A5064574268- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Liver Disease Diagnosis and Treatment
- Coronary Interventions and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- MRI in cancer diagnosis
- Cardiovascular Function and Risk Factors
- Spine and Intervertebral Disc Pathology
- Cardiovascular Health and Disease Prevention
- Metabolomics and Mass Spectrometry Studies
- Atherosclerosis and Cardiovascular Diseases
- Adipose Tissue and Metabolism
- Congenital Heart Disease Studies
- Diet and metabolism studies
- Cardiovascular Disease and Adiposity
- Phytochemicals and Antioxidant Activities
- Radiomics and Machine Learning in Medical Imaging
- AI in cancer detection
- Diagnosis and Treatment of Venous Diseases
- Aortic Disease and Treatment Approaches
- Medical Image Segmentation Techniques
- Aortic aneurysm repair treatments
- Advanced Neuroimaging Techniques and Applications
- Liver Disease and Transplantation
Pontificia Universidad Católica de Chile
2016-2025
Baptist Hospital of Miami
2025
Millennium Institute for Integrative Biology
2023-2025
Intelligent Health (United Kingdom)
2024
Millennium Institute
2024
King's College London
2010-2023
Millennium Science Initiative
2019-2023
St Thomas' Hospital
2011-2019
Laboratoire d’Imagerie Biomédicale
2011-2019
Imaging Center
2011-2019
Endothelial dysfunction promotes atherosclerosis and precedes acute cardiovascular events. We investigated whether in vivo magnetic resonance imaging with the use of an albumin-binding contrast agent, gadofosveset, could detect endothelial damage associated apolipoprotein E-deficient (ApoE(-/-)) mice. Furthermore, we tested noninvasively assess function by measuring endothelial-dependent vasodilation response to acetylcholine.ApoE(-/-) mice were imaged at 4, 8, 12 weeks after commencement a...
Abstract Chile's gallbladder cancer rates are among the highest in world, being leading cause of deaths Chilean women. To provide insights into etiology cancer, we conducted an ecologic study examining geographical variation and several putative risk factors. The relative dying from between 1985 2003 was estimated for each 333 counties, using a hierarchical Poisson regression model, adjusting age, sex location. mortality analyzed relation to region, poverty, Amerindian (Mapuche) population,...
We assessed population incidence rates 1998-2002 and 5-year survival of 317 primary gallbladder cancer (GBC) entered in the population-based registry Valdivia. analyzed GBC (Poisson regression) (Cox regression). Cases were identified by histology (69.4%), clinical work-up (21.8%), or death certificate only (8.8%). Main symptoms abdominal pain (82.8%), jaundice (53.6%) nausea (42.6%), weight loss (38.2%); at diagnosis, 64% had Stage TNM IV. In period, 4% histopathological studies from...
The magnetic resonance longitudinal relaxation time (T1) changes with thrombus age in humans. In this study, we investigate the possible mechanisms that give rise to T1 signal venous thrombi and whether are informative of susceptibility lysis.Venous thrombosis was induced vena cava BALB/C mice, temporal correlated composition. mean shortest at 7 days following induction returned blood as resolved. related methemoglobin formation further processing. Studies inducible nitric oxide synthase...
AIM:To study the incidence and survival rate of stomach cancer (SC) its associated factors in a high risk population Chile. METHODS:The population-based registry Valdivia, included International Agency for Research on Cancer system, covers 356 396 residents Valdivia Province, Southern Chile.We studied all SC cases entered this Registry during 1998-2002 (529 cases).Population data came from Chilean census (2002).Standardized rates per 100 000 inhabitants (SIR) using world population,...
Objective— Deep venous thrombosis is a major health problem. Thrombolytic therapies are effective in recanalizing the veins and preventing post-thrombotic complications, but there no consensus on selection criteria. The aim of this study was to investigate fibrin-specific MRI contrast agent (EP-2104R) for accurate quantification thrombus’ fibrin content vivo identification thrombus suitable thrombolysis. Approach Results— Venous induced inferior vena cava 8- 10-week-old male BALB/C mice...
