A5076827301- Pharmaceutical Economics and Policy
- Neuroscience and Neuropharmacology Research
- Pharmaceutical Quality and Counterfeiting
- Receptor Mechanisms and Signaling
- Regulation of Appetite and Obesity
- Neuropeptides and Animal Physiology
- Biochemical Analysis and Sensing Techniques
- Health Systems, Economic Evaluations, Quality of Life
- Neurotransmitter Receptor Influence on Behavior
- Pharmaceutical studies and practices
- melanin and skin pigmentation
- Stress Responses and Cortisol
- Pharmaceutical industry and healthcare
- Pharmacovigilance and Adverse Drug Reactions
- Pharmaceutical Practices and Patient Outcomes
- Ethics in Clinical Research
- Biomedical Ethics and Regulation
- Treatment of Major Depression
- Anesthesia and Neurotoxicity Research
- Neuroendocrine regulation and behavior
- Hormonal Regulation and Hypertension
- GABA and Rice Research
- Analytical Chemistry and Chromatography
- Plant-based Medicinal Research
- Drug Solubulity and Delivery Systems
Centre d'Imagerie BioMedicale
2024
World Health Organization
2003-2016
Instituto de Neurociencias
2015
Consejo Superior de Investigaciones Científicas
2015
World Health Organization - Pakistan
2002-2014
Max Planck Institute of Immunobiology and Epigenetics
2014
University of Freiburg
2014
Technologies pour la Santé
2014
nLIGHT (United States)
2006
Improvement Service
2006
Several novel cyclic MSH analogs were synthesized, and their binding properties tested on cells transiently expressing the human melanocortin-1 (MC1), MC3, MC4, MC5 receptors. We discovered a substance (HS024) that showed about 20-fold selectivity very high affinity (Ki = 0.29 nM) for MC4 receptor. HS024 (cyclic [AcCys3,Nle4,Arg5,D-Nal7,Cys-NH2(11)]alpha-MSH-(3-11)) has 29-membered atom ring structure includes an Arg in position 5. was found to antagonize alphaMSH-induced cAMP response MC1,...
a. Definition. Clinical pharmacology is the scientific discipline that involves all aspects of relationship between drugs and humans. The term 'clinical pharmacologist' also used in professional sense to refer those physicians who are specialists clinical pharmacology. They have undertaken several years postgraduate training many above involving teaching, research health care. Such pharmacologists as their primary goal improving patient care, directly or indirectly, by developing better...
1 Experiments were conducted to evaluate the effects of novel non-peptide neuropeptide Y Y1 receptor antagonist, BIBP3226 (N2-(diphenylacetyl)-N-[(4-hydroxy-phenyl)methyl]-d-arginine amide) on spontaneous, fasting-induced and NPY-induced food intake in rats. In addition consumption regular chow, highly palatable sweetened mash monitored a h test first exposure after familiarization with food. 2 (10.0 nmol, i.c.v.) had no effect but reduced significantly diet stimulated by fasting (24 h)....
The International Conference on Harmonisation (ICH) is an unparalleled undertaking, which has brought together drug regulatory authorities and pharmaceutical trade associations from Europe, Japan, the United States, to discuss scientific technical aspects of medical product registration. Launched in 1990, value benefits ICH regulators are being realized. harmonized submission requirements created a format that relieving both companies burdens assembling reviewing separate submissions for...
Pahkla R, Zilmer M, Kullisaar T, Rago L. Comparison of the antioxidant activity melatonin and pinoline in vitro. J. Pineal Res. 1998; 24:96–101. © Munksgaard, Copenhagen Abstract Several recent experiments have shown that is an efficient free radical scavenger. In present study antioxidative effect was compared with pinoline. Pinoline (6‐methoxy‐tetrahydro‐β‐carboline) can be formed mammalian body under physiological conditions from 5‐hydroxytryptamine or as a tricyclic metabolite melatonin....
In the developing telencephalon, medial ganglionic eminence (MGE) generates many cortical and virtually all striatal interneurons. While molecular mechanisms controlling migration of interneurons to cortex have been extensively studied, very little is known about nature signals that guide striatum. Here we report allocation MGE-derived in striatum mouse relies on a combination chemoattractive chemorepulsive activities. Specifically, migrate toward response Nrg1/ErbB4 chemoattraction, avoid...
IN this study we investigated the long term effects of a potent and selective melanocortin 4 (MC4) receptor antagonist (HS014) on food intake, body weight, composition blood glucose levels in adult rats. HS014 was injected i.c.v. either by twice-daily injections (2 × 1 nmol) for 6 days or administered continuous infusion with osmotic minipumps (0.16 nmol/h) 2 weeks. The results show considerable increase intake weight after both treatments without any signs tachyphylaxis. After weeks...