A5012820753- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Sleep and related disorders
- Sleep and Wakefulness Research
- Tracheal and airway disorders
- Respiratory Support and Mechanisms
- Cardiovascular and Diving-Related Complications
- Sleep and Work-Related Fatigue
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Dysphagia Assessment and Management
- Cardiovascular Syncope and Autonomic Disorders
- Restless Legs Syndrome Research
- Circadian rhythm and melatonin
- Airway Management and Intubation Techniques
- Workplace Health and Well-being
- Glaucoma and retinal disorders
- Parkinson's Disease Mechanisms and Treatments
- Cystic Fibrosis Research Advances
- Employment and Welfare Studies
- Child Nutrition and Feeding Issues
- Pediatric health and respiratory diseases
- Childhood Cancer Survivors' Quality of Life
- Migration, Aging, and Tourism Studies
- Asthma and respiratory diseases
- Voice and Speech Disorders
Sir Charles Gairdner Hospital
2015-2024
West Australian Sleep Disorders Research Institute
2015-2024
The University of Western Australia
2015-2024
California Center for Sleep Disorders
2024
Queen Elizabeth II Medical Centre
2016-2024
The Ohio State University Wexner Medical Center
2024
Universidad de Magallanes
2024
In-Q-Tel
2022
Royal Perth Hospital
2001-2018
Gosford Hospital
2017
Obstructive sleep apnea is associated with an increased risk of cardiovascular events; whether treatment continuous positive airway pressure (CPAP) prevents major events uncertain.After a 1-week run-in period during which the participants used sham CPAP, we randomly assigned 2717 eligible adults between 45 and 75 years age who had moderate-to-severe obstructive coronary or cerebrovascular disease to receive CPAP plus usual care (CPAP group) alone (usual-care group). The primary composite end...
Patients with the sleep apnea/hypopnea syndrome (SAHS) treated by nasal continuous positive airway pressure (CPAP) need to use CPAP long-term prevent recurrence of symptoms. It is thus important clarify level and factors influencing use. We examined determinants objective in 1, 211 consecutive patients SAHS who were prescribed a trial between 1986 1997. Prospective data available 155 (95.4%), median follow-up 22 mo (interquartile range [IQR], 12 36 mo). Fifty-two (4.5%) refused treatment...
A recent study of patients with moderate-severe obstructive sleep apnea (OSA) in Iceland identified three clinical clusters based on symptoms and comorbidities. We sought to verify this finding a new cohort examine the generalizability OSA an international ethnically diverse cohort.Using data 972 (apnea-hypopnea index [AHI] ≥ 15 events per hour) recruited from Sleep Apnea Global Interdisciplinary Consortium (SAGIC), we performed latent class analysis 18 self-reported symptom variables,...
Obstructive sleep apnea (OSA) is reported to have a metabolic profile predisposing cardiovascular disease. However, previous case-control studies not adequately controlled for confounders.To determine whether OSA associated with increased insulin resistance and related risk factors.We performed matched study (n = 42) examining putative risks among men attending clinic (apnea-hypopnea index [AHI] > 15] compared no (AHI < 5). Participants were age +/- 5 yr, body mass 10%, current smoking...
This study aims to describe the pattern of home mechanical ventilation (HMV) usage in Australia and New Zealand. 34 centres providing HMV region were identified asked complete a questionnaire regarding centre demographics, patient diagnoses, equipment settings, staffing levels methods employed implement follow-up therapy. 28 (82%) responded, data on 2,725 patients. The minimum prevalence was 9.9 patients per 100,000 population 12.0 Variation existed across Australian states (range 4–13...
Many adults with obstructive sleep apnea (OSA) use device treatments inadequately and remain untreated.To determine whether combined palatal tongue surgery to enlarge or stabilize the upper airway is an effective treatment for patients OSA when conventional failed.Multicenter, parallel-group, open-label randomized clinical trial of vs ongoing medical management. Adults symptomatic moderate severe in whom had failed were enrolled between November 2014 October 2017, follow-up until August...
Abstract Sleep disorders in adults are associated with adverse health effects including reduced quality of life and increased mortality. However, there is little information on sleep young adults. A cross-sectional observational study was undertaken 1,227 participating the Western Australian Pregnancy (Raine) Study (2012–2014) to describe prevalence common disorders. In-laboratory polysomnography (PSG) validated survey methods were used, Epworth Sleepiness Scale, Pittsburgh Symptom...
This randomized, double-blind, placebo-controlled, crossover study was conducted to evaluate the safety and efficacy of 2 weeks nightly sublingual cannabinoid extract (ZTL-101) in treating chronic insomnia (symptoms ≥3 months).Co-primary endpoints were medication based on adverse event reporting global symptoms (Insomnia Severity Index [ISI]). Secondary included: self-reported (sleep diary), actigraphy-derived, polysomnography measurements sleep onset latency (SOL), wake after (WASO), total...
We tested the hypothesis that continuous positive airway pressure (CPAP) use and outcomes can be improved by an autotitrating CPAP device in patients with obstructive sleep apnea–hypopnea syndrome (OSAHS) who require higher (10 cm H2O or more). In this multisite randomized single-blind cross-over study, 44 (mean age, 49 ± 10 years) were to 6 weeks at laboratory-determined fixed on CPAP. Average nightly was greater automatic mode (306 versus 271 minutes, p = 0.005); median 95th centile...
