A5089700263- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- Viral gastroenteritis research and epidemiology
- Hepatitis Viruses Studies and Epidemiology
- Long-Term Effects of COVID-19
- Viral Infections and Immunology Research
- Meta-analysis and systematic reviews
- Healthcare cost, quality, practices
- Infection Control in Healthcare
- scientometrics and bibliometrics research
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical industry and healthcare
- Protein Degradation and Inhibitors
- Healthcare Policy and Management
- Medical Device Sterilization and Disinfection
- Public Health and Social Inequalities
- Health Sciences Research and Education
- Contact Dermatitis and Allergies
- Empathy and Medical Education
- Lung Cancer Research Studies
- Antibiotic Use and Resistance
- Social Sciences and Policies
- Health and Medical Research Impacts
- Healthcare Systems and Technology
Pontificia Universidad Católica de Chile
2021-2023
Universidad de Santiago de Chile
2018-2023
Red de Investigación Cardiovascular
2023
Universidad de Ciencias Medicas
2019
Universidad Bernardo O'Higgins
2019
University of Chile
2015-2016
Universidad Independiente
2013
Fundación Chile
2007
Constant efforts to prevent infections by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are actively carried out around the world. Several vaccines currently approved for emergency use in population, while ongoing studies continue provide information on their safety and effectiveness. CoronaVac is an inactivated SARS-CoV-2 vaccine with a good immunogenicity profile as seen phase 1, 2, 3 clinical trials world, effectiveness of 65.9% symptomatic cases. Although vaccination...
CoronaVac is an inactivated SARS-CoV-2 vaccine approved by the World Health Organization (WHO). Previous studies reported increased levels of neutralizing antibodies and specific T cells 2 4 weeks after two doses CoronaVac; these were significantly reduced at 6 to 8 months doses. Here, we report effect a booster dose on anti-SARS-CoV-2 immune response generated against variants concern (VOCs), Delta Omicron, in adults participating phase III clinical trial Chile. Volunteers immunized with...
•The built hospital environment serves as a significant and continuous reservoir of microbes capable colonizing infecting patients.•Cleaning, hand hygiene, infection control bundles while effective cannot completely eliminate this risk.•Augmenting the with continuously active antimicrobial surfaces fabricated from U.S. Environmental Protection Agency–registered copper can significantly lower microbial burden, helping to augment existing strategies.•Addition limited number copper-surfaced...
BackgroundThe Omicron variant has challenged the control of COVID-19 pandemic due to its immuno-evasive properties. The administration a booster dose SARS-CoV-2 vaccine showed positive effects in immunogenicity against SARS-CoV-2, effect that is even enhanced after second booster.MethodsDuring phase-3 clinical trial, we evaluated CoronaVac®, an inactivated administered 6 months first booster, neutralization (n = 87). In parallel, cellular immunity 45) was analyzed stimulated peripheral...
Potential cost effectiveness of a rotavirus vaccine in ChileBackground: Cost studies are essential to assess the real value interventions with preventive or therapeutic objectives.Aim: To theoretical costeffectiveness against Chilean children less than five years age.Material and methods: An economic model was developed based on information disease incidence, health care costs associated treatment vaccination.Net vaccination were estimated from system perspective compared life...
Background: The development of vaccines to control the coronavirus disease 2019 (COVID-19) pandemic progression is a worldwide priority. CoronaVac an inactivated severe acute respiratory syndrome 2 (SARS-CoV-2) vaccine approved for emergency use with robust efficacy and immunogenicity data reported in trials China, Brazil, Indonesia, Turkey, Chile. Methods: This study randomized, multicenter, controlled phase 3 trial healthy Chilean adults aged ≥18 years. Volunteers received two doses...
Background: Incorporation of new rotavirus vaccines into national programs developing countries will rely on well-designed cost-effective analysis based accurate assessment disease burden. For Chile, burden is determined mostly by outpatient clinic and emergency room visits hospitalizations. We previously estimated a yearly incidence 8000 53,000 hospitalizations respectively for children ≤3 years age. Objective: The objective this study was to quantify the impact as cause visits. Methods: A...
