossal nerve stimulation has been demonstrated to relieve upper airway obstruction acutely, but its effect on obstructive sleep apnea is not known. <h3>Objective</h3> To determine the response in electrical of hypoglossal nerve. <h3>Methods</h3> Eight patients with were implanted a device that stimulated unilaterally during inspiration. Sleep and breathing patterns examined at baseline before implantation after 1, 3, 6 months last follow-up. <h3>Results</h3>...
To date, the only standard for classification of sleep-EEG recordings that has found worldwide acceptance are rules published in 1968 by Rechtschaffen and Kales. Even though several attempts have been made to automate process, so far no method proven its validity a study including sufficiently large number controls patients all adult age ranges. The present paper describes development optimization an automatic system is based on one central EEG channel, two EOG channels chin EMG channel. It...
Although mammals of different species have sleep patterns, brief sleep-wake transitions commonly are observed across and appear to occur randomly throughout the sleeping period. The dynamical patterns functions these awakenings from not well understood, they often viewed as disruptions (random or pathologic) process. In this article, we hypothesize that may reflect aspects endogenous control mechanism thus exhibit certain robust species. We analyze recordings mice, rats, cats, humans,...
Breathing at very low lung volumes might be affected by decreased expiratory airflow and air trapping. Our purpose was to detect flow limitation (EFL) and, as a consequence, intrinsic positive end-expiratory pressure (PEEPi) in grossly obese subjects (OS). Eight OS with mean body mass index (BMI) of 44 +/- 5 kg/m2 six age-matched normal-weight control (CS) were studied different positions. Negative (NEP) used determine EFL. In contrast CS, EFL found two eight the upright position seven...
The exact influence of sleep-related breathing disorder (SRBD) on blood pressure control remains unknown. We investigated the different degrees SRBD daytime and its association to documented hypertension by examining 1,190 consecutive patients referred for diagnosis SRBD. protocol includes clinical interview, physical examination, office measurement, cholesterol, gas analysis. Unattended home monitoring nocturnal was performed assessment activity (respiratory disturbance index [RDI]). RDI...
Open clinical trials indicate that low doses of pergolide, a long-acting D1 and D2 dopamine agonist, lead to reduction in the symptoms restless legs syndrome (RLS) with subjective improvement sleep quality.To assess therapeutic efficacy pergolide improving measures well-being patients idiopathic RLS using polysomnography ratings.In randomized, double-blind, placebo-controlled crossover design we enrolled 30 according criteria International Study Group. All were free psychoactive drugs for at...
Summary Interrater variability of sleep stage scorings is a well‐known phenomenon. The SIESTA project offered the opportunity to analyse interrater reliability (IRR) between experienced scorers from eight European laboratories within large sample patients with different (sleep) disorders: depression, general anxiety disorder and without non‐organic insomnia, Parkinson's disease, period limb movements in apnoea. results were based on 196 recordings 98 (73 males: 52.3 ± 12.1 years 25 females:...