A5075135513- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Sleep and related disorders
- Respiratory Support and Mechanisms
- Cardiovascular and Diving-Related Complications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Restless Legs Syndrome Research
- Health and Lifestyle Studies
- Parkinson's Disease Mechanisms and Treatments
- Cardiovascular Syncope and Autonomic Disorders
- Circadian rhythm and melatonin
- Tracheal and airway disorders
- Spinal Dysraphism and Malformations
- Breastfeeding Practices and Influences
- Nursing care and research
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Airway Management and Intubation Techniques
- Neonatal Respiratory Health Research
- Cerebrospinal fluid and hydrocephalus
- Obsessive-Compulsive Spectrum Disorders
- Neurogenetic and Muscular Disorders Research
- Pulmonary Hypertension Research and Treatments
- Personality Disorders and Psychopathology
University of Illinois Urbana-Champaign
2025
Hospital Universitario Virgen del Rocío
2013-2024
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2015-2024
Instituto de Biomedicina de Sevilla
2019-2024
Universidad de Sevilla
2019-2024
Universidad El Bosque
2024
Instituto de Salud Carlos III
2010-2023
Vall d'Hebron Hospital Universitari
2012-2023
Universitat Autònoma de Barcelona
2006-2022
Centro de Investigación Biomédica en Red
2012-2022
Objectives This controlled trial assessed the effect of continuous positive airway pressure (CPAP) on blood (BP) in patients with obstructive sleep apnea (OSA) and resistant hypertension (RH). Methods We evaluated 96 hypertension, defined as clinic BP at least 140/90 mmHg despite treatment three drugs adequate doses, including a diuretic. Patients underwent polysomnography 24-h ambulatory monitoring (ABPM). They were classified consulting room or ABPM-confirmed according to lower higher than...
Rationale Despite a significant association between obesity hypoventilation syndrome (OHS) and cardiac dysfunction, no randomised trials have assessed the impact of non-invasive ventilation (NIV) or CPAP on structure function by echocardiography. Objectives We performed secondary analysis data from largest multicentre controlled trial OHS (Pickwick project, n=221) to determine comparative efficacy 2 months NIV (n=71), (n=80) lifestyle modification (control group, n=70) structural functional...
Obstructive sleep apnea syndrome (OSAS) is a process that associated with the development of arterial hypertension, main risk factor for aortic dissection and during obstructive episodes upper airways marked increases in transmural pressure aorta wall. The aim this work was to study association between OSAS. Nineteen consecutive patients thoracic 19 hypertensive similar age, sex, body mass index were studied by clinical questionnaire polysomnography. Snoring nonrefreshing common both groups....
The high prevalence of obstructive sleep apnea in patients with resistant hypertension could be mediated by an activation the renin-angiotensin-aldosterone system. This study assessed impact continuous positive airway pressure (CPAP) treatment on plasma aldosterone concentration (PAC).One hundred and twenty-four were assessed, those who fulfilled inclusion criteria (n = 116) underwent full night polysomnography, 24-h ambulatory blood monitoring, PAC measurement. Patients apnea-hypopnea index...
Rationale: Obesity hypoventilation syndrome (OHS) has been associated with cardiac dysfunction. However, randomized trials assessing the impact of long-term noninvasive ventilation (NIV) or continuous positive airway pressure (CPAP) on structure and function assessed by echocardiography are lacking.Objectives: In a prespecified secondary analysis largest multicenter controlled trial OHS (Pickwick Project; N = 221 patients coexistent severe obstructive sleep apnea), we compared effectiveness...
Noninvasive ventilation (NIV) is an effective form of treatment in obesity hypoventilation syndrome (OHS) with severe OSA. However, there paucity evidence patients OHS without OSA phenotype.Is NIV phenotype?In this multicenter, open-label parallel group clinical trial performed at 16 sites Spain, we randomly assigned 98 stable ambulatory untreated and apnea-hypopnea index < 30 events/h (ie, no OSA) to or lifestyle modification (control group) using simple randomization through electronic...
