María Cleofé Zaragozá

ORCID: 0000-0002-9797-0219
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About
Contact & Profiles
Research Areas
  • Fibromyalgia and Chronic Fatigue Syndrome Research
  • Long-Term Effects of COVID-19
  • Olfactory and Sensory Function Studies
  • Musculoskeletal pain and rehabilitation
  • Exercise and Physiological Responses
  • Fatty Acid Research and Health
  • Heart Rate Variability and Autonomic Control
  • Health, psychology, and well-being
  • Sleep and related disorders
  • Spaceflight effects on biology
  • Eating Disorders and Behaviors
  • Seaweed-derived Bioactive Compounds
  • Moringa oleifera research and applications
  • Thermoregulation and physiological responses
  • Nitric Oxide and Endothelin Effects
  • Eicosanoids and Hypertension Pharmacology
  • Microbial Metabolites in Food Biotechnology
  • Impact of Technology on Adolescents
  • Adipose Tissue and Metabolism
  • Workplace Health and Well-being
  • Folate and B Vitamins Research
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • T-cell and Retrovirus Studies
  • Child Nutrition and Feeding Issues
  • IL-33, ST2, and ILC Pathways

Vall d'Hebron Institut de Recerca
2018-2023

Universitat Autònoma de Barcelona
2018-2019

Universitat de Barcelona
1995-2011

Centre d’Étude et de Valorisation des Algues
2008

University of Milan
2008

Abstract Background Heart rate variability (HRV) is an objective, non-invasive tool to assessing autonomic dysfunction in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). People with CFS/ME tend have lower HRV; however, the literature there are only a few previous studies (most of them inconclusive) on their association illness-related complaints. To address this issue, we assessed value different diurnal HRV parameters as potential biomarker and also investigated relationship...

10.1186/s12967-019-02184-z article EN cc-by Journal of Translational Medicine 2020-01-06

The consumption of seaweeds has increased in recent years. However, their adverse and beneficial effects have scarcely been studied. Two extracts from the brown seaweed Fucus vesiculosus containing 28.8% polyphenols or 18% plus 0.0012% fucoxanthin obtained studied to determine toxicity mice rats also antioxidant activity. Both were shown lack any relevant toxic an acute test following a 4 week daily treatment rats. exhibited activity noncellular systems activated RAW 264.7 macrophages, as...

10.1021/jf8007053 article EN Journal of Agricultural and Food Chemistry 2008-08-07

Accumulating evidence suggests that autonomic dysfunction and persistent systemic inflammation are common clinical features in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) long COVID. However, there is limited knowledge regarding their potential association with circulating biomarkers illness severity these conditions.

10.1186/s12967-024-05148-0 article EN cc-by Journal of Translational Medicine 2024-04-10

Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) patients frequently show autonomic symptoms which may be associated with a hypothalamic dysfunction. This study aimed to explore circadian rhythm patterns in rest and activity distal skin temperature (DST) their association self-reported outcome measures, CFS/ME healthy controls at two different times of year. Ten women who met both the 1994 CDC/Fukuda definition 2003 Canadian criteria for were included study, along ten matched age,...

10.1371/journal.pone.0198106 article EN cc-by PLoS ONE 2018-06-06

Few reports have examined the association between unemployment and work disability in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). This study explored key determinants of a CFS/ME cohort.

10.1186/s12889-019-7225-z article EN cc-by BMC Public Health 2019-06-28

There is accumulating evidence of autonomic dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); however, little known about its association with circadian rhythms and endothelial dysfunction. This study aimed to explore the responses through an orthostatic test analysis peripheral skin temperature variations vascular endothelium state ME/CFS patients. Sixty-seven adult female patients 48 healthy controls were enrolled. Demographic clinical characteristics assessed...

