A5103112339- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Platelet Disorders and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- CRISPR and Genetic Engineering
- Parasites and Host Interactions
- Musculoskeletal pain and rehabilitation
- Research on Leishmaniasis Studies
- Monoclonal and Polyclonal Antibodies Research
- Cardiac Arrest and Resuscitation
- Cell Adhesion Molecules Research
- CAR-T cell therapy research
- Mesenchymal stem cell research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- SARS-CoV-2 detection and testing
- Dermatological diseases and infestations
- Hematopoietic Stem Cell Transplantation
- Viral Infections and Immunology Research
- Mechanical Circulatory Support Devices
- Viral gastroenteritis research and epidemiology
University of Utah
2023-2024
The Ohio State University Wexner Medical Center
2022
Yale Cancer Center
2013
Yale University
2013
Cutaneous leishmaniasis (CL) may be emerging among international travellers and migrants. Limited data exist on mucocutaneous (MCL) in travellers. We describe the epidemiology of travel-associated CL MCL immigrants over a 20-year period through descriptive analysis GeoSentinel data.Demographic travel-related returned diagnosed with or at Surveillance Network site between 1 September 1997 31 August 2017 were analysed.A total 955 migrants travel-acquired (n = 916) during study period, whom 10%...
Deep mutational scanning experiments aid in the surveillance and forecasting of viral evolution by providing prospective measurements effects on traits, but epistatic shifts impacts mutations can hinder when were made outdated strain backgrounds. Here, we report impact all single amino acid ACE2-binding affinity protein folding expression SARS-CoV-2 Omicron BA.2.86 spike receptor-binding domain (RBD). As with other variants, find a plastic evolvable basis for receptor binding, many at ACE2...
The recurring spillover of pathogenic coronaviruses and demonstrated capacity sarbecoviruses, such SARS-CoV-2, to rapidly evolve in humans underscores the need better understand immune responses this virus family. For purpose, we characterized functional breadth potency antibodies targeting receptor binding domain (RBD) spike glycoprotein that exhibited cross-reactivity against SARS-CoV-2 variants, SARS-CoV-1 sarbecoviruses from diverse clades animal origins with potential. One neutralizing...
Porcine delta-coronavirus (PDCoV) spillovers were recently detected in febrile children, underscoring the recurrent zoonoses of divergent CoVs. To date, no vaccines or specific therapeutics are approved for use humans against PDCoV. prepare possible future PDCoV epidemics, we isolated spike (S)-directed monoclonal antibodies (mAbs) from humanized mice and found that two, designated PD33 PD41, broadly neutralized a panel variants. Cryoelectron microscopy (cryo-EM) structures PD41 complex with...
Extracorporeal photopheresis (ECP) is frequently utilized in the treatment of steroid-refractory acute and chronic graft-versus-host disease (GVHD). Although mechanism action not fully understood, it has been postulated that its therapeutic effect immunologic tolerance linked to associated apoptosis treated cells. Despite significant advances allogeneic hematopoietic stem cell transplantation (HSCT), prophylaxis GVHD remain a challenge major limitation with this therapy. Use ECP valuable...