Nicholas J. Beeching
A5045561324- Viral gastroenteritis research and epidemiology
- Travel-related health issues
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Hepatitis Viruses Studies and Epidemiology
- Parasitic Infections and Diagnostics
- Viral Infections and Outbreaks Research
- Parasites and Host Interactions
- Amoebic Infections and Treatments
- HIV/AIDS Research and Interventions
- Tuberculosis Research and Epidemiology
- Hepatitis C virus research
- Pneumocystis jirovecii pneumonia detection and treatment
- Hepatitis B Virus Studies
- HIV/AIDS drug development and treatment
- Clostridium difficile and Clostridium perfringens research
- Salmonella and Campylobacter epidemiology
- HIV Research and Treatment
- HIV, Drug Use, Sexual Risk
- Malaria Research and Control
- Zoonotic diseases and public health
- Pneumonia and Respiratory Infections
- Brucella: diagnosis, epidemiology, treatment
- Infectious Diseases and Tuberculosis
- Streptococcal Infections and Treatments
Liverpool School of Tropical Medicine
2016-2025
University College London
2003-2024
National University of Singapore
2024
National University Health System
2024
MRC Clinical Trials Unit at UCL
2024
University of Liverpool
2014-2023
National Institute for Health Research
2011-2023
Health Protection Research Unit in Emerging and Zoonotic Infections at University of Liverpool
1991-2023
Aintree University Hospitals NHS Foundation Trust
2021-2023
Royal Liverpool University Hospital
2012-2021
Cases of human monkeypox are rarely seen outside west and central Africa. There few data regarding viral kinetics or the duration shedding no licensed treatments. Two oral drugs, brincidofovir tecovirimat, have been approved for treatment smallpox demonstrated efficacy against in animals. Our aim was to describe longitudinal clinical course a high-income setting, coupled with dynamics, any adverse events related novel antiviral therapies.
Bacterial meningitis and meningococcal sepsis are rare conditions with high case fatality rates. Early recognition prompt treatment saves lives. In 1999 the British Infection Society produced a consensus statement for management of immunocompetent adults sepsis.Since there have been many changes. We therefore set out to produce revised guidelines which provide standardised evidence-based approach acute community acquired in adults.A working party consisting infectious diseases physicians,...
Rapid near patient testing for both current and past infections is urgently required "Test, test, test" the key to controlling spread of SARS-CoV-2 its clinical manifestation, covid-19, according World Health Organisation.1However, three months after notification novel coronavirus infection in China, there inadequate access appropriate diagnostic tests globally confusion among healthcare professionals public about prioritisation interpretation results.The virus by respiratory route,...
We report a case-control study of sporadic cryptosporidiosis with genotyping isolates from case-patients. A postal questionnaire was completed by 427 patients and controls. obtained data on 191 patients; 115 were Cryptosporidium hominis, 76 C. parvum. When all cases analyzed, three variables strongly associated illness: travel outside the United Kingdom, contact another person diarrhea, touching cattle. Eating ice cream eating raw vegetables both negatively illness. Helping child <5 years...
BackgroundStaphylococcus aureus bacteraemia is a common cause of severe community-acquired and hospital-acquired infection worldwide. We tested the hypothesis that adjunctive rifampicin would reduce bacteriologically confirmed treatment failure or disease recurrence, death, by enhancing early S killing, sterilising infected foci blood faster, reducing risks dissemination metastatic infection.MethodsIn this multicentre, randomised, double-blind, placebo-controlled trial, adults (≥18 years)...
BackgroundViral meningitis is increasingly recognised, but little known about the frequency with which it occurs, or causes and outcomes in UK. We aimed to determine incidence, causes, sequelae UK adults improve management of patients assist health service planning.MethodsWe did a multicentre prospective observational cohort study suspected at 42 hospitals across England. Nested within this study, National Health Service (NHS) northwest region (now part NHS England North), was an...
ABSTRACT An 840-bp fragment of the 18S rRNA gene was used to identify Cryptosporidium spp. recovered from human immunodeficiency virus (HIV)-infected and -uninfected patients Kenya, Malawi, Brazil, United Kingdom, Vietnam. Initial identification by Ziehl-Neelsen acid-fast staining. Confirmation nested PCR, targeting most polymorphic region gene. Genotyping restriction endonuclease digestion PCR product followed nucleotide sequencing. Among 63 isolates analyzed, four genotypes were...
<h3>Introduction</h3> Bacterial meningitis is a medical emergency, the outcome of which improved by prompt antibiotic treatment. For patients with suspected and no features severe disease, British Infection Society recommends immediate lumbar puncture (LP) before antibiotics, to maximise chance positive cerebrospinal (CSF) culture. In such patients, CT scanning LP not needed. <h3>Methods</h3> The case notes adults admitted large district general hospital over 3 years were reviewed. Patients...
Abstract Chikungunya virus (CHIKV) is a mosquito-borne alphavirus best known for causing fever, rash, arthralgia, and occasional neurologic disease. By using real-time reverse transcription–PCR, we detected CHIKV in plasma samples of 8 (14%) 58 children with suspected central nervous system infection Bellary, India. was also the cerebrospinal fluid 3 children.
We assessed the risk of clinically significant drug interactions in patients receiving antiretrovirals, and their recognition by physicians. Clinically were recorded 27% 159 patients, with 15% potentially lowering antiretroviral concentrations. Risk was significantly related to receipt protease inhibitors. Only 36% correctly identified
Abstract Background Estimates of travel-related illness have focused predominantly on populations from highly developed countries visiting low- or middle-income countries, yet travel to and within high-income is very frequent. Despite being a top international tourist destination, few sources describe the spectrum infectious diseases acquired among travellers USA. Methods We performed descriptive analysis summarizing demographic characteristics, clinical diagnoses non-US-resident seen during...
Common problems in ill returned travelers to Brazil are dermatologic conditions, diarrhea, and febrile illnesses, especially dengue. Knowledge of potential risks can help clinicians advise attending large events care for those who become ill. Background. will host the 2014 FIFA World Cup 2016 Olympic Paralympic Games, that expected attract hundreds thousands international travelers. Travelers encounter locally endemic infections as well mass event–specific risks. Methods. We describe 1586...
Healthcare-related transmission of Crimean-Congo haemorrhagic fever (CCHF) is a well-recognized hazard. We report multicentre retrospective cross-sectional study undertaken in Turkey 2014 nine hospitals, regional reference centres for CCHF, covering the years 2002 to inclusive. Data were systematically extracted from charts all personnel with reported health care injury/accident related CCHF. Blood samples tested CCHF IgM/IgG by enzyme-linked immunosorbent assay and/or viral nucleic acid...