A5007368691- Genomics, phytochemicals, and oxidative stress
- Heme Oxygenase-1 and Carbon Monoxide
- Angiogenesis and VEGF in Cancer
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Nitric Oxide and Endothelin Effects
- Vitamin C and Antioxidants Research
- Antioxidant Activity and Oxidative Stress
- Eicosanoids and Hypertension Pharmacology
- Phytoestrogen effects and research
- Air Quality and Health Impacts
- MicroRNA in disease regulation
- Gestational Diabetes Research and Management
- Glutathione Transferases and Polymorphisms
- Climate Change and Health Impacts
- Genetics, Aging, and Longevity in Model Organisms
- Trace Elements in Health
- Phytochemicals and Antioxidant Activities
- Cancer, Hypoxia, and Metabolism
- Mesenchymal stem cell research
- Cell Adhesion Molecules Research
- Health, Environment, Cognitive Aging
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
King's College London
2016-2025
University of Oxford
2023-2025
British Heart Foundation
2015-2024
Faculty (United Kingdom)
2016-2021
Novo Nordisk (Denmark)
2014-2017
Nephrologisches Zentrum Goettingen
2017
Glostrup Hospital
2017
Rigshospitalet
2017
St Thomas' Hospital
2017
University of Tsukuba
1998-2015
BackgroundSexually active older adults are often more susceptible to HIV and other sexually transmitted infections (STIs) due various health conditions (especially a weakened immune system) low use of condoms. We aimed assess the global, regional, national burdens trends STIs in from 1990 2019.MethodsWe retrieved data Global Burden Diseases, Injuries, Risk Factors Study (GBD) 2019 on incidence disability-adjusted life-years (DALYs) (syphilis, chlamydia, gonorrhoea, trichomoniasis, genital...
In utero exposure to gestational diabetes mellitus (GDM) is associated with an increased risk of type 2 and cardiovascular disease in later life, yet the underlying mechanisms remain be elucidated. We examined effects GDM on proteome, redox status, nuclear factor erythroid 2–related (Nrf2)-mediated antioxidant gene expression human fetal endothelial cells. Proteomic analysis revealed that proteins involved homeostasis were significantly altered mitochondrial superoxide generation, protein...
α-Calcitonin gene-related peptide (αCGRP) is a vasodilator, but there limited knowledge of its long-term cardiovascular protective influence. We hypothesized that αCGRP protects against the onset and development angiotensin II-induced hypertension have identified mechanisms at vascular level. Wild-type knockout mice similar baseline blood pressure were investigated in II model for 14 28 days. exhibited enhanced aortic hypertrophy. gene expression was increased dorsal root ganglia conduit...
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Vascular ageing in conditions such as atherosclerosis, diabetes and chronic kidney disease, is associated with the activation of renin angiotensin system (RAS) diminished expression antioxidant defences mediated by transcription factor nuclear erythroid 2-related 2 (Nrf2). The anti-ageing hormone klotho promotes longevity protects against cardiovascular renal diseases. Klotho has been shown to activate Nrf2 attenuate oxidative damage neuronal cells, however, mechanisms which it vascular...
Research into the therapeutic potential of α-calcitonin gene-related peptide (α-CGRP) has been limited because its nature and short half-life. Here, we evaluate whether a novel potent long-lasting (t½ ≥7 hours) acylated α-CGRP analogue (αAnalogue) could alleviate reverse cardiovascular disease in 2 distinct murine models hypertension heart failure vivo.The ability αAnalogue to act selectively via CGRP pathway was shown skin by using receptor antagonist. The effect on angiotensin II-induced...
We recently reported that soy isoflavones increase gene expression of endothelial nitric-oxide synthase (eNOS) and antioxidant defense enzymes, resulting in improved function lower blood pressure vivo. In this study, we establish equol (1-100 nM) causes acute endothelium- nitric oxide (NO)-dependent relaxation aortic rings rapidly (2 min) activates eNOS human umbilical vein cells. Intracellular Ca2+ cyclic AMP levels were unaffected by treatment (100 nM, 2 with equol, daidzein, or genistein....