M. Estée Török
A5016710242- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- SARS-CoV-2 and COVID-19 Research
- Antibiotic Resistance in Bacteria
- Tuberculosis Research and Epidemiology
- Infectious Diseases and Tuberculosis
- COVID-19 Clinical Research Studies
- Streptococcal Infections and Treatments
- SARS-CoV-2 detection and testing
- Pneumocystis jirovecii pneumonia detection and treatment
- Mycobacterium research and diagnosis
- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Nosocomial Infections in ICU
- COVID-19 epidemiological studies
- Infective Endocarditis Diagnosis and Management
- Bacterial biofilms and quorum sensing
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Use and Resistance
- Respiratory viral infections research
- Clostridium difficile and Clostridium perfringens research
- Genomics and Phylogenetic Studies
- Hepatitis B Virus Studies
- Bacteriophages and microbial interactions
- Animal Virus Infections Studies
Cambridge University Hospitals NHS Foundation Trust
2015-2024
University of Cambridge
2015-2024
UK Health Security Agency
2022-2023
Imperial College London
1999-2022
Quadram Institute
2022
Public Health England
2013-2021
National Health Service
2011-2021
University of Cologne
2021
University College London
2021
Addenbrooke's Hospital
2010-2020
SummaryBackgroundA safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of COVID-19 pandemic. We evaluated safety efficacy ChAdOx1 nCoV-19 in a pooled interim analysis four trials.MethodsThis includes data from ongoing blinded, randomised, controlled trials done across UK, Brazil, South Africa. Participants aged 18 years older were randomly assigned (1:1) or (meningococcal group A,...
The ChAdOx1 nCoV-19 (AZD1222) vaccine has been approved for emergency use by the UK regulatory authority, Medicines and Healthcare products Regulatory Agency, with a regimen of two standard doses given an interval 4-12 weeks. planned roll-out in will involve vaccinating people high-risk categories their first dose immediately, delivering second 12 weeks later. Here, we provide both further prespecified pooled analysis trials exploratory analyses impact on immunogenicity efficacy extending...
The emergence of meticillin-resistant Staphylococcus aureus (MRSA) that can persist in the community and replace existing hospital-adapted lineages MRSA means it is necessary to understand transmission dynamics terms hospitals as one entity. We assessed use whole-genome sequencing enhance detection between these settings.We studied a putative outbreak on special care baby unit (SCBU) at National Health Service Foundation Trust Cambridge, UK. used validate expand findings from an...
Significant differences exist in the availability of healthcare worker (HCW) SARS-CoV-2 testing between countries, and existing programmes focus on screening symptomatic rather than asymptomatic staff. Over a 3 week period (April 2020), 1032 HCWs were screened for large UK teaching hospital. Symptomatic staff household contacts additionally tested. Real-time RT-PCR was used to detect viral RNA from throat+nose self-swab. 3% group tested positive SARS-CoV-2. 17/30 (57%) truly...
The factors that govern the development of tuberculosis disease are incompletely understood. We hypothesized some strains Mycobacterium (M. tuberculosis) more capable causing disseminated than others and may be associated with polymorphisms in host genes responsible for innate immune response to infection. compared bacterial genotype 187 Vietnamese adults tuberculous meningitis (TBM) 237 uncomplicated pulmonary tuberculosis. cases was also 392 cord blood controls from same population....
We report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike ΔH69/V70 in multiple independent lineages, often occurring after acquisition of receptor binding motif replacements such as N439K and Y453F, known to increase affinity the ACE2 confer antibody escape. In vitro, we show that, although itself is not an evasion mechanism, it increases infectivity associated with enhanced incorporation cleaved into virions. able partially rescue proteins that have acquired Y453F escape...
The burden and influence of health-care associated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is unknown. We aimed to examine the use rapid SARS-CoV-2 sequencing combined with detailed epidemiological analysis investigate inform infection control measures.
Background. The optimal time to initiate antiretroviral therapy (ART) in human immunodeficiency virus (HIV)–associated tuberculous meningitis is unknown.
Monitoring the spread of SARS-CoV-2 and reconstructing transmission chains has become a major public health focus for many governments around world. The modest mutation rate rapid prevents reconstruction from consensus genome sequences, but within-host genetic diversity could theoretically help identify close contacts. Here we describe patterns in 1181 samples sequenced to high depth duplicate. 95.1% show mutations at detectable allele frequencies. Analyses mutational spectra revealed strong...
It is uncertain whether all adults with bacterial meningitis benefit from treatment adjunctive dexamethasone.We conducted a randomized, double-blind, placebo-controlled trial of dexamethasone in 435 patients over the age 14 years who had suspected meningitis. The goal was to determine reduced risk death at 1 month and or disability 6 months.A total 217 were assigned group, 218 placebo group. Bacterial confirmed 300 (69.0%), probable diagnosed 123 (28.3%), an alternative diagnosis made 12...
<h3>Importance</h3> The latest generation of benchtop DNA sequencing platforms can provide an accurate whole-genome sequence (WGS) for a broad range bacteria in less than day. These could be used to more effectively contain the spread multidrug-resistant pathogens. <h3>Objective</h3> To compare WGS with standard clinical microbiology practice investigation nosocomial outbreaks caused by bacteria, identification genetic determinants antimicrobial resistance, and typing other clinically...
We used large sequence polymorphisms to determine the genotypes of 397 isolates Mycobacterium tuberculosis from human immunodeficiency virus-uninfected Vietnamese adults with pulmonary (n = 235) or meningeal 162) tuberculosis. compared pretreatment radiographic appearances and presentation, response treatment, outcome tuberculous meningitis between genotypes. Multivariate analysis identified variables independently associated genotype outcome. A higher proportion caused by Euro-American had...
BackgroundStaphylococcus aureus bacteraemia is a common cause of severe community-acquired and hospital-acquired infection worldwide. We tested the hypothesis that adjunctive rifampicin would reduce bacteriologically confirmed treatment failure or disease recurrence, death, by enhancing early S killing, sterilising infected foci blood faster, reducing risks dissemination metastatic infection.MethodsIn this multicentre, randomised, double-blind, placebo-controlled trial, adults (≥18 years)...
Tuberculous meningitis (TBM) is the most lethal form of tuberculosis, and new treatments that improve outcomes are required. We randomly assigned adults with TBM to treatment standard antituberculosis alone or in combination ciprofloxacin (750 mg/12 h), levofloxacin (500 gatifloxacin (400 mg/24 h) for first 60 days therapy. Fluoroquinolone concentrations were measured plasma cerebrospinal fluid (CSF) specimens taken at predetermined, times throughout treatment. aimed describe...
Abstract The response to the coronavirus disease 2019 (COVID-19) pandemic has been hampered by lack of an effective severe acute respiratory syndrome 2 (SARS-CoV-2) antiviral therapy. Here we report use remdesivir in a patient with COVID-19 and prototypic genetic antibody deficiency X-linked agammaglobulinaemia (XLA). Despite evidence complement activation robust T cell response, developed persistent SARS-CoV-2 pneumonitis, without progressing multi-organ involvement. This unusual clinical...
Longitudinal genomic and epidemiological surveillance of methicillin-resistant Staphylococcus aureus in the UK reveals extensive transmission hospitals community.