Paul N. Newton
A5013453998- Mosquito-borne diseases and control
- Malaria Research and Control
- Viral Infections and Vectors
- Vector-borne infectious diseases
- Pharmaceutical Quality and Counterfeiting
- Pharmaceutical Economics and Policy
- Computational Drug Discovery Methods
- Antibiotic Resistance in Bacteria
- Leptospirosis research and findings
- Burkholderia infections and melioidosis
- Antibiotic Use and Resistance
- Pneumonia and Respiratory Infections
- Salmonella and Campylobacter epidemiology
- Identification and Quantification in Food
- Drug-Induced Hepatotoxicity and Protection
- Respiratory viral infections research
- Bacterial Identification and Susceptibility Testing
- Vibrio bacteria research studies
- Global Maternal and Child Health
- Chemical Looping and Thermochemical Processes
- Influenza Virus Research Studies
- Zoonotic diseases and public health
- Viral gastroenteritis research and epidemiology
- Streptococcal Infections and Treatments
- Trypanosoma species research and implications
University of Oxford
2016-2025
Mahidol University
2015-2025
Mahidol Oxford Tropical Medicine Research Unit
2015-2025
Infectious Diseases Data Observatory
2016-2025
Mahosot Hospital
2015-2024
Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit
2015-2024
Wellcome Trust
2015-2024
London School of Hygiene & Tropical Medicine
2015-2024
Churchill Hospital
2013-2022
University of London
2018-2022
Artemisinin resistance in Plasmodium falciparum has emerged Southeast Asia and now poses a threat to the control elimination of malaria. Mapping geographic extent is essential for planning containment strategies.Between May 2011 April 2013, we enrolled 1241 adults children with acute, uncomplicated malaria an open-label trial at 15 sites 10 countries (7 3 Africa). Patients received artesunate, administered orally daily dose either 2 mg per kilogram body weight day or 4 kilogram, days,...
Klebsiella pneumoniae is now recognized as an urgent threat to human health because of the emergence multidrug-resistant strains associated with hospital outbreaks and hypervirulent severe community-acquired infections. K. ubiquitous in environment can colonize infect both plants animals. However, little known about population structure pneumoniae, so it difficult recognize or understand clinically important clones within this highly genetically diverse species. Here we present a detailed...
In falciparum malaria sequestration of erythrocytes containing mature forms Plasmodium in the microvasculature vital organs is central to pathology, but quantitation this hidden sequestered parasite load vivo has not previously been possible. The peripheral blood count measures only circulating, relatively non-pathogenic numbers. P. releases a specific histidine-rich protein (PfHRP2) into plasma. Quantitative measurement plasma PfHRP2 concentrations may reflect total biomass malaria.We...
Artemisinin resistance in Plasmodium falciparum threatens global efforts to control and eliminate malaria. Polymorphisms the kelch domain-carrying protein K13 are associated with artemisinin resistance, but underlying molecular mechanisms unknown. We analyzed vivo transcriptomes of 1043 P. isolates from patients acute malaria found that is increased expression unfolded response (UPR) pathways involving major PROSC TRiC chaperone complexes. Artemisinin-resistant parasites also exhibit...
Evolving resistance to artemisinin-based compounds threatens derail attempts control malaria. Resistance has been confirmed in western Cambodia and recently emerged Thailand, but is absent from neighboring Laos. Artemisinin results reduced parasite clearance rates (CRs) after treatment. We used a two-phase strategy identify genome region(s) underlying this ongoing selective event. Geographical differentiation haplotype structure at 6969 polymorphic single-nucleotide polymorphisms (SNPs) 91...
Since our ancestors began trading several millennia ago, counterfeit and substandard medicines have been a recurring problem, with history punctuated by crises in the supply of anti-microbials, such as fake cinchona bark 1600s quinine 1800s. Unfortunately this problem persists, particular afflicting unsuspecting patients 'developing' countries. Poor-quality drugs are vital (but neglected) public health problem. They contribute to 'crevasse' between enormous effort therapeutic research policy...
Klebsiella pneumoniae is a leading cause of bloodstream infection (BSI). Strains producing extended-spectrum beta-lactamases (ESBLs) or carbapenemases are considered global priority pathogens for which new treatment and prevention strategies urgently required, due to severely limited therapeutic options. South Southeast Asia major hubs antimicrobial-resistant (AMR) K. also the characteristically antimicrobial-sensitive, community-acquired "hypervirulent" strains. The emergence hypervirulent...
Artemisinin and partner-drug resistance in Plasmodium falciparum are major threats to malaria control elimination. Triple artemisinin-based combination therapies (TACTs), which combine existing co-formulated ACTs with a second partner drug that is slowly eliminated, might provide effective treatment delay emergence of antimalarial resistance.
The population of Salmonella enterica serovar Typhi (S. Typhi), the causative agent typhoid fever, exhibits limited DNA sequence variation, which complicates efforts to rationally discriminate individual isolates. Here we utilize data from whole-genome sequences (WGS) nearly 2,000 isolates sourced over 60 countries generate a robust genotyping scheme that is phylogenetically informative and compatible with range assays. These show that, exception rapidly disseminating H58 subclade (now...
Southeast Asia, a vibrant region that has recently undergone unprecedented economic development, is regarded as global hotspot for the emergence and spread of antimicrobial resistance (AMR). Understanding AMR in Asia crucial assessing how to control on an international scale. Here we (i) describe current situation (ii) explore mechanisms make focal AMR, (iii) propose ways which could contribute solution.
MalariaGEN is a data-sharing network that enables groups around the world to work together on genomic epidemiology of malaria. Here we describe new release curated genome variation data 7,000 Plasmodium falciparum samples from partner studies in 28 malaria-endemic countries. High-quality genotype calls 3 million single nucleotide polymorphisms (SNPs) and short indels were produced using standardised analysis pipeline. Copy number variants associated with drug resistance structural cause...
Enteric fever, a systemic infection caused by Salmonella enterica serovars Typhi and Paratyphi A, remains major cause of morbidity mortality in low-income middle-income countries. fever is preventable through the provision clean water adequate sanitation can be successfully treated with antibiotics. However, high levels antimicrobial resistance (AMR) compromise effectiveness treatment. We provide estimates prevalence AMR S A 75 endemic countries, including 30 locations without data.
The production of substandard and fake drugs is a vast underreported problem, particularly affecting poorer countries. Cockburn colleagues argue that the pharmaceutical industry governments must both take action.