A5088576969- Nutritional Studies and Diet
- Sphingolipid Metabolism and Signaling
- Obesity, Physical Activity, Diet
- Inflammatory Bowel Disease
- Birth, Development, and Health
- Diet and metabolism studies
- Lipid metabolism and disorders
- IL-33, ST2, and ILC Pathways
- Gestational Diabetes Research and Management
- Adipose Tissue and Metabolism
- Bariatric Surgery and Outcomes
- Health and Lifestyle Studies
- Erythrocyte Function and Pathophysiology
- Gut microbiota and health
- Microscopic Colitis
- Caveolin-1 and cellular processes
- Nutrition, Health and Food Behavior
- Antioxidant Activity and Oxidative Stress
- Sleep and related disorders
- Diabetes Management and Education
- Adipokines, Inflammation, and Metabolic Diseases
- Child Nutrition and Water Access
- Fatty Acid Research and Health
- Consumer Attitudes and Food Labeling
- Diabetes, Cardiovascular Risks, and Lipoproteins
Pontificia Universidad Católica de Chile
2014-2024
Millennium Institute on Immunology and Immunotherapy
2018-2019
Objective Infants born from overweight and obese mothers with glucose-controlled gestational diabetes (GDM) tend to be large-for-gestational age (LGA). It is hypothesized that this due an excessive rise in maternal triglyceride levels. Methods Two-hundred seventy nine singleton GDM pregnancies were divided into three groups according prepregnancy BMI: normal weight (BMI = 20–24.9; n 128), 25–29.9; 105), ≥ 30; 46). Individual z-scores (ZS) of triglycerides newborn (NWZS) calculated as...
The main environmental risk factor associated with the development of Crohn's disease (CD) is cigarette smoking. Although mechanism still unknown, some studies have shown that exposure affects intestinal barrier small bowel. Among factors may be involved in this process are Paneth cells. These specialized epithelial cells located into intestine, and they able to secrete antimicrobial peptides, having an essential role control growth microorganisms. Alterations its function inflammatory...
Sphingolipids are components of cell membrane structure, but also circulate in serum and essential mediators many cellular functions. While ceramides have been proposed previously as a useful biomarker for cardiometabolic disease, the involvement other sphingolipids is still controversial. The aim this study was to investigate cross-sectional association between blood sphingolipidomic profiles metabolic syndrome (MetS) well atherosclerotic risk factors large population-based U.S.Clinical...
High-density lipoprotein (HDL) plays a critical role in protection against atherosclerosic and cardiovascular disease (ASCVD). In addition to contributing clearing excess vascular cholesterol, HDL particles exhibit antioxidative functions, helping attenuate adverse effects of oxidized low-density lipoproteins. However, these beneficial properties can be undermined by oxidative stress, inflammation, unhealthy lifestyles diet, as well influenced race sex. Thus, when assessing risk, it is...
Infectious diarrhea can be caused by a large number of microorganisms including bacteria virus and parasites. The clinical syndromic approach has been traditionally used to guide therapy. aim this study was characterize the etiology acute FilmArray GI panel correlate it with its presentation in an adult population presenting emergency room developing country.Adult patients attending ER due were selected. All included had performed characteristics recorded.One hundred ninety-nine included....
Abstract Emerging research has linked psychological well-being with many physiological markers as well morbidity and mortality. In this analysis, the relationship between components of eudaimonic serum sphingolipids levels was investigated using data from a large national survey middle-aged American adults (Midlife in United States). Health behaviors (i.e., diet, exercise, sleep) were also examined potential mediators these relationships. Serum total ceramides—the main molecular class...
High sense of purpose in life, a fundamental domain eudaimonic well-being, has been consistently associated with lower risk for various obesity-related chronic diseases. Although this psychological feature correlates some health behaviors as potential mediators, its association healthy eating remains less explored. In addition, studies these psycho-behavioral and relationships the South American population are lacking. This research sought to assess: (1) cross-sectional between self-reported...
The susceptibility to develop atherosclerosis is increased by intrauterine growth restriction and prenatal exposure maternal hypercholesterolemia. Here, we studied whether mouse gestational hypercholesterolemia affected fetal development at different stages of gestation. Female LDLR KO mice fed a proatherogenic, high cholesterol (HC) diet for 3 weeks before conception during pregnancy exhibited significant increase in non-HDL developed atherosclerosis. At embryonic days 12.5 (E12.5), E15.5,...
Psychosocial status and lifestyle are key risk factors of non-communicable diseases (NCDs), which, in turn, main drivers healthcare costs morbimortality worldwide, including Chile. Mediterranean diet (MedDiet) is one the healthiest dietary patterns under study. However, its impact on high-risk conditions, such as metabolic syndrome (MetS), NCDs outside Basin remains mostly unexplored. Even though Central Chile has an environment, food production, culinary traditions comparable to those...
Paneth cells (PCs) are specialized epithelial of the small bowel that contain multiple secretory granules filled with antimicrobial peptides and trophic factors, which essential for control microorganisms growth maintaining intestinal integrity. Alterations in their function associated an imbalance normal microbiota, gastrointestinal infections inflammatory processes, such as Crohn's disease (CD). One most common murine models studying CD is IL-10-/- mouse. mice when housed conventional...
Abstract Background Type 2 diabetes (T2D) has become a worldwide pandemic. While ceramides may serve as intermediary between obesity-related lipotoxicity and T2D, the relationship with simple glycosphingolipids remains uncertain. The aim of this study was to characterize associations blood glycosphingolipid ceramide species T2D identify circulating sphingolipid profile that could novel biomarker for risk. Methods Cross-sectional levels, insulin resistance, prevalence were evaluated in 2,072...
The aim of this study was to identify the blood lipidomic profile associated with a healthy eating pattern in middle-aged US population sample and determine its relationship metabolic disorders cardiovascular risk (CVR).
Background: a healthy food intake pattern, specifically the Mediterranean diet (MedDiet), is factor associated with reduced risk, lower prevalence, and better management of chronic diseases. However, there limited information regarding how patients integrate proposals for adherence to this pattern in their daily lives. Objective: identify factors conditions that influence MedDiet Chile. Methods: an exploratory qualitative study was applied 35 65-year-old both sexes who presented at least one...
<sec> <title>BACKGROUND</title> An unhealthy diet ranks among the top contributors to burden of noncommunicable chronic disease and death in US, highlighting importance evaluating quality population-based studies, such as MIDUS (Midlife United States) cohort. </sec> <title>OBJECTIVE</title> 1) To develop a simple tool (MIDUS healthy eating index (MIDUS-HEI)) evaluate more broadly consistently subjects enrolled at different time points study, 2) use this score assessing cross-sectional...
Abstract Emerging research has linked psychological well-being with many physiological markers as well morbidity and mortality. In this analysis, the relationship between components of eudaimonic serum sphingolipids levels was investigated using data from a large national survey middle-aged American adults (Midlife in United States). Health behaviors (i.e., diet, exercise, sleep) were also examined potential mediators these relationships. Serum total ceramides - main molecular class...