A5021373304- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- COVID-19 Clinical Research Studies
- Viral gastroenteritis research and epidemiology
- Gut microbiota and health
- Digestive system and related health
- Heme Oxygenase-1 and Carbon Monoxide
- Salmonella and Campylobacter epidemiology
- Immune Response and Inflammation
- Probiotics and Fermented Foods
- Helicobacter pylori-related gastroenterology studies
- Systemic Lupus Erythematosus Research
- Bacteriophages and microbial interactions
- Antimicrobial Peptides and Activities
- Diet and metabolism studies
- Immune cells in cancer
- Thyroid Disorders and Treatments
- Inflammatory Bowel Disease
- Pediatric health and respiratory diseases
- Thermal Regulation in Medicine
- Respiratory viral infections research
- Cannabis and Cannabinoid Research
- Multiple Sclerosis Research Studies
- Autophagy in Disease and Therapy
- Herpesvirus Infections and Treatments
Millennium Institute on Immunology and Immunotherapy
2018-2025
Pontificia Universidad Católica de Chile
2018-2025
The development of effective vaccines against coronavirus disease 2019 is a global priority. CoronaVac an inactivated severe acute respiratory syndrome 2 (SARS-CoV-2) vaccine with promising safety and immunogenicity profiles. This article reports results obtained for healthy Chilean adults aged ≥18 years in phase 3 clinical trial.Volunteers randomly received doses or placebo, separated by weeks. A total 434 volunteers were enrolled, 397 18-59 37 ≥60 years. Solicited unsolicited adverse...
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible of current pandemic ongoing all around world. Since its discovery in 2019, several circulating variants have emerged and some them are associated with increased infections death rate. Despite genetic differences among these variants, vaccines approved for human use shown a good immunogenic protective response against them. In Chile, over 70% vaccinated population immunized CoronaVac, an...
Constant efforts to prevent infections by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are actively carried out around the world. Several vaccines currently approved for emergency use in population, while ongoing studies continue provide information on their safety and effectiveness. CoronaVac is an inactivated SARS-CoV-2 vaccine with a good immunogenicity profile as seen phase 1, 2, 3 clinical trials world, effectiveness of 65.9% symptomatic cases. Although vaccination...
The ongoing COVID-19 pandemic has had a significant impact worldwide, with an incommensurable social and economic burden. rapid development of safe protective vaccines against this disease is global priority. CoronaVac vaccine prototype based on inactivated SARS-CoV-2, which shown promising safety immunogenicity profiles in pre-clinical studies phase 1/2 trials China. To day, four 3 clinical are Brazil, Indonesia, Turkey, Chile. This article reports the results obtained subgroup participants...
CoronaVac is an inactivated SARS-CoV-2 vaccine approved by the World Health Organization (WHO). Previous studies reported increased levels of neutralizing antibodies and specific T cells 2 4 weeks after two doses CoronaVac; these were significantly reduced at 6 to 8 months doses. Here, we report effect a booster dose on anti-SARS-CoV-2 immune response generated against variants concern (VOCs), Delta Omicron, in adults participating phase III clinical trial Chile. Volunteers immunized with...
Neutrophils are immune cells classically defined as pro-inflammatory effector cells. However, current accumulated evidence indicates that neutrophils have more versatile immune-modulating properties. During acute lung infection with Streptococcus pneumoniae in mice, interleukin-10 (IL-10) production is required to temper an excessive injury and improve survival, yet the cellular source of IL-10 immunomodulatory role during S. remain unknown. Here we show main myeloid produce lungs first 48 h...
Carbapenem-resistant Klebsiella pneumoniae sequence type 258 (CRKP-ST258) can cause chronic infections in lungs and airways, with repeated episodes of bacteremia. In this report we addressed whether the recruitment myeloid cells producing anti-inflammatory cytokine interleukin-10 (IL-10) modulates clearance CKRP-ST258 establishes bacterial persistence. Our data demonstrate that during pneumonia caused by a clinical isolate CRKP-ST258 (KP35) there is an early monocyte-myeloid-derived...
