A5046990649- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Cardiovascular and Diving-Related Complications
- Sleep and Wakefulness Research
- Sleep and related disorders
- Respiratory Support and Mechanisms
- Tracheal and airway disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular Disease and Adiposity
- Asthma and respiratory diseases
- Circadian rhythm and melatonin
- Sleep and Work-Related Fatigue
- Extracellular vesicles in disease
- Fatty Acid Research and Health
- Chronic Disease Management Strategies
- Long-Term Effects of COVID-19
- Mobile Health and mHealth Applications
- Adipose Tissue and Metabolism
- Cardiovascular Health and Disease Prevention
- MicroRNA in disease regulation
- Dysphagia Assessment and Management
- Regulation of Appetite and Obesity
- Heart Rate Variability and Autonomic Control
- High Altitude and Hypoxia
Hospital Universitari Arnau de Vilanova
2016-2025
Biomedical Research Institute of Lleida
2016-2025
Instituto de Salud Carlos III
2015-2025
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2016-2025
Association Française de Lutte Anti-Rhumastismale
2025
Centre for Biomedical Network Research on Rare Diseases
2013-2025
Hospital Universitari de Santa Maria
2013-2024
Comunidad de Madrid
2021-2024
Universitat de Lleida
2014-2023
Hospital Arnau de Vilanova
2014-2023
Obstructive sleep apnea is associated with an increased risk of cardiovascular events; whether treatment continuous positive airway pressure (CPAP) prevents major events uncertain.After a 1-week run-in period during which the participants used sham CPAP, we randomly assigned 2717 eligible adults between 45 and 75 years age who had moderate-to-severe obstructive coronary or cerebrovascular disease to receive CPAP plus usual care (CPAP group) alone (usual-care group). The primary composite end...
Continuous positive airway pressure (CPAP) is the first-line treatment for patients with symptomatic obstructive sleep apnea (OSA). However, its indication all sleep-disordered breathing, regardless of daytime symptoms, unclear.To evaluate effect CPAP on incidence hypertension or cardiovascular events in a cohort nonsleepy OSA.Multicenter, parallel-group, randomized controlled trial 14 teaching hospitals Spain. Between May 2004 and 2006, 725 consecutive were enrolled who had an...
<h3>Context</h3>Systemic hypertension is prevalent among patients with obstructive sleep apnea (OSA). Short-term studies indicate that continuous positive airway pressure (CPAP) therapy reduces blood in and OSA.<h3>Objective</h3>To determine whether CPAP associated a lower risk of incident hypertension.<h3>Design, Setting, Participants</h3>A prospective cohort study 1889 participants without who were referred to center Zaragoza, Spain, for nocturnal polysomnography between January 1, 1994,...
for the Spanish
Background: The sleep apnea–hypopnea syndrome is defined by a pathologic number of respiratory events during (the index, as the apnea and hypopnea episodes per hour) daytime symptoms (mostly, excessive sleepiness). In patients with syndrome, treatment continuous positive airway pressure (CPAP) normalizes both index diurnal symptoms. However, effect CPAP in persons without sleepiness unclear. Objective: To investigate short-term effects on quality life, objective sleepiness, cognitive...
Rationale: Continuous positive airway pressure (CPAP) is the current treatment for patients with symptomatic obstructive sleep apnea (OSA). Its use all subjects sleep-disordered breathing, regardless of daytime symptoms, unclear.Objectives: This multicenter controlled trial assesses effects 1 year CPAP on blood (BP) in nonsymptomatic, hypertensive OSA.Methods: We evaluated 359 OSA. Inclusion criteria consisted an apnea–hypopnea index (AHI) greater than 19 hour−1, Epworth Sleepiness Scale...
Barbé, Ferran*†; Durán-Cantolla, Joaquín†‡; Sánchez de la Torre, Manuel*†; Martínez-Alonso, Montserrat*; Carmona, Carmen§; Barceló, Antonia†∥; Chiner, Eusebi¶; Masa, Juan F.#†; Gonzalez, Mónica**†††; Marín, Jose M.†††; Garcia-Rio, Francisco‡‡; Atauri, Josefa Diaz**; Terán, Joaquín†§§; Mayos, Mercedes†∥∥; Peña, Mónica†¶; Monasterio, Carmen†¶¶; del Campo, Felix##; Montserrat, Josep M.†*** for the Spanish Sleep and Breathing Network Author Information
Obstructive sleep apnea (OSA) has been associated with increased cancer mortality, but whether it is also incidence unknown.To investigate OSA in a large clinical cohort.A multicenter, cohort study including consecutive patients investigated for suspected between 2003 and 2007 seven Spanish teaching hospitals. Apnea-hypopnea index (AHI) percent nighttime oxygen saturation less than 90% (TSat(90)) were used as surrogates of severity, both continuous variables categorized by tertiles. Cox...
