Katia Abarca
A5054885186- Vector-borne infectious diseases
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- COVID-19 Clinical Research Studies
- Vaccine Coverage and Hesitancy
- Viral gastroenteritis research and epidemiology
- Vector-Borne Animal Diseases
- Bacterial Infections and Vaccines
- Influenza Virus Research Studies
- Immunodeficiency and Autoimmune Disorders
- Bartonella species infections research
- Herpesvirus Infections and Treatments
- Dermatological diseases and infestations
- Rabies epidemiology and control
- Study of Mite Species
- Animal Disease Management and Epidemiology
- Hepatitis Viruses Studies and Epidemiology
- Cytomegalovirus and herpesvirus research
- Streptococcal Infections and Treatments
- Insect symbiosis and bacterial influences
- Toxoplasma gondii Research Studies
- Immune responses and vaccinations
Pontificia Universidad Católica de Chile
2015-2024
Millennium Institute on Immunology and Immunotherapy
2016-2024
Kazan State Medical Academy
2021
Hospital Dipreca
2021
Hospital Luis Calvo Mackenna
2021
Austral University of Chile
2019-2020
Clínica Alemana
2019-2020
Universidad del Desarrollo del Estado de Puebla
2020
Universidad del Desarrollo
2019-2020
Naval Medical Research Command
2019-2020
The genetic analysis of human primary immunodeficiencies has defined the contribution specific cell populations and molecular pathways in host defense against infection. Disseminated infection caused by bacille Calmette-Guérin (BCG) vaccines is an early manifestation immunodeficiencies, such as severe combined immunodeficiency. In many affected persons, cause disseminated BCG disease unexplained.We evaluated infant presenting with features immunodeficiency, including early-onset disease, who...
Scrub typhus is a life-threatening zoonosis caused by Orientia tsutsugamushi organisms that are transmitted the larvae of trombiculid mites. Endemic scrub was originally thought to be confined so called "tsutsugamushi triangle" within Asia-Pacific region. In 2006, however, two individual cases were detected in Middle East and South America, which suggested pathogen present farther afield. Here, we report three autochthonous O. acquired on Chiloé Island southern Chile, suggests existence an...
Homozygosity for the P1104A missense variant of TYK2 Janus kinase is common monogenic etiology primary tuberculosis.
The development of effective vaccines against coronavirus disease 2019 is a global priority. CoronaVac an inactivated severe acute respiratory syndrome 2 (SARS-CoV-2) vaccine with promising safety and immunogenicity profiles. This article reports results obtained for healthy Chilean adults aged ≥18 years in phase 3 clinical trial.Volunteers randomly received doses or placebo, separated by weeks. A total 434 volunteers were enrolled, 397 18-59 37 ≥60 years. Solicited unsolicited adverse...
Abstract Scrub typhus is a potentially fatal rickettsiosis caused by Orientia species intracellular bacteria of the genus Orientia. Although considered to be restricted Asia Pacific region, scrub has recently been discovered in southern Chile. We analyzed gene sequences 16S rRNA (rrs) and 47-kDa (htrA) from 18 patients Sequences were ≥99.7% identical among samples for both amplified genes. Their diversity was 3.1%–3.5% rrs 11.2%–11.8% htrA compared with O. tsusugamushi 3.0% 14.8% Candidatus...
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible of current pandemic ongoing all around world. Since its discovery in 2019, several circulating variants have emerged and some them are associated with increased infections death rate. Despite genetic differences among these variants, vaccines approved for human use shown a good immunogenic protective response against them. In Chile, over 70% vaccinated population immunized CoronaVac, an...
Constant efforts to prevent infections by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are actively carried out around the world. Several vaccines currently approved for emergency use in population, while ongoing studies continue provide information on their safety and effectiveness. CoronaVac is an inactivated SARS-CoV-2 vaccine with a good immunogenicity profile as seen phase 1, 2, 3 clinical trials world, effectiveness of 65.9% symptomatic cases. Although vaccination...
The ongoing COVID-19 pandemic has had a significant impact worldwide, with an incommensurable social and economic burden. rapid development of safe protective vaccines against this disease is global priority. CoronaVac vaccine prototype based on inactivated SARS-CoV-2, which shown promising safety immunogenicity profiles in pre-clinical studies phase 1/2 trials China. To day, four 3 clinical are Brazil, Indonesia, Turkey, Chile. This article reports the results obtained subgroup participants...
CoronaVac is an inactivated SARS-CoV-2 vaccine approved by the World Health Organization (WHO). Previous studies reported increased levels of neutralizing antibodies and specific T cells 2 4 weeks after two doses CoronaVac; these were significantly reduced at 6 to 8 months doses. Here, we report effect a booster dose on anti-SARS-CoV-2 immune response generated against variants concern (VOCs), Delta Omicron, in adults participating phase III clinical trial Chile. Volunteers immunized with...
We report a series of 14 patients from 11 kindreds with recessive partial (RP)-interferon (IFN)-γR1 deficiency. The I87T mutation was found in nine homozygous Chile, Portugal and Poland, the V63G five Canary Islands. Founder effects accounted for recurrence both mutations. most recent common ancestors mutations probably lived 1600 (875-2950) 500 (200-1275) years ago, respectively. two alleles confer phenotypes that are similar but differ terms IFN-γR1 levels residual response to IFN-γ....