Respiratory infections are one of the leading causes morbidity and mortality worldwide, mainly in children, immunocompromised people, elderly. Several respiratory viruses can induce intestinal inflammation alterations microbiota composition. Human metapneumovirus (HMPV) is major contributing to infant children under 5 years age effect this infection at gut level has not been studied. Here, we evaluated distal effects HMPV on a murine model, analyzing several post-infection times (days 1, 3,...
Background: The development of vaccines to control the coronavirus disease 2019 (COVID-19) pandemic progression is a worldwide priority. CoronaVac an inactivated severe acute respiratory syndrome 2 (SARS-CoV-2) vaccine approved for emergency use with robust efficacy and immunogenicity data reported in trials China, Brazil, Indonesia, Turkey, Chile. Methods: This study randomized, multicenter, controlled phase 3 trial healthy Chilean adults aged ≥18 years. Volunteers received two doses...
Pathogenicity island excision is a phenomenon that occurs in several Salmonella enterica serovars and other members of the family Enterobacteriaceae. ROD21 an excisable pathogenicity found chromosome S. Enteritidis, Dublin Typhi among others, which contain genes encoding virulence-associated proteins. Excision may play role ability Enteritidis to cause systemic infection mice. Our previous studies have shown strains unable excise display reduced colonize liver spleen. In this work, we...
Multiple sclerosis (MS) is an increasingly prevalent progressive autoimmune and debilitating chronic disease that involves the detrimental recognition of central nervous system (CNS) antigens by immune system. Although significant progress has been made in last decades on biology MS identification novel therapies to treat its symptoms, etiology this remains unknown. However, recent studies have suggested viral infections may contribute onset. Interestingly, a potential association between...
Abstract Background CoronaVac ® is an inactivated SARS-CoV-2 vaccine approved by the World Health Organization. Previous studies reported increased levels of neutralizing antibodies and specific T cells two- four-weeks after two doses , but are reduced at six to eight months doses. Here we report effect a booster dose on anti-SARS-CoV-2 immune response generated against variants concern (VOC) Delta Omicron in adults participating phase 3 clinical trial Chile. Methods Volunteers immunized...
Paneth cells (PCs) are specialized epithelial of the small bowel that contain multiple secretory granules filled with antimicrobial peptides and trophic factors, which essential for control microorganisms growth maintaining intestinal integrity. Alterations in their function associated an imbalance normal microbiota, gastrointestinal infections inflammatory processes, such as Crohn's disease (CD). One most common murine models studying CD is IL-10-/- mouse. mice when housed conventional...
An important virulence trait of Salmonella enterica serovar Typhimurium (S. Typhimurium) is the ability to avoid host immune response, generating systemic and persistent infections. Host cells play a crucial role in bacterial clearance by expressing enzyme heme oxygenase 1 (Hmox1), which catalyzes degradation groups into Fe2+, biliverdin, carbon monoxide (CO). The Hmox1 activity during S. infection not clear previous studies have shown contradictory results. We evaluated effect pharmacologic...
Excisable genomic islands (EGIs) are horizontally acquired genetic elements that harbor an array of genes with diverse functions. ROD21 is EGI found integrated in the chromosome Salmonella enterica serovar Enteritidis (Salmonella ser. Enteritidis). While this island known to be involved capacity cross epithelial barrier and colonize sterile organs, role most remains unknown, thus, identification their function fundamental understanding impact on bacterium pathogenicity. Therefore, study, we...
Abstract Background The development of vaccines to control the COVID-19 pandemic progression is a worldwide priority. CoronaVac ® an inactivated SARS-CoV-2 vaccine approved for emergency use with robust efficacy and immunogenicity data reported in trials China, Brazil, Indonesia, Turkey, Chile. Methods This study randomized, multicenter, controlled phase 3 trial healthy Chilean adults aged ≥18 years. Volunteers received two doses separated by (0-14 schedule) or four weeks (0-28 schedule)....