A5029713849- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Cardiovascular and Diving-Related Complications
- Tracheal and airway disorders
- Sleep and Wakefulness Research
- Dysphagia Assessment and Management
- Respiratory Support and Mechanisms
- Ultrasound in Clinical Applications
- Lung Cancer Diagnosis and Treatment
- Voice and Speech Disorders
- Venous Thromboembolism Diagnosis and Management
- Pain Management and Opioid Use
- Influenza Virus Research Studies
- Cardiovascular Disease and Adiposity
- Respiratory viral infections research
- Meta-analysis and systematic reviews
- Medical Imaging and Pathology Studies
- Pharmacological Effects and Toxicity Studies
- Asthma and respiratory diseases
- Psychedelics and Drug Studies
- High Altitude and Hypoxia
- Pneumonia and Respiratory Infections
- Sleep and related disorders
- Sepsis Diagnosis and Treatment
- Respiratory and Cough-Related Research
Sir Charles Gairdner Hospital
2010-2024
California Center for Sleep Disorders
2024
West Australian Sleep Disorders Research Institute
2011-2023
The University of Western Australia
2022
Randomized controlled trials (RCTs) have shown no reduction in adverse cardiovascular (CV) events patients randomized to continuous positive airway pressure (CPAP) therapy for obstructive sleep apnea (OSA). This study examined whether populations were representative of OSA attending a clinic.
To investigate the relationship between oxygen desaturation index (ODI), body mass (BMI), and apnea-hypopnea (AHI) in a large sleep clinic population.Retrospective observational.Sleep disorders clinic.11,448 individuals undergoing diagnostic polysomnography (PSG) at clinic.Polysomnography were scored using Chicago criteria. ODI 2%, 3%, 4% threshold levels derived. The study population was subdivided into BMI categories steps of 5 kg/m(2). Mean accuracy for detecting an AHI ≥ 15...
Background From the first case reports of pandemic influenza (H1N1) 2009 it was clear that a significant proportion infected individuals suffered primary viral pneumonia. The objective this study twofold; to assess utility CURB-65 community acquired pneumonia (CAP) severity index in predicting and ICU admission, relative sensitivity nasopharyngeal versus lower respiratory tract sampling for detection CAP. Methods A retrospective cohort 70 patients hospitalised an adult tertiary referral...
Abstract Single‐photon emission computed tomography ( SPECT ) ventilation perfusion V/Q scanning with low‐dose LDCT is an emerging imaging technique for investigation of suspected pulmonary embolism PE ). We aimed to estimate diagnostic utility the combined using results from all patients referred in 2009 compared final diagnosis and 6‐month follow‐up status. was diagnosed 28 106 (26%), including 2 80 (2%) negative . The estimated predictive value 97%. abnormal 43 (41%) patients, 41 who had...
Abstract Study Objectives We tested a telemedicine model of care to initiate continuous positive airway pressure (CPAP) for patients with obstructive sleep apnea (OSA) living in remote Western Australia. Methods A prospective study comparing CPAP initiation population versus standard face-to-face metropolitan population. The primary outcome was average nightly use the final week trial. Results total 186 participants were allocated either (n = 56) or 130). distance from center group 979 km...
Obstructive sleep apnea (OSA) is a highly prevalent condition in people living with schizophrenia or other psychotic disorder. Its treatment continuous positive airway pressure therapy (CPAP) can dramatically improve daytime and physical health function. People disorder, however, are rarely diagnosed treated there no large-scale studies showing evidence of successful CPAP. Using retrospective case-control study approach (N = 554), we examined adherence to effectiveness CPAP trial individuals...
We aimed to analyze long-term trends in characteristics of patients undergoing diagnostic polysomnography (PSG) and subsequently diagnosed with obstructive sleep apnea (OSA) inform delivery services.We studied 24,510 consecutive PSG at a tertiary-care service between 1989 2013. OSA was defined by an hypopnea index (AHI)≥ 5 events/hour. Changes definition flow sensing techniques 2002 created two distinct AHI scoring periods: American Sleep Disorders Association (ASDA) - July Academy Medicine...
To investigate differences between semi-recumbent and supine postures in terms of cough rate, oxygen desaturation, sedative use, patient comfort during the initial phase bronchoscopy. Consecutive bronchoscopy patients (n = 69) participated this observational cohort study. Posture was determined by bronchoscopist's usual practice. Patient demographics, spirometry, pulse, SpO2 were recorded. The defined as time from insertion to visualisation both distal main bronchi. Cough peak nadir SpO2,...
The hypoxic inhalation test (HIT) accurately predicts air travel hypoxaemia, but availability is limited. We assessed whether oxygen saturation (SpO2) during HIT can be predicted by simple measures of lung function and exercise-induced hypoxaemia.Analysis all patients who had testing performed between January 2005 April 2010. Prior to HIT, SpO(2) on room was measured at rest after 2 min moderate exercise. conducted using fractional inspired concentration 0.14 equilibration ≥ 5 min....
Multiple endobronchial polyps are a rare finding. We describe case of multiple benign in 60-year-old woman who presented with chronic cough and occasional hemoptysis. Chest computed tomography revealed bilateral basal cylindrical bronchiectasis, filling defects both main bronchi. Bronchoscopy the presence distal trachea, bronchi, lobar segmental bronchi all lobes lungs, lesions from 2 to 10 mm diameter. Larger were treated argon plasma coagulation. Histopathology was consistent...
Abstract Background In view of the current uncertainty about relationship between obstructive sleep apnoea (OSA) and development major adverse cardiovascular events (MACE) we studied long-term effect continuous positive airway pressure (CPAP) on important subclinical markers known to be causal pathway coronary artery disease (CAD) Methods We used our database clinic patients (n=4,226) who had baseline phenotypic assessments, 2006 2010, including level 1 polysomnography determine presence...
Abstract Introduction Oral Appliance Therapy (OAT) is an effective second line treatment for OSA. However, OAT devices do not have active efficacy monitoring, hence little known about methods to best identify the optimal degree of mandibular advancement. Methods Consecutive OSA patients undergoing at a sleep disorders service were recruited participate in novel titration protocol using nightly monitoring via portable device (NightOwl®, Ectosense, Belgium). Demographic & study (PSG) data,...
Genetic and epidemiologic investigations into obstructive sleep apnoea (OSA) have been limited by a scarcity of sizeable well-characterised clinic cohorts with laboratory-based polysomnography (PSG). This profile reports the characteristics prospective cohort study exploring genotypic phenotypic features OSA ongoing patient follow-up to assess long-term health outcomes. The Western Australian Sleep Health Study (WASHS) recruited patients at large tertiary hospital in Perth, Australia....
Abstract Introduction Randomized controlled trials (RCTs) have shown no reduction in adverse cardiovascular (CV) events patients randomized to continuous positive airway pressure (CPAP) therapy for obstructive sleep apnea (OSA). This study examined whether populations were representative of OSA attending a clinic. Methods Sleep clinic 3,965 consecutive adults diagnosed with by in-laboratory polysomnography from 2006–2010 at tertiary hospital Characteristics these compared participants 5...