A5103261928- Fibromyalgia and Chronic Fatigue Syndrome Research
- Musculoskeletal pain and rehabilitation
- Pleural and Pulmonary Diseases
- Health, psychology, and well-being
- Long-Term Effects of COVID-19
- Ultrasound in Clinical Applications
- Pneumothorax, Barotrauma, Emphysema
- Streptococcal Infections and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Exercise and Physiological Responses
- Eating Disorders and Behaviors
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Myofascial pain diagnosis and treatment
- Psychosomatic Disorders and Their Treatments
- Drug-Induced Hepatotoxicity and Protection
- Coenzyme Q10 studies and effects
- Lung Cancer Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- Infectious Diseases and Tuberculosis
- Hematological disorders and diagnostics
- Infective Endocarditis Diagnosis and Management
- Infectious Disease Case Reports and Treatments
- IgG4-Related and Inflammatory Diseases
- Lung Cancer Research Studies
- Liver Disease Diagnosis and Treatment
Universitat Autònoma de Barcelona
2014-2024
Vall d'Hebron Institut de Recerca
2013-2024
Vall d'Hebron Hospital Universitari
2012-2024
Hospital Universitario San Rafael
2021
Consorci Sanitari de Terrassa
2015
Hospital Virgen del Valle
2010
Hebron University
2009
Delfos Hospital
2004-2008
Universitat de Barcelona
2004
Hospital General de Catalunya
2002
Abstract Background Heart rate variability (HRV) is an objective, non-invasive tool to assessing autonomic dysfunction in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). People with CFS/ME tend have lower HRV; however, the literature there are only a few previous studies (most of them inconclusive) on their association illness-related complaints. To address this issue, we assessed value different diurnal HRV parameters as potential biomarker and also investigated relationship...
Abstract Background Chronic Fatigue Syndrome (CFS) is a debilitating neuro-immune disorder of unknown etiology diagnosed by an array clinical manifestations. Although several immunological abnormalities have been described in CFS, their heterogeneity has limited diagnostic applicability. Methods Immunological features CFS were screened 22 individuals fulfilling Fukuda criteria and 30 control healthy individuals. Peripheral blood T, B NK cell function phenotype analyzed flow cytometry both...
Chronic fatigue syndrome (CFS) and fibromyalgia (FM) are complex serious illnesses that affect approximately 2.5% 5% of the general population worldwide, respectively. The etiology is unknown; however, recent studies suggest mitochondrial dysfunction has been involved in pathophysiology both conditions. We have investigated possible association between biogenesis oxidative stress patients with CFS FM. studied 23 patients, 20 FM 15 healthy controls. Peripheral blood mononuclear cell showed...
Chronic fatigue syndrome (CFS) is a chronic and extremely debilitating illness characterized by prolonged multiple symptoms with unknown cause, diagnostic test, or universally effective treatment. Inflammation, oxidative stress, mitochondrial dysfunction, CoQ10 deficiency have been well documented in CFS. We conducted an 8-week, randomized, double-blind placebo-controlled trial to evaluate the benefits of oral (200 mg/day) plus NADH (20 supplementation on biochemical parameters 73 Spanish...
Accumulating evidence suggests that autonomic dysfunction and persistent systemic inflammation are common clinical features in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) long COVID. However, there is limited knowledge regarding their potential association with circulating biomarkers illness severity these conditions.
Fibromyalgia (FM) is a highly disabling syndrome defined by low pain threshold and permanent state of pain. The mechanisms explaining this complex disorder remain unclear, its genetic factors have not yet been identified. With the aim elucidating FM susceptibility factors, we selected 313 cases having comorbidities, genotyped them on Illumina 1 million duo array. Genotypic data from 220 control women (Illumina 610k array) was obtained for genome-wide association scan (GWAS) analysis. Copy...