Several 2D methods have been proposed to estimate WSS and OSI from PC-MRI, neglecting the longitudinal velocity gradients that typically arise in cardiovascular flow, particularly on vessel geometries whose cross section centerline orientation strongly vary axial direction. Thus, contribution of remains understudied. In this work, we propose a 3D finite-element method for quantification 3D-CINE PC-MRI accounts both in-plane gradients. We demonstrate convergence robustness cylindrical using...
Abstract Background Combining venetoclax with a hypomethylating agent (HMA) is standard of care in Acute Myeloid Leukemia (AML) ineligible for intensive chemotherapy. However, this associated prolonged neutropenia, potentially increasing the risk invasive fungal infections (IFI). The necessity antifungal prophylaxis context remains unclear, particularly regions like southeastern United States, where humid climate may contribute to higher overall rates IFIs. Methods A retrospective,...
Magnetic resonance spectroscopy identifies increased cholesterol and changes in fatty acid distribution as key biomarkers for liver damage NPC disease, offering potential non-invasive patient monitoring through distinct metabolite spectra.
Background— Deep vein thrombosis remains a major health problem necessitating accurate diagnosis. Thrombolysis is associated with significant morbidity and effective only for the treatment of unorganized thrombus. We tested feasibility in vivo magnetization transfer (MT) diffusion-weighted magnetic resonance imaging to detect thrombus organization murine model deep thrombosis. Methods Results— was induced inferior vena cava male BALB/C mice. Magnetic performed at days 1, 7, 14, 21, 28 after...
Optimal healing of the myocardium following myocardial infarction (MI) requires a suitable degree inflammation and its timely resolution, together with well-orchestrated deposition degradation extracellular matrix (ECM) proteins.
There are conflicting data regarding whether netrin-1 retards or accelerates atherosclerosis progression, as it can lead either to monocyte repulsion from retention within plaques depending on its cellular source. We investigated the effect of aspirin, which is widely used in cardiovascular prophylaxis, synthesis different isoforms by endothelial cells under pro-inflammatory conditions, and defined net aspirin-dependent systemic modulation progression.Netrin-1 was studied vitro using human...
A healthy dietary pattern and high quality nutrient intake reduce atherosclerotic cardiovascular disease risk. Red wine grape pomace (RWGP)—a rich natural source of fiber antioxidants—appears to be a potential functional food ingredient. The impact supplementation with RWGP flour was evaluated in atherogenic diet-fed SR-B1 KO/ApoER61h/h mice, model lethal ischemic heart disease. mice were fed (high fat, cholesterol, cholic acid, HFC) diet supplemented with: (a) 20% chow (HFC-Control), (b)...
Nonalcoholic fatty liver disease (NAFLD) is a major cause of morbidity and mortality worldwide. Additional therapies using functional foods dietary supplements have been investigated used in clinical practice, showing them to be beneficial. Honeybee pollen from Chile has shown large concentration phenolic compounds high antioxidant activity. In this work, we characterized twenty-eight bee extracts the central zone according botanical origin, profile, quercetin concentration, activity (FRAP...
Chickpeas are rich sources of bioactive compounds such as phenolic acids, flavonoids, and isoflavonoids. However, the contribution insoluble-bound phenolics to their antioxidant properties remains unclear. Four varieties chickpeas were evaluated for presence soluble (free esterified) well antiradical activity, reducing power inhibition peroxyl-induced cytotoxicity in human HuH-7 cells. In general, fraction showed a higher total content. Phenolic isoflavonoids identified quantified by...
Purpose To assess the variability of peak flow, mean velocity, stroke volume, and wall shear stress measurements derived from 3D cine phase contrast (4D flow) sequences under different conditions spatial temporal resolutions. Methods We performed controlled experiments using a thoracic aortic phantom. The phantom was connected to pulsatile flow pump, which simulated nine physiological conditions. For each condition, 4D data were acquired with 2D highest available spatio‐temporal resolution...