A5041289271- Mosquito-borne diseases and control
- Travel-related health issues
- Vector-borne infectious diseases
- Malaria Research and Control
- Viral gastroenteritis research and epidemiology
- Viral Infections and Vectors
- Parasites and Host Interactions
- Parasitic Infections and Diagnostics
- Salmonella and Campylobacter epidemiology
- SARS-CoV-2 detection and testing
- Biosensors and Analytical Detection
- Parasite Biology and Host Interactions
- Vector-Borne Animal Diseases
- Bacterial Identification and Susceptibility Testing
- Listeria monocytogenes in Food Safety
- Research on Leishmaniasis Studies
- Long-Term Effects of COVID-19
- Hepatitis Viruses Studies and Epidemiology
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Parasitic infections in humans and animals
- Antifungal resistance and susceptibility
- Trypanosoma species research and implications
- Wikis in Education and Collaboration
- Advanced biosensing and bioanalysis techniques
Clínica Alemana
2015-2024
Universidad del Desarrollo
2015-2024
Charité - Universitätsmedizin Berlin
2003-2024
Humboldt-Universität zu Berlin
2024
Freie Universität Berlin
2024
Naval Medical Research Command
2020
Uniformed Services University of the Health Sciences
2020
Austral University of Chile
2020
Universidad del Desarrollo del Estado de Puebla
2013-2020
Instituto de Investigaciones en Ciencias de la Salud
2020
Scrub typhus is a life-threatening zoonosis caused by Orientia tsutsugamushi organisms that are transmitted the larvae of trombiculid mites. Endemic scrub was originally thought to be confined so called "tsutsugamushi triangle" within Asia-Pacific region. In 2006, however, two individual cases were detected in Middle East and South America, which suggested pathogen present farther afield. Here, we report three autochthonous O. acquired on Chiloé Island southern Chile, suggests existence an...
ABSTRACT The diagnosis of schistosomiasis in individuals from countries where the disease is not endemic challenging, and few data are available on accuracy serological those patients. We evaluated performance eight assays, including four commercial kits, imported areas endemic, six enzyme-linked immunosorbent assays using three different antigens, an indirect hemagglutination assay, immunofluorescent-antibody test. To analyze we used a total 141 serum samples, with 121 derived patients...
Abstract Scrub typhus is a potentially fatal rickettsiosis caused by Orientia species intracellular bacteria of the genus Orientia. Although considered to be restricted Asia Pacific region, scrub has recently been discovered in southern Chile. We analyzed gene sequences 16S rRNA (rrs) and 47-kDa (htrA) from 18 patients Sequences were ≥99.7% identical among samples for both amplified genes. Their diversity was 3.1%–3.5% rrs 11.2%–11.8% htrA compared with O. tsusugamushi 3.0% 14.8% Candidatus...
Traveling to tropical regions is related increased health risks. Travelers— diarrhea the most frequent problem, but range of travel-related diseases also includes potential life-threatening such as malaria. The actual risk European travelers acquiring specific infectious and other hazards in tropics a large extent unknown therefore often adopted from that indigenous population. objective this study was elucidate for diseases, symptoms, accidents population Europeans who travel popular...
Acute diarrhoea is a major cause of childhood morbidity and mortality in sub-Saharan Africa. Its microbiological causes clinico-epidemiological aspects were examined during the dry season 2005/6 Tamale, urban northern Ghana. Stool specimens 243 children with acute 124 control collected. Patients clinically examined, malaria anaemia assessed. Rota-, astro-, noro- adenoviruses identified by (RT-) PCR assays. Intestinal parasites diagnosed microscopy, stool antigen assays PCR, bacteria...
The efficacy and safety of artemether-lumefantrine for the treatment malaria in nonimmune populations are not well defined. In this study, 165 patients from Europe non-malarious areas Colombia with acute, uncomplicated falciparum or mixed infection including P. were treated six-dose regimen artemether-lumefantrine. parasitologic cure rate at 28 days was 96.0% per protocol population (119/124 patients). Median times to parasite clearance fever 41.5 36.8 hours, respectively. No patient had...
The incidence of cutaneous and mucocutaneous Leishmaniasis (CL/MCL) is increasing globally, also in Germany, although the cases are imported still low number. current evidence for different therapies has many limitations due to lack sufficient studies on Leishmania species with differing virulence. So far there no international gold standard optimal management. aim German joint working group Leishmaniasis, formed by societies Tropical Medicine (DTG), Chemotherapy (PEG) Dermatology (DDG), was...