10.3390/ijms24054835 article EN International Journal of Molecular Sciences 2023-03-02

Oxidative stress contributes to lipid peroxidation and decreases nitric oxide (NO) bioavailability in atherosclerosis. While long-chain (n-3) polyunsaturated fatty acids (PUFA) are easily oxidized vitro, they improve endothelial function. Hence, this study postulates that PUFA decrease atherogenic oxidative vivo. To test this, apoE–/– mice were fed a corn oil- or fish oil (FO)-rich diet for 8, 14 20 weeks parameters related NO superoxide (O2.–) plus markers of protein damage the aortic root...

10.3109/10715762.2010.485992 article EN Free Radical Research 2010-06-09

Non-restorative sleep is a hallmark symptom of chronic fatigue syndrome/myalgic encephalomyelitis. However, little known about self-reported disturbances in these subjects. This study aimed to assess the quality and its impact on life Spanish community-based encephalomyelitis cohort. A prospective cross-sectional cohort was conducted 1,455 patients. Sleep quality, fatigue, pain, functional capacity impairment, psychopathological status, anxiety/depression health-related were assessed using...

10.1111/jsr.12703 article EN Journal of Sleep Research 2018-05-16

ABSTRACT Chronic Fatigue Syndrome (CFS), also known as Myalgic Encephalomyelitis (ME) is an acquired, complex and multisystem condition of unknown etiology, no established diagnostic lab tests universally FDA‐approved drugs for treatment. CFS/ME characterised by unexplicable disabling fatigue often associated with numerous core symptoms. A growing body evidence suggests that extracellular vesicles (EVs) play a role in cell‐to‐cell communication, are involved both physiological pathological...

10.1080/20013078.2018.1453730 article EN cc-by-nc Journal of Extracellular Vesicles 2018-03-22

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex, multisystem, and profoundly debilitating condition, probably of multifactorial etiology. No effective approved drugs are currently available for its treatment. Several studies have proposed symptomatic treatment with melatonin zinc supplementation in chronic illnesses; however, little known about the synergistic effect this on fatigue-related symptoms ME/CFS. The primary endpoint study was to assess oral plus Secondary...

10.3390/antiox10071010 article EN cc-by Antioxidants 2021-06-23

This study aimed to investigate circadian rhythm manifestations in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) patients (including a subpopulation of long-COVID patients) and matched healthy controls while also exploring their association with cardiovascular health variables. Thirty-one ME/CFS (75% females), 23 individuals diagnosed post-COVID (56% females) 31 (68% were enrolled this study. Demographic clinical characteristics assessed using validated self-reported outcome...

10.1080/07420528.2024.2380020 article EN Chronobiology International 2024-07-22

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex, multisystem, and profoundly debilitating condition, probably of multifactorial etiology. No effective approved drugs are currently available for its treatment. Several studies have proposed symptomatic treatment with melatonin zinc supplementation in chronic illnesses; however, little known about the synergistic effect this on fatigue-related symptoms ME/CFS. The primary endpoint study was to assess oral plus Secondary...

10.20944/preprints202103.0234.v1 preprint EN 2021-03-08

Abstract Background Accumulating evidence suggests that autonomic dysfunction and persistent systemic inflammation are common clinical features in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) long COVID. However, there is limited knowledge regarding their potential association with circulating biomarkers illness severity status. Methods This prospective, cross-sectional, case-control cohort study aimed to distinguish between the two patient populations by using self-reported...

10.21203/rs.3.rs-3736031/v1 preprint EN cc-by Research Square (Research Square) 2023-12-16

Abstract Purpose There is accumulating evidence of autonomic dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS); however, little known about its association with circadian rhythms and endothelial dysfunction. This study aimed to explore the relationship between responses using an orthostatic test, skin temperature variations, circulating biomarkers ME/CFS. Methods Sixty-seven adult female ME/CFS patients 48 matched healthy controls were enrolled. Demographic clinical...

10.21203/rs.3.rs-2044838/v1 preprint EN cc-by Research Square (Research Square) 2022-09-21
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