There is randomized controlled evidence that patients with sleep apnea–hypopnea syndrome (SAHS) treated continuous positive airway pressure (CPAP) have improved daytime function and quality of life. “Before-and-after” data indicate CPAP improves quality, but there no this. We tested the hypothesis in SAHS. also sought correlations between polysomnographic (PSG) indices benefit from use CPAP. Twenty-two SAHS (median, [interquartile range] index, 40 [25–65] events/h) spent 1 mo receiving...
Study Objectives: Obstructive sleep apnea (OSA) is a global health issue and associated with obesity oropharyngeal crowding.Global data are limited on the effect of ethnicity sex these relationships.We compare associations between apnea-hypopnea index (AHI) risk factors across ethnicities sexes within clinics.Methods: This cross-sectional, multicenter study patients OSA from eight centers representing Sleep Apnea Global Interdisciplinary Consortium (SAGIC).Four distinct ethnic groups were...
Randomized controlled trials (RCTs) have shown no reduction in adverse cardiovascular (CV) events patients randomized to continuous positive airway pressure (CPAP) therapy for obstructive sleep apnea (OSA). This study examined whether populations were representative of OSA attending a clinic.
Study Objectives: There is a paucity of contemporary prevalence estimates for common sleep disorders insomnia, obstructive apnea (OSA), and restless legs syndrome.We aimed to assess the clinically significant in middle-aged community sample.Methods: Parents participants community-based Raine underwent assessments between 2015 2017, including comprehensive questionnaires, anthropometric measures, in-laboratory polysomnography.Clinically were defined as chronic insomnia using Pittsburgh Sleep...
Background-The sleep apnoea/ hypopnoea syndrome (SAHS) causes snoring, apnoeas, and restlessness during which partners frequently complain about.A study was undertaken to determine the impact on of SAHS treatment patient with continuous positive airway pressure (CPAP).Methods-Forty nine patients booked for CPAP completed in house validated questionnaires (Pittsburgh quality index, Short Form 36 self-reported health status) before started treatment.Twenty three couples whom index had no...
Patients with obstructive sleep apnoea–hypopnoea syndrome (OSAHS) have elevated circulating levels of tumour necrosis factor (TNF)-α. The hypothesis in this study was that OSAHS might be associated the TNF-α (−308A) gene polymorphism, which results increased production. This examined patients, their siblings and population controls. A total 206 subjects were recruited. All underwent studies clinical review, subsequently classified as having or not depending on frequency, sex, age symptoms....
To investigate whether low levels of physical activity were associated with an increased occurrence obstructive sleep apnea (OSA), OSA-related symptoms, and cardiometabolic risk.A case-control study design was used. OSA cases patients referred to a clinic for suspected (n = 2,340). Controls comprised participants from the Busselton community 1,931). Exercise occupational derived questionnaire data. Associations modelled using logistic linear regression adjusted confounders.In comparison...
The clinical utility of limited-channel sleep studies (which are increasingly conducted at home) versus laboratory polysomnography (PSG) for diagnosing obstructive apnea (OSA) is unclear.To compare patient outcomes after PSG studies.Multicenter, randomized, noninferiority study. (Australian New Zealand Clinical Trials Registry: ACTRN12611000926932).7 academic centers.Patients (n = 406) aged 25 to 80 years with suspected OSA.Sleep study information disclosed physicians comprised level 1 (L1)...
Young adulthood is a critical life period for health and behaviours. Related measurements collected before after birth, during childhood adolescence can provide life-course analysis of important factors that contribute to behaviour in young adulthood. The Western Australian Pregnancy Cohort (Raine) Study has large number such the fetal, perinatal, infancy, periods plans relate them common issues behaviours adults, including spinal pain, asthma, sleep disorders, physical activity sedentary...
Study Objectives: Craniofacial anatomy is recognized as an important predisposing factor in the pathogenesis of obstructive sleep apnea (OSA).This study used three-dimensional (3D) facial surface analysis linear and geodesic (shortest line between points over a curved surface) distances to determine combination measurements that best predicts presence severity OSA.Methods: 3D face photographs were obtained 100 adults without OSA (apnea-hypopnea index [AHI] < 5 events/h), with mild (AHI 15...
Whether continuous positive airway pressure (CPAP) treatment can improve depression or anxiety symptoms in obstructive sleep apnoea (OSA) patients remains uncertain.
Despite evidence of a relationship among obstructive sleep apnea (OSA), metabolic dysregulation, and diabetes, it is uncertain whether OSA treatment can improve parameters. We sought to determine effects long-term continuous positive airway pressure (CPAP) on glycemic control diabetes risk in patients with cardiovascular disease (CVD) OSA.Blood, medical history, personal data were collected substudy 888 participants the Sleep Apnea cardioVascular Endpoints (SAVE) trial which stable CVD...
Abstract Study Objectives Little is known about the interrelationships between sleep regularity, obstructive apnea (OSA) and important health markers. This study examined whether irregular associated with OSA hypertension, if this modifies association hypertension. Methods Six hundred two adults (age mean(SD) = 56.96(5.51) years, female 60%) from Raine who were not evening or night shift workers assessed for (in-laboratory polysomnography; apnea–hypopnea index ≥ 15 events/hour), hypertension...
The aim of the study was to investigate psychosocial function before and after continuous positive airway pressure (CPAP) therapy, establish determinants consequences objective CPAP use. In a prospective, parallel-group study, changes in scores were compared with conservative management or therapy for sleep apnoea/hypopnoea syndrome (SAHS). Patient/partner couples from top (CPAP treated, n=44) bottom (conservatively n=25) waiting list rated marital satisfaction (evaluation nurturing...