The present study examines the mating and breeding behavior as well genetic differentiation of Culex pipiens biotype Cx. molestus. Firstly, s.l. originating from larval populations various epigeous hypogeous sites in Germany was examined. Autogeny prevailing underground populations, occasionally found semi-open water reservoirs like drains, rarely containers, but never ponds ditches. Secondly, a multilocus enzyme electrophoretic gene flow among seven geographic molestus several European...
Endemic scrub typhus was recently detected on Chiloé Island in southern Chile. We report a series of cases, acquired over wide geographical range continental Chile during 2016-2018, demonstrating that this emerging rickettsial infection is also found the mainland South America.
Cutaneous leishmaniasis (CL) may be emerging among international travellers and migrants. Limited data exist on mucocutaneous (MCL) in travellers. We describe the epidemiology of travel-associated CL MCL immigrants over a 20-year period through descriptive analysis GeoSentinel data.Demographic travel-related returned diagnosed with or at Surveillance Network site between 1 September 1997 31 August 2017 were analysed.A total 955 migrants travel-acquired (n = 916) during study period, whom 10%...
Abstract In the context of Covid-19 pandemic, development and validation rapid easy-to-perform diagnostic methods are high priority. We compared performance four antigen detection tests for SARS-CoV-2 in respiratory samples. Immunochromatographic assays from RapiGEN, Liming bio, Savant, Bioeasy were evaluated using universal transport medium containing naso-oropharyngeal swabs suspected cases. The accuracy was determined comparison to RT-PCR. A total 111 samples included; 80 RT-PCR positive....
Prolonged diarrhoea is common amongst returning travellers and often caused by intestinal protozoa. However, the epidemiology of travel-associated illness protozoal pathogens not well described.
Previous studies have indicated that age is a risk factor for severe falciparum malaria in nonimmune patients. The objectives of this study were to reevaluate previous findings with larger sample and find out how strongly clinical outcomes elderly patients differ from those younger Results adjusted analyses the risks death due malaria, experiencing cerebral or disease general, hospitalization increased significantly each decade life. case-fatality rate was almost 6 times greater among than...
Abstract Viral gastrointestinal infections are among the most important causes of childhood morbidity and mortality, especially in non‐industrialized countries. The objective this study was molecular characterization rotaviruses, noroviruses, adenoviruses, astroviruses, enteroviruses obtained from 367 children Northern Region Ghana. One hundred forty‐two rotavirus‐positive stool samples were examined. frequent type identified G1P[8] occurring 80% cases. Of 27 norovirus positive samples, 5...
Hydatidosis is a zoonotic disease of worldwide distribution caused by Echinococcus granulosus. Our study aimed to determine the prevalence human and canine echinococcosis as well associated risk factors in rural area Limarí province northern Chile.A cross-sectional was conducted between August November 2009 using stratified sampling design each five districts province. In selected villages, up 10 households were sampled. Serum fecal samples from an adult family member dog collected...
Real-Time Reverse-Transcription Polymerase Chain Reaction (RT-PCR) is currently the only recommended diagnostic method for SARS-CoV-2. However, rapid immunoassays SARS-CoV-2 antigen could significantly reduce COVID-19 burden weighing on laboratories around world.We evaluated performance of two fluorescence (FIAs), SOFIA SARS Antigen FIA (Quidel Corporation, San Diego, CA, USA) and STANDARD F Ag (SD Biosensor Inc., Gyeonggi-do, Republic Korea), which use an automated reader. The study used 64...
Campylobacter jejuni and coli are the leading cause of human gastroenteritis in industrialized world an emerging threat developing countries. The incidence campylobacteriosis South America is greatly underestimated, mostly due to lack adequate diagnostic methods. Accordingly, there limited genomic epidemiological data from this region. In present study, we performed a genome-wide analysis genetic diversity, virulence, antimicrobial resistance largest collection clinical C . strains Chile...
Abstract Background Healthcare workers (HCWs) are at high risk of exposure to SARS-CoV-2. Cross-sectional studies have provided variable rates seroprevalence in HCWs. Longitudinal assessments the serological response Covid-19 among HCWs crucial understanding infection and changes antibody titers over time. We aimed investigate factors associated with seroconversion a prospective cohort during peak first wave pandemic. Methods conducted longitudinal study 446 front-line HCWsin tertiary-care...
Key words travel medicine - malaria repellents chemoprophylaxis pediatric travelers pregnant