Endemic scrub typhus was recently detected on Chiloé Island in southern Chile. We report a series of cases, acquired over wide geographical range continental Chile during 2016-2018, demonstrating that this emerging rickettsial infection is also found the mainland South America.
Hydatidosis is a zoonotic disease of worldwide distribution caused by Echinococcus granulosus. Our study aimed to determine the prevalence human and canine echinococcosis as well associated risk factors in rural area Limarí province northern Chile.A cross-sectional was conducted between August November 2009 using stratified sampling design each five districts province. In selected villages, up 10 households were sampled. Serum fecal samples from an adult family member dog collected...
BackgroundRespiratory syncytial virus (RSV) is responsible for most respiratory tract infections and hospitalizations in infants represents a significant economic burden public health. The development of safe, effective, affordable vaccine priority the WHO.MethodsWe conducted double-blinded, escalating-dose phase 1 clinical trial healthy males aged 18-50 years to evaluate safety, tolerability, immunogenicity recombinant Mycobacterium bovis BCG expressing nucleoprotein RSV (rBCG-N-hRSV). Once...
There is an increasing importance of pet-transmitted infections, some those are considered emerging infections.To determine the species and frequency intestinal parasites in pets with diarrhea (hemorrhagic gastroenteritis excluded).A descriptive retrospective study. Fecal samples from 972 dogs 230 cats consulting two veterinary practices Santiago, between 1996 2003, were studied using Burrows' technique.Protozoa found 64.8% 66.5% cats; helminthes 24% 45.2% cats. The Blastocystis sp. 36%,...
Abstract We conducted a 16S rRNA nested PCR for the genus Ehrlichia and spp. with blood samples from 30 ill dogs in Chile. Phylogenetic analysis was performed by using groESL gene amplification. identified Anaplasma platys as 1 of etiologic agents canine ehrlichiosis.
Latinamerican guidelines of RIICER for diagnosis tick-borne rickettsiosesTick-borne rickettsioses are worldwide infectious diseases that considered emerging and re-emerging.Until recently the only rickettsiosis present in Latin America was Rickettsia rickettsii infection, but to date, with incorporation new tools as PCR sequencing quick cellular close tube cultures (Shell-vial), species has been involved human pathogens.In these guidelines, we offer an update microbiological assays...
Background Scrub typhus is an emerging vector-borne zoonosis, caused by Orientia spp. and transmitted larvae of trombiculid mites, called chiggers. It mainly occurs within a region the Asia-Pacific tsutsugamushi triangle, where rodents are known as most relevant hosts for vector. However, reservoir(s) vector(s) scrub outside unknown. The disease has recently been discovered on considered endemic Chiloé Island in southern Chile. aim present work was to detect determine prevalence chiggers...
Multiple vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been evaluated in clinical trials. However, trials addressing the immune response pediatric population are scarce. The inactivated vaccine CoronaVac has shown to be safe and immunogenic a phase 1/2 trial cohort China. Here, we report interim safety immunogenicity results of 3 for healthy children adolescents Chile. Participants 17 years old received two doses 4-week interval until 31 December 2021....
BackgroundThe Omicron variant has challenged the control of COVID-19 pandemic due to its immuno-evasive properties. The administration a booster dose SARS-CoV-2 vaccine showed positive effects in immunogenicity against SARS-CoV-2, effect that is even enhanced after second booster.MethodsDuring phase-3 clinical trial, we evaluated CoronaVac®, an inactivated administered 6 months first booster, neutralization (n = 87). In parallel, cellular immunity 45) was analyzed stimulated peripheral...
Background: Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infection in young children. Motavizumab an investigational humanized monoclonal antibody for RSV prophylaxis. Methods: A dose-escalation study was conducted followed by assessment safety, tolerability, serum concentrations, and immunogenicity during second consecutive season. In season 1, premature infants aged ≤6 months or children ≤24 with chronic lung disease prematurity received monthly motavizumab...
During November 2010, three ticks were collected from dogs living in the rural area of Arica, northern Chile. Morphological analyses laboratory revealed that they most similar to Amblyomma maculatum Koch and triste Koch. However, because unique metatarsal spurs, neither Chilean specimens could be assigned with certainty A. or triste, based on external morphology. The mitochondrial 16S rRNA gene partial sequences obtained two 99.5% identical Uruguay, 99.0% United States. Through phylogenetic...
Rickettsia felis is an emerging agent considered a human threat; although its natural reservoir and of transmission the cat flea, it has been also found in other vectors. R. identified Chile fleas one specimen Rhipicephalus sanguineus collected Metropolitan Region. The objective this study was to detect presence spp. from dogs two different distant geographical areas Chile.We performed domiciliary sampling urban rural localities country-the Region center northern city Arica. A total 460...
Fleas and ticks are parasites of wild domestic mammals, can be vectors several pathogens. In rural areas, carnivores such as the dog (Canis lupus familiaris L.), may act a "bridge" between natural areas human settlements where ectoparasites used metric link. The aim this study was to identify fleas, ticks, Rickettsia spp., collected from in reserve surrounding Central Chile, using morphological keys molecular analysis. We surveyed 170 households which 107 dogs eight cats were sampled. From...