To compare the accuracy of working length (WL) determination using Raypex 6(®) electronic apex locator and cone-beam computed tomography (CBCT).A total 150 extracted human teeth were decoronated randomly assigned to five groups (n = 30). WL was measured with at both 'constriction' 'apex' marks under dry conditions (group 1) or 2.5% NaOCl, distilled water Ultracain(®) (groups 2-4). The radiological 5) calculated from bucco-lingual mesio-distal CBCT sections. Differences between electronic,...
SummaryBackground & aimsChronic Fatigue Syndrome (CFS) is a complex condition, characterized by severe disabling fatigue with no known cause, established diagnostic tests, and universally effective treatment. Several studies have proposed symptomatic treatment coenzyme Q10 (CoQ10) nicotinamide adenine dinucleotide (NADH) supplementation. The primary endpoint was to assess the effect of CoQ10 plus NADH supplementation on age-predicted maximum heart rate (max HR) during cycle ergometer test....
Introduction Fibromyalgia (FM) is mainly characterized by widespread pain and multiple accompanying symptoms, which hinder FM assessment management. In order to reduce heterogeneity we classified clinical data into simplified dimensions that were used define subgroups. Material Methods 48 variables evaluated in 1,446 Spanish cases fulfilling 1990 ACR criteria. A partitioning analysis was performed find groups of similar each other. Similarities between identified the grouped dimensions. This...
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex, multisystem, and profoundly debilitating neuroimmune disease, probably of post-viral multifactorial etiology. Unfortunately, no accurate diagnostic or laboratory tests have been established, nor are any universally effective approved drugs currently available for its treatment. This study aimed to examine whether oral coenzyme Q10 NADH (reduced form nicotinamide adenine dinucleotide) co-supplementation could improve...
The response of the fibrinolytic system to inflammatory mediators in empyema and complicated parapneumonic pleural effusions is still uncertain. We prospectively analysed 100 patients with effusion: 25 or effusion, 22 tuberculous 28 malignant effusion transudate effusion. Inflammatory mediators, tumour necrosis factor-α (TNF-α), interleukin-8 (IL-8) polymorphonuclear elastase, were measured serum fluid. Fibrinolytic parameters, plasminogen, tissue-type plasminogen activator (t-PA) urokinase...
Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) patients frequently show autonomic symptoms which may be associated with a hypothalamic dysfunction. This study aimed to explore circadian rhythm patterns in rest and activity distal skin temperature (DST) their association self-reported outcome measures, CFS/ME healthy controls at two different times of year. Ten women who met both the 1994 CDC/Fukuda definition 2003 Canadian criteria for were included study, along ten matched age,...
Few reports have examined the association between unemployment and work disability in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). This study explored key determinants of a CFS/ME cohort.
There is growing evidence of the significance gastrointestinal complaints in impairment intestinal mucosal barrier function and inflammation fibromyalgia (FM) myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). However, data on permeability gut dysfunction FM ME/CFS are still limited with conflicting results. This study aimed to assess circulating biomarkers potentially related bacterial translocation their association self-reported symptoms these conditions.A pilot multicenter,...
Non-restorative sleep is a hallmark symptom of chronic fatigue syndrome/myalgic encephalomyelitis. However, little known about self-reported disturbances in these subjects. This study aimed to assess the quality and its impact on life Spanish community-based encephalomyelitis cohort. A prospective cross-sectional cohort was conducted 1,455 patients. Sleep quality, fatigue, pain, functional capacity impairment, psychopathological status, anxiety/depression health-related were assessed using...
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a neuroinflammatory, multifaceted chronic disorder of unknown cause. Accumulating data indicate link between redox imbalance, mitochondrial dysfunction, and inflammation status in ME/CFS. Coenzyme Q10 (CoQ10) selenium as effective antioxidant anti-inflammatory agents have shown potential clinical implications diseases; however, their therapeutic benefits ME/CFS remain elusive. This open-label exploratory study aimed to evaluate...