A5087118195- Peripheral Artery Disease Management
- Venous Thromboembolism Diagnosis and Management
- Aortic aneurysm repair treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic Disease and Treatment Approaches
- Radiation Dose and Imaging
- Blood Coagulation and Thrombosis Mechanisms
- Angiogenesis and VEGF in Cancer
- Cerebrovascular and Carotid Artery Diseases
- Vascular Procedures and Complications
- Infectious Aortic and Vascular Conditions
- Coronary Interventions and Diagnostics
- Advanced MRI Techniques and Applications
- Advanced X-ray and CT Imaging
- Ion channel regulation and function
- Diagnosis and Treatment of Venous Diseases
- Cardiac Imaging and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Central Venous Catheters and Hemodialysis
- Cancer, Hypoxia, and Metabolism
- Diversity and Career in Medicine
- Tissue Engineering and Regenerative Medicine
- MRI in cancer diagnosis
- Lymphatic System and Diseases
- Pain Management and Treatment
Phoenix Children's Hospital
2023-2025
King's College London
2015-2024
Guy's and St Thomas' NHS Foundation Trust
2013-2024
St Thomas' Hospital
2012-2024
Colorado State University
2024
King's College Hospital
2017-2024
King's College Hospital NHS Foundation Trust
2024
British Heart Foundation
2011-2023
Phoenix College
2023
University of Arizona
2023
2 Dimensional 3 Image Fusion Artificial Intelligence Fluoroscopy As Low Reasonably Achievable Air Kerma Automatic Brightness Control Exposure Anterior Posterior Active Personal Dosimeter Cumulative Cone Beam Computed Tomography Angiography Dose Area Product Digital Imaging and Communications in Medicine Deoxyribonucleic Acid Detective Quantum Efficiency Diagnostic Reference Level Subtraction Effective European Basic Safety Standards Directive Journal of Vascular Endovascular Surgery...
Radiation exposure during fluoroscopically guided interventions such as endovascular aortic repair (EVAR) is a growing concern for operators. This study aimed to measure DNA damage/repair markers in operators perfoming EVAR.Expression of the marker, γ-H2AX and damage response phosphorylated ataxia telangiectasia mutated (pATM), were quantified circulating lymphocytes peri-operative period (infrarenal, branched, fenestrated) open using flow cytometry. These separately measured same but this...
The magnetic resonance longitudinal relaxation time (T1) changes with thrombus age in humans. In this study, we investigate the possible mechanisms that give rise to T1 signal venous thrombi and whether are informative of susceptibility lysis.Venous thrombosis was induced vena cava BALB/C mice, temporal correlated composition. mean shortest at 7 days following induction returned blood as resolved. related methemoglobin formation further processing. Studies inducible nitric oxide synthase...
Objective— Deep venous thrombosis is a major health problem. Thrombolytic therapies are effective in recanalizing the veins and preventing post-thrombotic complications, but there no consensus on selection criteria. The aim of this study was to investigate fibrin-specific MRI contrast agent (EP-2104R) for accurate quantification thrombus’ fibrin content vivo identification thrombus suitable thrombolysis. Approach Results— Venous induced inferior vena cava 8- 10-week-old male BALB/C mice...
Venous thromboembolism is a common complication in patients with cancer, resulting significant morbidity and mortality. Clinical studies suggest that the incidence of venous thromboembolic events increased after treatment these antiangiogenic agents. Thrombi resolve through process remodeling, involving formation microvascular channels within thrombus. Our aim was to determine whether inhibiting angiogenesis affects thrombus resolution.Thrombus induced inferior vena cava mice. These mice...
L-selectin is a cell adhesion molecule that tethers free-flowing leukocytes from the blood to luminal vessel walls, facilitating initial stages of their emigration circulation toward an extravascular inflammatory insult. Following shear-resistant wall, has frequently been reported be rapidly cleaved plasma membrane (known as ectodomain shedding), with little knowledge timing or functional consequence this event. Using advanced imaging techniques, we observe shedding occurring exclusively...
The reactive oxygen species–generating enzyme NADPH oxidase 4 (Nox4) is up-regulated in the heart after myocardial infarction (MI). Mice with cardiomyocyte-targeted Nox4 overexpression (TG) displayed increased macrophages at baseline, skewing toward an M2 phenotype compared wild-type controls (WT). After MI, TG mice had a higher proportion of along survival, decreased cardiac remodeling, and better contractile function than mice. post-MI increase matrix metalloproteinase–2 activity was...
Abstract Genital edema is a rare presentation of Crohn's disease (CD), also known as metastatic CD (MCD). This may precede, co‐occur with, or follow gastrointestinal symptoms and present diagnostic challenge. We aimed to characterize the features, clinical courses, pathogenesis, outcomes patients with MCD increase understanding promote timely management. A retrospective review four diagnosed was conducted at Phoenix Children's Hospital Colorado. Patients presented painful painless...
Despite decades of effort aimed at developing clinically effective cell therapies, including mixed population mononuclear cells, to revascularize the ischemic limb, there remains a paucity patient-based studies that inform function and fate candidate types. In this study, we showed circulating proangiogenic/arteriogenic monocytes (PAMs) expressing FcγIIIA receptor CD16 were elevated in patients with chronic limb-threatening ischemia (CLTI), these amounts decreased after revascularization....
Multifocal renal cell carcinomas (RCCs), together with angiomyolipomas (AMLs) and cysts, were identified in early adult life two sisters tuberous sclerosis (TSC). They members of a multigenerational family showing strong evidence for mutant TSC causing gene on chromosome 9 (TSC1). Previous reports multifocal RCC young patients suggest that constitutional mutations at the loci may predispose to RCC. In rat germline mutation affecting TSC2 is associated transmission as an autosomal dominant...
Use of blood oxygenation level-dependent cardiovascular magnetic resonance (BOLD-CMR) to assess perfusion in the lower limb has been hampered by poor reproducibility and a failure reliably detect post-revascularization improvements patients with critical ischemia (CLI).This study sought develop BOLD-CMR as an objective, reliable clinical tool for measuring calf muscle CLI.The was imaged at 3-T young healthy control subjects (n = 12), age-matched 10), CLI 34). Signal intensity time curves...