Olugbenga Ayodeji Mokuolu
A5067034828- Malaria Research and Control
- Mosquito-borne diseases and control
- Global Maternal and Child Health
- Neonatal Respiratory Health Research
- Child Nutrition and Water Access
- Computational Drug Discovery Methods
- Parasites and Host Interactions
- Pharmaceutical Quality and Counterfeiting
- Poverty, Education, and Child Welfare
- Infant Development and Preterm Care
- Diverse Scientific Research Studies
- Neonatal Health and Biochemistry
- COVID-19 epidemiological studies
- Travel-related health issues
- Economic Growth and Development
- Hemoglobinopathies and Related Disorders
- Pharmaceutical Economics and Policy
- Chronic Kidney Disease and Diabetes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- HIV Research and Treatment
- Neonatal and Maternal Infections
- Drug-Induced Hepatotoxicity and Protection
- Homelessness and Social Issues
- Retinopathy of Prematurity Studies
- Viral Infections and Outbreaks Research
University of Ilorin
2016-2025
University of Ilorin Teaching Hospital
2014-2025
Federal Ministry of Health
2017-2024
Federal Medical Centre
2023
Ahmadu Bello University
2019-2023
University of Ibadan
2023
Centre for Human Genetics
2023
University of Oxford
2023
Utrecht University
2022
Mahidol University
2022
Artemisinin resistance in Plasmodium falciparum has emerged Southeast Asia and now poses a threat to the control elimination of malaria. Mapping geographic extent is essential for planning containment strategies.Between May 2011 April 2013, we enrolled 1241 adults children with acute, uncomplicated malaria an open-label trial at 15 sites 10 countries (7 3 Africa). Patients received artesunate, administered orally daily dose either 2 mg per kilogram body weight day or 4 kilogram, days,...
MalariaGEN is a data-sharing network that enables groups around the world to work together on genomic epidemiology of malaria. Here we describe new release curated genome variation data 7,000 Plasmodium falciparum samples from partner studies in 28 malaria-endemic countries. High-quality genotype calls 3 million single nucleotide polymorphisms (SNPs) and short indels were produced using standardised analysis pipeline. Copy number variants associated with drug resistance structural cause...
Background. Data from the largest randomized, controlled trial for treatment of children hospitalized with severe malaria were used to identify such predictors a poor outcome malaria. Methods. African (<15 years) participated in randomized comparison parenteral artesunate and quinine 9 countries. Detailed clinical assessment was performed on admission. Parasite densities assessed reference laboratory. Predictors death examined using multivariate logistic regression model. Results. Twenty...
Summary Objective To determine the burden of congenital malaria in newborns Nigeria. Methods In a prospective multi‐centre study, 1875 consecutive mother–baby pairs were enrolled over continuous 12‐month period. Blood smears prepared from mothers, neonates, placental aspirates and cord blood within 4 h delivery. Outcome variables patent parasitaemia mother, placenta, neonate addition to maternal neonatal haematocrit. Results Patent was detected 95 neonates (5.1%). The occurrence varied...
Intermittent preventive treatment with sulphadoxine-pyrimethamine (IPT-SP) is currently the recommended regimen for prevention of malaria in pregnancy endemic areas. This study sets out to evaluate effectiveness IPT-SP maternal and placental parturient mothers Ibadan, Nigeria, where risk present all year round. During a larger evaluating epidemiology congenital malaria, effect prophylaxis was examined 983 mothers. Five hundred ninety eight (60.8%) received IPT-SP, 214 (21.8%) pyrimethamine...
<ns3:p>MalariaGEN is a data-sharing network that enables groups around the world to work together on genomic epidemiology of malaria. Here we describe new release curated genome variation data 7,000 <ns3:italic>Plasmodium falciparum</ns3:italic> samples from MalariaGEN partner studies in 28 malaria-endemic countries. High-quality genotype calls 3 million single nucleotide polymorphisms (SNPs) and short indels were produced using standardised analysis pipeline. Copy number variants associated...
In Nigeria, over 900,000 children under the age of five years die every year. Early neonatal death is responsible for a little 20% these deaths. Prematurity remains significant cause early some series, it reported to be 60-70% This study aimed determine prevalence and determinants pre-term deliveries at University Ilorin Teaching Hospital, Ilorin. was prospective cohort conducted 9-month period Hospital. Records data on maternal socio-biological antenatal variables were collected during this...
