A5029885724- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Hormonal Regulation and Hypertension
- Estrogen and related hormone effects
- Cancer, Lipids, and Metabolism
- Ovarian function and disorders
- Folate and B Vitamins Research
- Pancreatic function and diabetes
- MicroRNA in disease regulation
- Gestational Diabetes Research and Management
- Reproductive Biology and Fertility
- Dietary Effects on Health
- Liver Disease Diagnosis and Treatment
- Diabetes and associated disorders
- Antioxidant Activity and Oxidative Stress
- Diabetes Management and Research
- Peroxisome Proliferator-Activated Receptors
- Adipokines, Inflammation, and Metabolic Diseases
- Therapeutic Uses of Natural Elements
- Mesenchymal stem cell research
- Inflammatory Bowel Disease
- Phytochemicals and Antioxidant Activities
- Cholesterol and Lipid Metabolism
- Ginkgo biloba and Cashew Applications
- Growth Hormone and Insulin-like Growth Factors
University of O'Higgins
2020-2024
University of Chile
2012-2022
Universidad de Navarra
2019-2021
Pontificia Universidad Católica de Chile
2015-2019
It is well established that type 1 diabetes (T1D) an autoimmune disease. Controversial data exists regarding the differential control of immune system in T1D patients compared to unaffected individuals. MicroRNAs (miRNAs) are involved gene expression (by negative regulation at post-transcriptional level, by mediating translational repression or degradation mRNA targets). Their potential role T cell activation and autoimmunity controversial.We investigated profile miR-21a miR-93 PMC samples...
Changes in gut microbiota composition and epigenetic mechanisms have been proposed to play important roles energy homeostasis, the onset development of obesity. However, crosstalk between markers microbiome obesity remains unclear. The main objective this study was establish a link DNA methylation patterns subjects with by identifying differentially methylated regions (DMRs) that could be potentially regulated microbiota. bacterial sequencing analysis were performed on 342 BMI 18 40 kg/m2....
Abstract Introduction Type 1 diabetes (T1D) has a complex etiology in which genetic and environmental factors are involved, whose interactions have not yet been completely clarified. In this context, the role PD‐1 pathway its ligands 2 (PD‐L1 PD‐L2) proposed as candidates several autoimmune diseases. The aim of work was to determine allele haplotype frequency six gene polymorphisms PD‐ligands Chilean T1D patients their effect on serum levels PD‐L1 autoantibody profile (GAD65 IA2). Methods...
A healthy dietary pattern and high quality nutrient intake reduce atherosclerotic cardiovascular disease risk. Red wine grape pomace (RWGP)—a rich natural source of fiber antioxidants—appears to be a potential functional food ingredient. The impact supplementation with RWGP flour was evaluated in atherogenic diet-fed SR-B1 KO/ApoER61h/h mice, model lethal ischemic heart disease. mice were fed (high fat, cholesterol, cholic acid, HFC) diet supplemented with: (a) 20% chow (HFC-Control), (b)...
Aging is the main risk factor for most chronic diseases.Epigenetic mechanisms, such as DNA methylation (DNAm) plays a pivotal role in regulation of physiological responses that can vary along lifespan.The aim this research was to analyze association between leukocyte DNAm genes involved longevity and occurrence obesity related metabolic alterations an adult population.Subjects from MENA cohort (n=474) were categorized according age (<45 vs 45>) presence alterations: increased waist...
Clinical and experimental evidences indicate that epigenetic modifications induced by the prenatal environment are related to metabolic reproductive derangements in polycystic ovary syndrome (PCOS). Alterations leptin adiponectin systems, androgen signalling antimüllerian hormone (AMH) levels have been observed PCOS women their offspring. Using a targeted Next-Generation Sequencing (NGS), we studied DNA methylation promoter regions of (LEP), receptor (LEPR), (ADIPOQ), 1 2 (ADIPOR1 ADIPOR2),...
Rodent models in rats, mice, and guinea pigs have been extremely helpful to gain insight into pregnancy physiology pathologies-related. Moreover, they allowed understanding the mechanism that links an adverse intrauterine environment with origin of adult disease. In this regard, effects diverse maternal conditions, such as undernutrition, obesity, hypoxia, hyperandrogenism on placental function its long-term consequences for offspring, widely analyzed through rodents involving dietary...
Methylation in CpG sites of the PPARGC1A gene (encoding PGC1-α) has been associated with adiposity, insulin secretion/sensitivity indexes and type 2 diabetes. We assessed association between methylation profile promoter leukocytes normoglycemic women. A standard oral glucose tolerance test (OGTT) an abbreviated version intravenous (IVGTT) were carried out n = 57 Chilean nondiabetic women measurements plasma glucose, insulin, C-peptide. Bisulfite-treated DNA from was evaluated for levels six...
Differentially methylated regions (DMR) are genomic with different methylation status. The aim of this research was to identify DMRs in subjects obesity that predict the response a weight-loss dietary intervention and its association metabolic variables. Based on change body mass index (BMI), 201 overweight were categorized tertiles according their hypocaloric diet: Responders (R; n = 64) Non-Responders (NR; 63). R group lost 4.55 ± 0.91 BMI units (kg/m2) NR 1.95 0.73 kg/m2 (p < 0.001). DNA...
Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women of reproductive age. Many with PCOS have been found to an unbalanced diet and deficiencies in essential nutrients. This study aimed assess the levels folate vitamin B12 (B12) their relationship metabolic factors PCOS. Anthropometric, clinical, genetic analyses were conducted evaluate markers related one-carbon metabolism control group. The group had higher BMI HOMA-IR (1.7 vs. 3.1; p < 0.0001). HDL...
The high-density lipoprotein receptor SR-B1 mediates cellular uptake of several lipid species, including cholesterol and vitamin E. During early mouse development, is located in the maternal-fetal interface, where it facilitates E transport towards embryo. Consequently, embryos lacking are E-deficient, around half them fail to close neural tube show cephalic defects (NTD). Here, we used transcriptomic profiling identify molecular determinants this phenotypic difference between deficient with...
Circulating microRNAs (miRNAs) are valuable biomarkers that may provide important insight into the pathogenesis of metabolic syndrome (MetS). Moreover, there is an association between chronotypical characteristics and MetS predisposition. Considering expression some miRNAs circadian-rhythm-dependent, aim this study was to investigate circulating miRNA profile in subjects with without chronotype. The 86 syndrome-related investigated plasma 21 82 using miRCURY LNA PCR System technology....
Polycystic Ovary Syndrome (PCOS) is a complex hormonal disorder that associated with heightened metabolic risks. While oxidative stress (OS) known to play role in PCOS, the precise nature of relationship between PCOS and increased OS remains not entirely understood. Combined oral contraceptives (COCs) are first-line treatment regulate menstrual cycles androgen levels, but their impact on requires further study. We conducted transcriptomic analysis using RNAseq assessed levels various markers...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)