To assess the effect of continuous positive airway pressure (CPAP) on 24 hour ambulatory blood monitoring values in a large number patients with untreated systemic hypertension new onset and obstructive sleep apnoea.Multicentre, double blind, randomised, placebo controlled trial.Eleven general hospitals Spain between 2004 2007.340 recently diagnosed as having by practitioner (systolic ≥140 mm Hg, diastolic ≥90 or both) an apnoea-hypopnoea index per >15 events/hour.Patients were assigned to...
El objetivo principal de este documento internacional consenso sobre apnea obstructiva del sueño es proporcionar unas directrices que permitan a los profesionales sanitarios tomar las mejores decisiones en la asistencia pacientes adultos con esta enfermedad según un resumen crítico literatura más actualizada. grupo trabajo expertos se ha constituido principalmente por 17 sociedades científicas y 56 especialistas amplia representación geográfica (con participación 4 internacionales), además...
It is currently unclear which patients with obstructive sleep apnea (OSA) are at increased cardiovascular risk.
To investigate the association between sleep apnea syndrome (SAS) and automobile accidents, to evaluate potential underlying mechanisms, we prospectively recruited 60 consecutive patients with SAS (apnea-hypopnea index, 58 +/- 3 h-1) healthy control subjects, matched for sex age. The number of accidents during past yr was obtained from participants insurance companies. We quantified degree daytime sleepiness (Epworth scale), anxiety depression (Beck tests), assessed level vigilance (PVT 192)...
Standard practice for continuous positive airway pressure (CPAP) treatment in sleep apnea and hypopnea syndrome (SAHS) requires titration during attended laboratory polysomnography. However, polysomnographic is expensive time-consuming. The aim of this study was to ascertain, a large sample CPAP-naive patients, whether CPAP performed by an unattended domiciliary autoadjusted device or with predicted formula as effective full main outcomes were the apnea-hypopnea index subjective daytime...
The aim of this trial was to evaluate the effectiveness continuous positive airway pressure (CPAP) in patients with mild sleep apnea- hypopnea syndrome (SAHS). One hundred forty-two consecutive SAHS (apnea-hypopnea index 10-30, without severe sleepiness) were randomly assigned receive conservative treatment (CT)-sleep hygiene and weight loss-(65 patients) or CT plus CPAP (77 patients), 125 (86% males, age: 54 +/- 9 yr, BMI: 29 4 kg/m(2), AHI: 20 6, ESS: 12 4) completed follow-up. following...
This investigation evaluates, in a prospective, randomized and controlled manner, whether noninvasive ventilatory support (NIVS) with bilevel positive airway pressure (BiPAP) facilitates recovery from acute respiratory failure (ARF) patients chronic obstructive pulmonary disease (COPD). Twenty four (mean age (+/-SEM) 68 +/- 2 yrs) COPD (forced expiratory volume one second (FEV1) at discharge 33 2% predicted), who attended the emergency room because of ARF (pH 7.33 0.01; arterial oxygen...
The prevalence of cardiovascular diseases is increased in patients with the obstructive sleep apnoea syndrome (OSAS). fall and rise arterial oxygenation that follows each may increase lipid peroxidation contributes to explaining this association. In present study, authors determined OSAS effect treatment continuous positive airway pressure (CPAP). Fourteen male severe (59+/-5 x h(-1)) (+/-SEM) 13 healthy nonsmoking, volunteers similar age were studied. Patients studied at diagnosis after...
The episodes of hypoxia/re-oxygenation associated with the respiratory disturbances observed in patients obstructive sleep apnoea syndrome (OSAS) may induce generation oxygen free radicals. Indeed, several studies suggest that OSAS is oxidative stress. present study tested hypothesis have an alteration antioxidant defences. plasma levels total status (TAS), glutathione peroxidase (GPX), gamma-glutamyltransferase (GGT), vitamins A, E, B12 and folate, homocysteine were determined 47 37 healthy...