A5033557169- Antimicrobial Resistance in Staphylococcus
- Amoebic Infections and Treatments
- Bacterial Identification and Susceptibility Testing
- Infective Endocarditis Diagnosis and Management
- Streptococcal Infections and Treatments
- Parasitic Infections and Diagnostics
- Antibiotics Pharmacokinetics and Efficacy
- Drug-Induced Adverse Reactions
- Pancreatitis Pathology and Treatment
- Orthopedic Infections and Treatments
- Antifungal resistance and susceptibility
- Antibiotic Resistance in Bacteria
- Parasites and Host Interactions
- Diagnosis and treatment of tuberculosis
- Nosocomial Infections in ICU
- Gout, Hyperuricemia, Uric Acid
- Clostridium difficile and Clostridium perfringens research
- Trypanosoma species research and implications
- Brucella: diagnosis, epidemiology, treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Fungal Infections and Studies
- Historical Medical Research and Treatments
- Bacterial biofilms and quorum sensing
- Liver Disease Diagnosis and Treatment
- Synthesis and Biological Evaluation
Dartford And Gravesham NHS Trust
2010-2019
Darent Valley Hospital
2008-2019
University College London
1993-1998
Whittington Hospital
1994-1998
Royal London Hospital
1995-1997
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
1996
Hospital for Tropical Diseases
1996
London School of Hygiene & Tropical Medicine
1991-1995
Public Health Laboratory
1995
University College Hospital
1993
BackgroundStaphylococcus aureus bacteraemia is a common cause of severe community-acquired and hospital-acquired infection worldwide. We tested the hypothesis that adjunctive rifampicin would reduce bacteriologically confirmed treatment failure or disease recurrence, death, by enhancing early S killing, sterilising infected foci blood faster, reducing risks dissemination metastatic infection.MethodsIn this multicentre, randomised, double-blind, placebo-controlled trial, adults (≥18 years)...
AIMS--To assess the reliability of detection erythrophagocytic amoebic trophozoites in stool samples diagnosis dysentery associated with invasive Entamoeba histolytica. METHODS--Amoebic culture was carried out on single collected from patients Mexico, Colombia, and Bangladesh. The stools had been examined by light microscopy. Amoebic diagnosed when E histolytica were observed a case bloody diarrhoea. isolates characterised isoenzyme electrophoresis results correlated microscopical findings...
To describe the patient populations and infections being treated with daptomycin, as well efficacy safety outcomes. Data from European Cubicin Outcomes Registry Experience (EU-CORESM), retrospectively collected at 118 institutions between January 2006 August 2008, were analysed. Daptomycin treatment was documented in 1127 patients diverse infections, including complicated skin soft tissue (33%), bacteraemia (22%), endocarditis (12%) osteomyelitis (6%). It used empirically, before...
Pooled data from two large registries, Cubicin® Outcomes Registry and Experience (CORE; USA) European (EU-CORE; Europe, Latin America, Asia), were analyzed to determine the characteristics clinical outcomes of daptomycin therapy in patients with Gram-positive infections across wide geographical regions. Patients receiving at least one dose between 2004 2012 for treatment included. Clinical success was defined as an outcome 'cured' or 'improved'. Post-treatment follow-up collected a subset...
A retrospective analysis of data from patients receiving daptomycin as outpatient parenteral antimicrobial therapy (OPAT) within the European Cubicin Outcomes Registry and Experience (EU-CORE(SM)) was performed. Of 4592 enrolled in 15 countries, 550 (12%) received OPAT. these, 149 (27%) without hospital admission, 84% had significant underlying diseases 44% were ≥65 years age. Most frequently treated infections complicated skin soft-tissue (28%), osteomyelitis (17%), foreign body/prosthetic...
An invasive strain-specific monoclonal antibody against Entamoeba histolytica has been used in a capture enzyme-linked immunosorbent assay (ELISA) for the detection of E. fecal antigen clinical specimens and diagnosis amebic dysentery patients from Bangladesh. The ELISA (FAC-ELISA) did not cross-react with other parasite species or noninvasive present those experimentally seeded stools. limit crude diluted phosphate-buffered saline stools was 0.58 3.9 micrograms/ml, respectively, which is...
The aim of this study was to evaluate the clinical outcomes and safety daptomycin therapy in patients with serious Gram-positive infections.Patients were enrolled European Cubicin(®) Outcomes Registry Experience (EU-CORE(SM)), a non-interventional, multicenter, observational registry. real-world data collected across 18 countries (Europe, Latin America, Asia) for who had received at least one dose between January 2006 April 2012. Two-year follow-up until 2014 endocarditis,...
Approximately 10% of the world population is infected with Entamoeba histolytica, but only carriers develop symptomatic amebiasis. This discrepancy could be explained by genotypic differences between morphologically indistinguishable invasive and noninvasive strains E. histolytica currently identified zymodeme analysis, a technique that unsuitable for routine diagnostic laboratories. Here we report production monoclonal antibody against its use in an immunofluorescence assay to identify...
IntroductionIn 2002, the Surviving Sepsis Campaign defi ned a strategy that aimed to reduce high mortality due sepsis.One point of this was recommendation recognize sepsis is frequent cause death and economic costs in pediatric intensive care unit.Knowledge disease fi rst step impact it.There are few studies on epidemiology world none Colombia.Hypothesis The epidemiological features Colombian children diff erent from other countries.Methods We constructed website where 14 units across...
Background Staphylococcus aureus bacteraemia is a common and frequently fatal infection. Adjunctive rifampicin may enhance early S. killing, sterilise infected foci blood faster, thereby reduce the risk of dissemination, metastatic infection death. Objectives To determine whether or not adjunctive reduces bacteriological (microbiologically confirmed) failure/recurrence death through 12 weeks from randomisation. Secondary objectives included evaluating impact on all-cause mortality,...
The objective of this analysis was to describe in real-life settings the clinical outcomes and safety associated with daptomycin treatment a cohort patients complicated skin soft tissues infection (cSSTI).All cSSTI who had received at least one dose between January 2006 April 2012 were identified from non-interventional, multicenter, retrospective registry (European Cubicin(®) Outcome Registry Experience; EU-CORE(SM)).Of 6075 included EU-CORE registry, 1927 (31.7%) diagnosed (male, 63.8%;...
The objective was to study the lipoprotein levels in primary hyperuricaemic patients and analyse their renal management of urates order check for some potential influence altered lipid on excretion by this type patient. Overall 115 male individuals were studied five groups, namely: 30 (group I); 27 hyperuricaemic–hypercholesterolaemic II); nine hyperuricaemic–hypertriglyceridaemic III) 33 hyperuricaemic-mixed hyperlipidaemic IV); 16 normouricaemic–normolipidaemic subjects C). All subjected...
From 1st January until 31st December 2007, there were 31 MRSA bacteraemias at our NHS Trust. 22 defined as HAI. It was discovered that the source of in 12 (54%) patients due to PIVD (Peripheral Intravascular Devices).