A5040374998- Salmonella and Campylobacter epidemiology
- Viral gastroenteritis research and epidemiology
- Antibiotic Resistance in Bacteria
- Vibrio bacteria research studies
- Antibiotics Pharmacokinetics and Efficacy
- Escherichia coli research studies
- Malaria Research and Control
- Mosquito-borne diseases and control
- Immune Response and Inflammation
- Electrochemical sensors and biosensors
- Electrochemical Analysis and Applications
- Viral Infections and Immunology Research
- Analytical Chemistry and Sensors
- Gas Sensing Nanomaterials and Sensors
- Animal Virus Infections Studies
- Influenza Virus Research Studies
- Drug-Induced Hepatotoxicity and Protection
- Acoustic Wave Resonator Technologies
- Hepatitis Viruses Studies and Epidemiology
- Data-Driven Disease Surveillance
- Bacteriophages and microbial interactions
- Advanced biosensing and bioanalysis techniques
- COVID-19 epidemiological studies
- Venomous Animal Envenomation and Studies
- Leprosy Research and Treatment
Hanoi University of Industry
2022-2025
University Of Transport Technology
2020-2024
Hospital for Tropical Diseases
2011-2024
University of Pecs
2024
Oxford University Clinical Research Unit
1998-2023
Hanoi University of Science and Technology
2020-2023
Le Quy Don Technical University
2017-2023
Vinh University
2021
Hanoi University of Pharmacy
2019
Pham Ngoc Thach University of Medicine
2017-2018
Artemisinin (qinghaosu) and its derivatives are rapidly effective antimalarial drugs derived from a Chinese plant. Preliminary studies suggest that these may be more than quinine in the treatment of severe malaria. We studied artemether Vietnam, where Plasmodium falciparum has reduced sensitivity to quinine.
Background. The optimal time to initiate antiretroviral therapy (ART) in human immunodeficiency virus (HIV)–associated tuberculous meningitis is unknown.
Nalidixic acid-resistant Salmonella typhi (NARST) was first isolated in Viet Nam 1993. Analysis of the quinolone resistance-determining region gyrA 20 NARST isolates by polymerase chain reaction and single-stranded conformational polymorphism yielded two novel patterns: pattern II corresponding to a point mutation at nucleotide 87 Asp → Gly (n = 17), III 83 Ser Phe 3). In trials short-course ofloxacin therapy for uncomplicated typhoid, 117 (78%) 150 patients were infected with...
This study describes the pattern and extent of drug resistance in 1,774 strains Salmonella enterica serovar Typhi isolated across Asia between 1993 2005 characterizes molecular mechanisms underlying reduced susceptibilities to fluoroquinolones these strains. For 1,393 collected southern Vietnam, proportion multidrug has remained high since (50% 2004) there was a dramatic increase nalidixic acid (4%) (97%). In cross-sectional sample 381 from 8 Asian countries, Bangladesh, China, India,...
ABSTRACT Enteric fever is the only bacterial infection of humans for which bone marrow examination routinely recommended. A prospective study concentrations bacteria in and their relationship to clinical features was conducted with 120 Vietnamese patients suspected enteric fever, whom 89 had confirmed typhoid fever. Ninety-three percent Salmonella enterica serovar Typhi samples isolated were resistant ampicillin, chloramphenicol, co-trimoxazole. For 81 uncomplicated satisfactory aspirates,...
Since 1988 in this referral center for severe cases of malaria South Vietnam, a specialist team has managed malaria-associated renal failure (MARF) with peritoneal dialysis, and the mortality rate MARF fallen from 75% (78 104) to 26% (27 (P < .0002). Sixty-four patients (of whom 12 died) were compared 66 whose serum creatinine levels remained <250 µmol/L (six died). had clinical biochemical features acute tubular necrosis was significantly associated liver dysfunction .05). A fatal outcome...
Significance Shigella sonnei is a globally emerging agent of bacterial dysentery. Here, we use genomics to examine the microevolution S. in Vietnam. We show that was introduced into Vietnam early 1980s, where it continued evolve, spreading geographically establish localized founder populations. The population Ho Chi Minh City has undergone several clonal replacement events, during which small number microevolutionary changes have risen dominance. These changes, induced by horizontal gene...
ABSTRACT The diagnostic value of an acute-phase single-tube Widal test for suspected typhoid fever was evaluated with 2,000 Vietnamese patients admitted to infectious disease referral hospital between 1993 and 1998. Test had a blood culture positive Salmonella typhi ( n = 1,400) or paratyphi A 45). Control febrile illness which another cause confirmed (malaria [ 103], dengue 76], bacteremia due microorganism 156] tetanus 265). An O-agglutinin titer ≥100 found in 18% the controls 7% patients....
ABSTRACT Currently, the laboratory diagnosis of typhoid fever is dependent upon either isolation Salmonella enterica subsp. serotype Typhi from a clinical sample or detection raised titers agglutinating serum antibodies against lipopolysaccharide (LPS) (O) flagellum (H) antigens (the Widal test). In this study, antibody responses to LPS and were investigated with individuals region Vietnam in which endemic, their usefulness for was evaluated. The both highly variable among infected Typhi,...
Abstract Background Shigellosis remains considerable public health problem in some developing countries. The nature of Shigellae suggests that they are highly adaptable when placed under selective pressure a human population. This is demonstrated by variation and fluctuations serotypes antimicrobial resistance profile organisms circulating differing setting endemic locations. Antimicrobial the genus Shigella constant threat, with reports Asia being resistant to multiple antimicrobials new...