Estimates of Plasmodium falciparum migration may inform strategies for malaria elimination. Here we elucidate fine-scale parasite population structure and infer recent across Southeast Asia using identity-by-descent (IBD) approaches based on genome-wide single nucleotide polymorphisms called in 1722 samples from 54 districts. IBD estimates are consistent with isolation-by-distance. We observe greater sharing larger segments between artemisinin-resistant parasites versus sensitive parasites,...
Abstracts in ,عريب 中文, Français, Pусский and Español at the end of
Nigeria has the largest number of malaria-related deaths, accounting for a third global malaria deaths. It is important that country attains universal coverage key interventions, one which policy testing before treatment, recently adopted. However, there dearth data on its implementation in formal private health facilities, where close to population seek care. This study identified level use rapid diagnostic (RDT), compliance with test results and associated challenges facilities Nigeria. A...
Accurate assessment and monitoring of the Plasmodium falciparum Kelch 13 ( pfk13) gene associated with artemisinin resistance is critical to understand emergence spread drug-resistant parasites in malaria-endemic regions. In this study, we evaluated genomic profile pfk13 P . Nigerian children by targeted sequencing gene. Genomic DNA was extracted from 332 dried blood (DBS) spot filter paper samples three States. The amplified nested polymerase chain reaction (PCR), amplicons were sequenced...
Abstract Nigeria accounts for 39% of global malaria deaths in children under 5 years age and the effective management severe is a health priority. The Annual Severe Malaria Stakeholders Workshop, held on 5–6th July 2023 Abuja, brought together representatives from 36 States, Federal Capital Territory, other key stakeholders to address across all levels service. Aims were provide updates review progress activities, burden disease, commodity logistics management, pre-referral national policy...
Background The World Health Organization (WHO) non-laboratory cardiovascular disease (CVD) risk chart is sub-region-specific and advocated in resource-constrained settings. However, the extent of agreement with laboratory-based assessment among hypertensive adults attending primary health centers (PHCs) West Africa sub-region remains unknown. This study compared 10-year CVD hypertension PHCs Ghana Nigeria. Materials Methods cross-sectional recruited 319 at All participants had their blood...
The use of pre-referral injectable artesunate is among the strategies adopted to improve outcome childhood severe malaria in Nigeria. However, extent its implementation and impact on outcomes remain unknown. This study assessed treatment with for malaria, associated factors, hospitalisation (discharge or death) a cohort children managed at secondary health facility cross-sectional included diagnosed admitted Data other medications, demographics, clinical features, were prospectively gathered...
In Nigeria, most research and malaria vector control efforts have focused on primary vectors within the Anopheles gambiae complex, with less emphasis other secondary vectors. Consequently, understudied demonstrated a proportional increasing role in transmission. This study utilized geospatial models to understand potential distribution of anopheline species than An . complex (non- species) Nigeria. Adult mosquitoes were sampled monthly between 2020 2022, concurrent surveys larval sites...
Background . To evaluate the current status of malaria at parturition and its impact on delivery outcome in Nigeria. Methods A total 2500 mother-neonate pairs were enrolled 4 sites over a 12-month period. Maternal placental blood smears for parasitaemia haematocrit determined. Results Of subjects enrolled, 625 excluded from analysis because breach study protocol. The mean age remaining 1875 mothers was 29.0<mml:math...
The efficacies of 3-day regimens artemether-lumefantrine (AL), artesunate-amodiaquine (AA), and dihydroartemisinin-piperaquine (DHP) were evaluated in 910 children < 5 years old with uncomplicated malaria from six geographical areas Nigeria. Parasite positivity 1 day Kaplan-Meier estimated risk persistent parasitemia 3 days after therapy initiation both significantly higher, geometric mean parasite reduction ratio treatment (PRRD1) was lower AL-treated than AA- DHP-treated children. No...
The types and frequency of drug use among 1200 students aged 10-19 years was investigated a prevalence rate 40.1% found; currently used drugs included mild stimulants such as kolanut coffee 294 (26.2%), alcohol 164 (14.5%), sniffing agents 80 (7.2%), amphetamine ephedrine 66 (6.7%), cigarette 54 (4.8%), heroin 45 (4%) cocaine 40 (3.6%) cannabis 38 (3.4%). Multiple found the students, with abuse cannabis, being significant those who smoked ( P<0.001). relative risk (RR) for when 37.4...
Since congenital malaria had previously been thought to be rare, blood film examination for parasites is still sometimes not routinely performed in ill neonates malaria-endemic regions. Because of increasing published reports Nigeria, there a need characterize the clinical and laboratory manifestations associated with parasitemia within first few hours life. In 12-month (April 2003-March 2004), multicenter study thin thick smears made from maternal (finger prick), placental aspirates, cord...