A5088385522- Cardiovascular Health and Disease Prevention
- Cardiac Ischemia and Reperfusion
- Probiotics and Fermented Foods
- Blood Pressure and Hypertension Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Gut microbiota and health
- Adipokines, Inflammation, and Metabolic Diseases
- Anesthesia and Neurotoxicity Research
- Tryptophan and brain disorders
- Cerebrovascular and Carotid Artery Diseases
- Metabolomics and Mass Spectrometry Studies
- Nitric Oxide and Endothelin Effects
- Heart Rate Variability and Autonomic Control
- Microbial Metabolites in Food Biotechnology
- Cardiovascular Disease and Adiposity
- Exercise and Physiological Responses
- Thermoregulation and physiological responses
- Peripheral Artery Disease Management
- Antioxidant Activity and Oxidative Stress
- Sulfur Compounds in Biology
- Aortic Disease and Treatment Approaches
- Neuroscience and Neuropharmacology Research
- Folate and B Vitamins Research
- Alzheimer's disease research and treatments
- Biochemical effects in animals
University of Tartu
2016-2025
Tartu University Hospital
1996-2021
Bio-Competence Centre of Healthy Dairy Products (Estonia)
2012
University of Copenhagen
2010
AstraZeneca (Brazil)
2005
Karolinska University Hospital
2003
Stockholm South General Hospital
1998
Stockholm University
1995
Analyses of circulating metabolites in large prospective epidemiological studies could lead to improved prediction and better biological understanding coronary heart disease (CHD). We performed a mass spectrometry-based non-targeted metabolomics study for association with incident CHD events 1,028 individuals (131 events; 10 y. median follow-up) validation 1,670 (282 3.9 follow-up). Four were replicated independent main cardiovascular risk factors [lysophosphatidylcholine 18∶1 (hazard ratio...
This study aimed to investigate the relationship between oxidative stress and endothelium-dependent vasodilation in patients with chronic renal failure (CRF). Thirty-seven CRF underwent evaluation of endothelium-independent by means forearm blood flow measurements venous occlusion plethysmography during local intra-arterial infusions methacholine (evaluating vasodilation) sodium nitroprusside vasodilation). Lag phase lipoprotein fraction oxidation, total antioxidative activity, diene...
The increasing interest in a healthy diet is stimulating innovative development of novel scientific products the food industry. viable lactic acid bacteria fermented milk products, such as yoghurt, have been associated with increased lactose tolerance, well-balanced intestinal microflora, antimicrobial activity, stimulation immune system and antitumoural, anticholesterolaemic antioxidative properties human subjects. Recently, we studied Lactobacillus spp. strain that possesses activity. aim...
Aims: To use antioxidative activity and antagonistic properties of lactobacilli against selected pathogens members the normal microflora as a basis for screening probiotic candidates. Methods Results: Antagonistic target bacteria in both microaerobic anaerobic environments was tested. Production metabolites (ethanol, hydrogen peroxide (H2O2), acetic, lactic succinic acid) by well their total were assessed. In general, tested most effective Gram-negative strain-specific. However, obligately...
The paper lays out the short scientific history and characteristics of new probiotic Lactobacillus fermentum strain ME-3 DSM-14241, elaborated according to regulations WHO/FAO (2002). L. is a unique species, having at same time antimicrobial physiologically effective antioxidative properties expressing health-promoting if consumed. Tartu University has patented this in Estonia (priority June 2001, patent 2006), Russia (patent 2006) USA 2007). describes process identification molecular typing...
The aim of this study was to investigate the effects vasodilating β-blocker nebivolol and cardioselective metoprolol succinate on aortic blood pressure left ventricular wall thickness. We conducted a randomized, double-blind 80 hypertensive patients. patients received either 5 mg or 50 100 daily for 1 year. Their heart rate, central brachial pressures, mean arterial pressure, augmentation index, carotid-femoral pulse wave velocity, thickness were measured at baseline end study. Nebivolol...
In persons without clinical symptom it is difficult to assess an impact of probiotics regarding its effect on health. We evaluated the functional efficacy probiotic Lactobacillus fermentum ME-3 in healthy volunteers by measuring influence two different formulations intestinal lactoflora, fecal recovery strain and oxidative stress markers blood urine after 3 weeks consumption.
Reactive oxygen and nitrogen species produced by metabolism immune defenses can cause extensive damage to biomolecules. To counteract this damage, organisms rely on exogenous endogenous antioxidants, although their relative importance in maintaining redox balance is unclear. We supplemented captive greenfinches with dietary antioxidants—carotenoids vitamin E—and injected them an inflammatory agent, phytohemagglutinin. Compared controls, immune‐challenged birds circulated more lipid...
Costs accompanying immune challenges are believed to play an important role in life-history trade-offs and warranting the honesty of signal traits. We performed experiment captive greenfinches (Carduelis chloris L.) order test whether how humoral challenge with non-pathogenic antigen [sheep red blood cells (SRBC)] affects parameters individual condition including intensity coccidian infection, estimates total antioxidant protection, plasma carotenoids ability mount a cell-mediated response....
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in clinical practice. The pathogenesis of AF linked to inflammatory reaction and oxidative stress, which leads fibrosis atria progression disease. purpose this study was define role several biomarkers inflammation, fibrosis, stress (OxS). We included 75 patients with paroxysmal/persistent AF, who were admitted for electrical cardioversion or pulmonary vein isolation (PVI). High-sensitivity C-reactive protein (hsCRP),...
The possible beneficial effect of regular aquatic exercise on cardiorespiratory, renal lipid parameters and oxidative stress status was studied in patients with mild to moderate failure. group did low-intensity aerobic the pool during a period 12 weeks, twice week, sessions lasting for 30 min. Matched control participants remained sedentary. results showed that all cardiorespiratory functional improved resting blood pressure lowered significantly. Proteinuria cystatin-C were diminished...
The relationship between exhaustive exercise, oxidative stress, the protective capacity of antioxidant defense system and cellular immune response has been determined. Exhaustive exercise in well-trained young men (n=19)-induced leukocytosis, decreased proportion activated-lymphocyte subsets (CD4+ CD8+) expressing CD69, lymphocyte mitogenic to concanavalin A (ConA) phytohemagglutinin (PHA), increased lipid peroxidation, total status (TAS) catalase activity, immediately after exercise....
Several studies have shown increased prevalence of obesity in patients with psoriasis.To characterize both inflammatory- and oxidative stress-related differences between obese psoriasis (OPP) normal-weight (NWPP).The plasma concentrations adiponectin interleukin (IL)-6 were analysed by quantitative sandwich enzyme immunoassay technique 10 a body mass index (BMI)<25 12 BMI>30. Total glutathione oxidized levels measured spectrophotometrically.Plasma concentration NWPP was more than twice the...
<b><i>Background/Aims:</i></b> Many inflammation parameters are associated with obesity, but few comparable data found in youth. This study aims to characterize the differences serum levels of 13 biochemical inflammatory markers between boys increased BMI and normal BMI, examine relationships markers, skinfold thicknesses, body composition. <b><i>Participants/Methods:</i></b> The participants were 38 (BMI above 85th percentile) (normal BMI) at...