BackgroundDrug resistant typhoid fever is a major clinical problem globally. Many of the first line antibiotics, including older generation fluoroquinolones, ciprofloxacin and ofloxacin, are failing.ObjectivesWe performed randomised controlled trial to compare efficacy safety gatifloxacin (10 mg/kg/day) versus azithromycin (20 as once daily oral dose for 7 days treatment uncomplicated in children adults Vietnam.MethodsAn open-label multi-centre with pre-specified per protocol analysis...
We performed a prospective multicenter study to address the lack of data on etiology, clinical and demographic features hospitalized pediatric diarrhea in Ho Chi Minh City (HCMC), Vietnam. Over 2,000 (1,419 symptomatic 609 non-diarrheal control) children were enrolled three hospitals over 1-year period 2009–2010. Aiming detect panel pathogens, we identified known diarrheal pathogen stool samples from 1,067/1,419 (75.2%) with 81/609 (13.3%) without diarrhea. Rotavirus predominated (664/1,419;...
The effect of crystallinity, phase ratio, and heterojunction formation on the FZD sensing performance ZnO/ZnFe 2 O 4 nanocomposite-based electrochemical sensors was investigated.
Journal Article Comparison of artemisinin suppositories with intravenous artesunate and quinine in the treatment cerebral malaria Get access Tran Tinh Hien, Hien ∗ 1Intensive Care Unit, Centre for Tropical Diseases, Ho Chi Minh City, Vietnam ∗Address correspondence: Cho Quan Hospital, 190 Ben Ham Tu, Q5, Vietnam. Search other works by this author on: Oxford Academic PubMed Google Scholar Keith Arnold, Arnold 2Roche Asian Research Foundation, Hong Kong Ha Vinh, Vinh Bui Cuong, Cuong Nguyen...
Background Infection with Salmonella enterica serovar Typhi (S. Typhi) reduced susceptibility to fluoroquinolones has been associated fluoroquinolone treatment failure. We studied the relationship between ofloxacin response and minimum inhibitory concentration (MIC) of infecting isolate. Individual patient data from seven randomised controlled trials antimicrobial in enteric fever conducted Vietnam which was used at least one arms studied. Data 540 patients analysed identify an MIC organism...
ABSTRACT Azithromycin is an effective treatment for uncomplicated infections with Salmonella enterica serovar Typhi and Paratyphi A (enteric fever), but there are no clinically validated MIC disk zone size interpretative guidelines. We studied individual patient data from three randomized controlled trials (RCTs) of antimicrobial in enteric fever Vietnam, azithromycin used one arm, to determine the relationship between response infecting isolate. additionally compared susceptibility sizes...
The recent advancement in designing novel spinel nanostructures has opened virtually infinite possibilities for the development of high-performance electrochemical sensors to detect target species. electrocatalytic activity structures can be enhanced by tuning cation distribution; however, role distribution at tetrahedral ions on sensing responses rarely been considered. Herein, effect sites (Td) nanostructure ZnCo2O4 performance toward carbaryl (CBR) was first investigated. nanoflake...
Dengue shock syndrome (DSS) is a potentially lethal complication of dengue virus infection associated with hypotension and leakage plasma water into the extravascular space. To determine whether underlying pathophysiology DSS distinct from that in milder forms disease, we assessed microvascular permeability, by use strain gauge plethysmography, Vietnamese children (n=19), or hemorrhagic fever (DHF) without (n=16), healthy control (n=15). At admission after fluid resuscitation, mean...
We prospectively studied 50 Vietnamese patients with blackwater fever (BWF). All had and hemoglobinuria, 40 (80%) were jaundiced, 25 (50%) hepatomegaly, 15 (34%) splenomegaly, 9 (18%) hepatosplenomegaly. Twenty-one (42%) impaired renal function, creatinine clearances of < mL/min/m2; however, only four (8%) developed oliguric failure, three (6%) whom required dialysis. Forty-four (88%) anemia, which was severe (hematocrit, 20% in 32 (64%). One patient died, representing a death rate for this...
An open randomized comparison of 2 days (Ofx2) versus 3 (Ofx3) oral ofloxacin treatment (15 mg/kg/day) was conducted with Vietnamese children between 1 and 15 years age suspected typhoid fever. Of 108 enrolled, 100 were blood culture positive for Salmonella typhi, 86% the isolates multidrug resistant. There no significant adverse effects. The therapeutic responses similar in both groups, mean (+/- standard deviation) fever clearances 107 +/- 60 h Ofx3 group 64 Ofx2 (P > 0.2). six...
Background Plasmid mediated antimicrobial resistance in the Enterobacteriaceae is a global problem. The rise of CTX-M class extended spectrum beta lactamases (ESBLs) has been well documented industrialized countries. Vietnam representative typical transitional middle income country where infectious diseases combined with spread drug shifting and bringing new healthcare challenges. Methodology We collected hospital admission data from pediatric population attending for tropical Ho Chi Minh...
Typhoid fever is a systemic infection caused by the bacterium Salmonella enterica serovar Typhi. Age, sex, prolonged duration of illness, and with an antimicrobial resistant organism have been proposed risk factors for development severe disease or fatality in typhoid fever. We analysed clinical data from 581 patients consecutively admitted culture confirmed to two hospitals Vietnam during periods 1993–1995 1997–1999. These spanned change resistance phenotypes infecting organisms i.e. fully...