A5037439612- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Respiratory viral infections research
- Vaccine Coverage and Hesitancy
- Tuberculosis Research and Epidemiology
- Virology and Viral Diseases
- Infective Endocarditis Diagnosis and Management
- Influenza Virus Research Studies
- Child and Adolescent Health
- Hepatitis Viruses Studies and Epidemiology
- Viral gastroenteritis research and epidemiology
- Hepatitis B Virus Studies
- Immunodeficiency and Autoimmune Disorders
- Streptococcal Infections and Treatments
- Hepatitis C virus research
- Educational Innovations and Technology
- Migration, Health and Trauma
- Congenital Anomalies and Fetal Surgery
- Climate Change and Health Impacts
- SARS-CoV-2 and COVID-19 Research
- Pediatric health and respiratory diseases
- Maternal and Neonatal Healthcare
- Public Health and Environmental Issues
- Interpreting and Communication in Healthcare
- Gastrointestinal disorders and treatments
San Sebastián University
2023-2025
Universidad de Los Andes, Chile
2015-2024
Universidad de Los Andes
2011-2023
Universidad Nacional Autónoma de México
2021-2022
University of the Andes
2020
Instituto de Salud Pública de Chile
1984-2019
Universidad de Los Andes
2007-2018
Public Health Department
2015
Dow Chemical (India)
2010
University of Chile
2000-2007
We previously demonstrated the immunogenicity and tolerability of serogroup B meningococcal vaccine, 4CMenB (Bexsero®), in 11−17 y-olds randomized to receive 1, 2, or 3 doses at 6 mo intervals. Participants this extension study provided an additional blood sample 18−24 after last vaccine dose, assess persistence serum bactericidal activity with human complement (hSBA), compare age-matched 4CMenB-naïve controls.In original study, one month 93% subjects had seroprotective hSBA titers (≥4)...
<ns4:p>Introduction Zero-dose children (ZDC) are defined as those that have never been reached by routine immunization services. In Latin America, almost 2.7 million infants younger than 1 year of age, incomplete vaccination schedules, and vaccine preventable diseases such measles or polio increase worldwide. ZDC reported to reside in high risk fragile settings, including remote-rural areas, urban slums, conflict-affected areas. Identifying the problem settings each country is mandatory...
Background The ten-valent pneumococcal conjugate vaccine (PCV10) was introduced into the Chilean National Immunization Program (NIP) in January 2011 with a 3+1 schedule (2, 4, 6 and 12 months) without catch-up vaccination. We evaluated effectiveness of PCV10 on pneumonia morbidity mortality among infants during first two years after introduction. Methods This is population-based nested case-control study using four merged nationwide case-based electronic health data registries: live birth,...
Background. A need for updated information on different aspects of idiopathic intussusception resurged after the Rotashield experience. Variability incidence rates worldwide and possibility a more severe outcome among infants that have at younger age are two issues remain unclear. We aimed to provide clinical in large population Chilean children <2 years age, including best estimate rate comparative analysis evolution older than 6 months age. Methods. Several sources were used recollect all...
Background. Nine- and 11-valent pneumococcal conjugate vaccines under development may control pediatric disease in nonindustrialized countries. Because these are expensive, population-based surveillance of children <36 months age was undertaken Santiago, Chile to provide health authorities with reliable data on the burden invasive causative serotypes, including those outpatients high fever. Methods. Automated blood culture machines were introduced into 9 hospitals that admit 85% all...
In Latin America and the Caribbean, routine vaccination of infants against Streptococcus pneumoniae would need substantial investment by governments donor organizations. Policymakers information about projected health benefits, costs, cost-effectiveness when considering these investments. Our aim was to incorporate vaccine, demographic, epidemiologic, cost data into an economic analysis pneumococcal in Caribbean.We previously used a structured literature review develop regional estimates...
Abstract Serogroup W Neisseria meningitidis was the main cause of invasive meningococcal disease in Chile during 2012. The case-fatality rate for this higher than previous years. Genotyping meningococci isolated from case-patients identified hypervirulent lineage W:P1.5,2:ST-11, which contained allele 22 fHbp gene.
Abstract Background Pneumococcal conjugate vaccines (PCVs) are recommended for use in pediatric immunization programs worldwide. Few data available on their effect against mortality. We present a multicountry evaluation of the population-level impact PCVs death due to pneumonia children &lt; 5 years age. Methods obtained national-level mortality between 2000 and 2016 from 10 Latin American Caribbean countries, using standardized protocol. Time series models were used evaluate decline...
Prevalence of hypertension in school age children and its association with obesityBackground: Hypertension is a frequently overlooked problem that an important cardiovascular risk factor.Aim: To determine the prevalence among children.Material Methods: Cross-sectional study 2980 aged 10 ± 2 years (48% females) from schools middle lower class Metropolitan Santiago.Blood pressure (BP) was measured sitting position on three occasions after rest period, using mercury sphygmomanometer appropriate...
Emergence of W135 meningococcal serogroup in
With the upcoming licensure of Outer Membrane Protein-based vaccines against meningococcal disease, data on disease incidence and molecular characteristic circulating N. meningitidis strains in Latin American countries is needed. Chile is, to date, one few region that has performed this type work a comprehensive collection disease-associated from two consecutive years, 2010-2011.A total 119 isolated patients with invasive 2010-2011 were characterized by National Reference Laboratory....
10-valent pneumococcal vaccine (PCV-10) was introduced in 2011 to the National Immunization Program Chile. It administered 4 doses, but 2012 it modified a 3 dose program. This article shows results of Laboratory Surveillance System for Streptococcus pneumoniae isolated invasive disease from 2007 and compares incidence (IPD) by age groups prevaccinal (2007-2010) postvaccinal period (2012).Descriptive study S. surveillance diseases cases confirmed at Reference Institute Public Health Chile...
Laboratory surveillance of Invasive Meningococcal Disease (IMD) is performed by the Institute Public Health Chile. It confirms identification, classifies in serogroups and analyzes genetic profiles Neisseria meningitidis isolates from laboratories throughout country.To show results this 2006 to 2012.A descriptive data analysis confirmed cases IMD serological characterization, susceptibility isolates. The was disaggregated serogroup, age region.From 2012, 486 N. were confirmed. In 2011 a rise...