Abstract Growing up is rarely easy, yet adolescents and young adults today are reporting distress at rates never seen before. We propose this trend can be traced to societal forces that accelerate suppress development, resulting in developmental anxiety (i.e., worry about meeting adult milestones on time, if ever). Drawing foundational theories from family sciences, we introduce hurries waits as umbrella terms for these simultaneous contradictory explain how may arise the tension they place...
Obstructive sleep apnoea (OSA) is common in patients with resistant hypertension, but understanding of the pathogenic mechanisms linking both conditions limited. This study assessed prevalence OSA and relationships between 24-h blood pressure (BP) 62 consecutive defined as clinic BP values ≥ 140/90 despite prescription at least three drugs adequate doses, including a diuretic. In order to exclude 'white coat effect', only ambulatory 125/80 were recruited. Patients underwent polysomnography,...
The aim of the present study is to describe prevalence sleep disorders in a large group patients with Chiari malformation type 1 (CM-1) and determine presence risk factors associated these abnormalities.Prospective consecutive patient selection. We included 90 adult CM-1, defined by cerebellar tonsillar descent (TD) ≥3 mm. Clinical, neuroradiological studies, nocturnal polysomnography (PSG) was carried out. In addition, were also subclassified into 2 CM subtypes: obex above foramen magnum...
Non-restorative sleep is a hallmark symptom of chronic fatigue syndrome/myalgic encephalomyelitis. However, little known about self-reported disturbances in these subjects. This study aimed to assess the quality and its impact on life Spanish community-based encephalomyelitis cohort. A prospective cross-sectional cohort was conducted 1,455 patients. Sleep quality, fatigue, pain, functional capacity impairment, psychopathological status, anxiety/depression health-related were assessed using...
Abstract Introduction Levodopa‐carbidopa intestinal gel ( LCIG ) infusion has demonstrated to improve motor fluctuations. The aim of this study is assess the long‐term safety and effectiveness in advanced Parkinson's disease PD patients with fluctuations its effect nonmotor symptoms. Methods Adverse events AE their management, clinical motor, aspects were assessed up 10 years. Thirty‐seven treated LGIC ; three subsets patients, specific batteries tests used cognitive behavior assessment for...
Type 2 diabetes mellitus (T2DM) and obesity have become two of the main threats to public health in Western world. In addition, is most important determinant sleep apnea-hypopnea syndrome (SAHS), a condition that adversely affects glucose metabolism. However, it unknown whether patients with more severe SAHS than non-diabetic subjects. The aim this cross-sectional case-control study was evaluate obese T2DM are prone
Summary Obstructive sleep apnea syndrome is very prevalent in hypertensive subjects. Moreover, obstructive activates multiple processes that might be associated with silent cerebral infarct independently of established risk factors. Our aim to estimate the frequency patients and without infarct, determine whether an independent factor and/or lacunar hypertension. In this matched cross‐sectional study performed subjects, each patient detected by magnetic resonance imaging was two infarct....
Type 2 diabetes (T2D) is an independent risk factor for sleep breathing disorders. However, it unknown whether T2D affects daily somnolence and quality of independently the impairment polysomnographic parameters.A case-control study including 413 patients with non-diabetic subjects, matched by age, gender, BMI, waist neck circumferences. A polysomnography was performed daytime sleepiness evaluated using Epworth Sleepiness Scale (ESS). In addition, 135 subjects 45 controls same previous...
La Sociedad Espanola de Sueno tiene como uno sus principales objetivos la promocion un sueno saludable en poblacion general y profesionales salud. El presente documento pretende realizar una revision literatura cientifica actual sobre habitos que sirva fundamento para establecer unas recomendaciones generales utiles espanola, el contexto saludable, e identificar aquellos retos investigacion sueno. desarrollo del se ha realizado por equipo multidisciplinar miembros integrado expertos medicina...
Although sleep apnea-hypopnea syndrome (SAHS) is highly prevalent in patients with type 2 diabetes (T2D), it unknown whether or not subjects and without T2D share the same breathing pattern.A cross-sectional study SAHS according to presence (n = 132) 264) of T2D. Both groups were matched by age, gender, BMI, waist neck circumferences. A subgroup 125 was also AHI. The exclusion criteria included chronic respiratory disease, alcohol abuse, use sedatives, heart failure. higher apnea hypopnea...