University ranking systems and the publish-or-perish dictum, among other factors, are driving universities researchers around world to increase their research productivity. Authors frequently report multiple affiliations in published articles. It is not known if reported institutional real affiliations, which when have contributed substantially conducted manuscript. This study aims establish whether there an empirical basis for author affiliation misrepresentation authors with...
Universal health coverage assessment based on national socioeconomic
Abstract Background CoronaVac ® is an inactivated SARS-CoV-2 vaccine approved by the World Health Organization. Previous studies reported increased levels of neutralizing antibodies and specific T cells two- four-weeks after two doses , but are reduced at six to eight months doses. Here we report effect a booster dose on anti-SARS-CoV-2 immune response generated against variants concern (VOC) Delta Omicron in adults participating phase 3 clinical trial Chile. Methods Volunteers immunized...
University ranking systems and the publish‐or‐perish dictum are driving universities researchers around world to increase their research productivity publication outputs. There is no regulated checking of author affiliations as authors expected only include that have contributed substantially conducted published manuscript. Our study aims establish whether can be validated if there evidence misrepresentation from who report multiple institutional affiliations. We an exploratory case on...
Introduction Quality of reporting refers to how published articles communicate the research was done and what found. Gaps imprecisions hamper assessment methodological quality internal external validity. The CONsolidated Standards Reporting Trials (CONSORT) are a set evidence-based recommendations minimum elements be included in randomised controlled trials (RCTs) ensure complete transparent account done, it Few studies have been conducted on impact CONSORT RCTs Latin American Spanish...
The COmmunity Cohort Study aims to determine, after natural exposure SARS-CoV-2 or anti-SARS-CoV-2 vaccines deployed in Chile prevent COVID-19 the context of current pandemic, strength and duration detectable neutralising antibodies adult ambulatory primary care patients with cardiovascular risk factors.
Summary The SARS-CoV-2 Omicron variant has challenged the control of COVID-19 pandemic even in highly vaccinated countries. While a second booster mRNA vaccines improved immunity against SARS-CoV-2, humoral and cellular responses induced by an inactivated vaccine have not been studied. In context phase 3 clinical study, we report that CoronaVac ® increased neutralizing response ancestral virus yet showed poor neutralization variant. Additionally, isolated PBMCs displayed equivalent...
Incidence of severe rotavirus gastroenteritis among Chilean children under three years age Background: Rotavirus infections account every year in Chile, for approximately 53,000 emergency consultations and 8,000 hospital admissions age.Aim: To estimate incidence rates <3 age, living the V VIII Regions to identify predominant viral serotypes.Material methods: A prospective hospital-based surveillance was implemented public private hospitals Viña del Mar Valparaíso (Region V) Chiguayante,...
Introducción En diciembre de 2019 surge un nuevo coronavirus que resultó en una pandemia consecuencias devastadoras. Chile activó dispositivos detección, aislamiento precoz los casos sospechosos y mandató medidas distanciamiento físico. Además, se gestionó rápido proceso inmunización, estableciendo grupos prioritarios según riesgo exposición complicación. A pesar todos avances la ciencia sobre covid-١٩, aún existen limitaciones el conocimiento dinámica significación clínica respuesta humoral...
Based on the recommendations of Vaccine Advisory Committee and National Immunization Program, Chile implemented an early vaccination process population with vaccines from different laboratories. The study neutralizing antibody levels in subgroups contributes to establishment correlates protection against SARS-CoV-2 infection. In 2022 2023 we set up a community cohort 914 adults cardiovascular risk factors. this are measuring humoral immune response exposure antigens, either by or infection,...
A well-informed diagnostic process results in better health outcomes and less overdiagnosis. While there have been studies conducted to explore doctors' knowledge, attitudes, practice regarding test information, are no reports from Latin America. We invited physician readers of a American medical journal answer survey on their professional demographic characteristics previous exposure information training. Two hundred fifteen responded, whom 88% agreed some extent that is helpful for...