A5102908847- Archaeology and Natural History
- Law, Economics, and Judicial Systems
- Legal principles and applications
- Chemotherapy-induced cardiotoxicity and mitigation
- Pharmaceutical Quality and Counterfeiting
- Medical Malpractice and Liability Issues
- Malaria Research and Control
- Cancer Treatment and Pharmacology
- Criminal Law and Evidence
- Legal Systems and Judicial Processes
- Corporate Law and Human Rights
- Conflict of Laws and Jurisdiction
- American Constitutional Law and Politics
- European and International Contract Law
- American Environmental and Regional History
- Identification and Quantification in Food
- Indigenous Studies and Ecology
- Colonialism, slavery, and trade
- Mass Spectrometry Techniques and Applications
- Electron Spin Resonance Studies
- Pharmaceutical Economics and Policy
- Cytomegalovirus and herpesvirus research
- Pesticide Residue Analysis and Safety
- Botany, Ecology, and Taxonomy Studies
- Water Governance and Infrastructure
Duke University
2022-2025
University of Pittsburgh
1995-2025
Duke University Hospital
2023
Duke Medical Center
2023
Wake Forest University
2005-2021
Centers for Disease Control and Prevention
1995-2021
Division of Parasitic Diseases and Malaria
2009-2021
Dartmouth College
1983-2020
Williams (United States)
2019
Medical University of South Carolina
2018
Studies in animals suggest that the bispiperazinedione ICRF-187 can prevent development of dose-related doxorubicin-induced cardiac toxicity. In a randomized trial 92 women with advanced breast cancer, we compared treatment fluorouracil, doxorubicin, and cyclophosphamide (FDC), given every 21 days, same regimen preceded by administration (FDC+ICRF-187). Patients were withdrawn from study when toxicity developed or cancer progressed. The mean cumulative dose doxorubicin tolerated patients was...
Since our ancestors began trading several millennia ago, counterfeit and substandard medicines have been a recurring problem, with history punctuated by crises in the supply of anti-microbials, such as fake cinchona bark 1600s quinine 1800s. Unfortunately this problem persists, particular afflicting unsuspecting patients 'developing' countries. Poor-quality drugs are vital (but neglected) public health problem. They contribute to 'crevasse' between enormous effort therapeutic research policy...
Vacuum is not the limit: direct analysis in real time (DART), a new MS ionization method, allows probing of pharmaceuticals under atmospheric pressure, thus bypassing lengthy sample preparation steps and enhancing throughput. DART rapid screening solid drugs at almost constant temperature which decreases errors mass measurement improves identification potentially harmful unknowns. This important for identifying counterfeit (fake hologram shown).
Desorption electrospray ionization mass spectrometry (DESI MS) is rapidly becoming accepted as a powerful surface characterization tool for wide variety of samples in the open air. Besides its well-established high-throughput capabilities, unique feature DESI that chemical reactions between charged spray microdroplets and molecules can be exploited to enhance ionization. Here, we present rapid screening assay artesunate antimalarials based on reactive DESI. Artesunate vital therapy...
Abstract During the last decade there has been an apparent increase in prevalence of counterfeit medicines developing as well developed countries. The pivotal antimalarial artesunate counterfeited on a large scale SE Asia. In this work, possibilities Raman spectroscopy are explored fast and reliable screening method for detection tablets. study, 50 ‘artesunate tablets’, purchased Asia, were examined. This spectroscopic was able to distinguish between genuine identify composition These...
In southeast Asia, the widespread high prevalence of counterfeits tablets vital antimalarial artesunate is great public health concern. To assess seriousness this problem, we quantified amount active ingredient present in by liquid chromatography coupled to mass spectrometry. This method, conjunction with analysis packaging, classified as genuine, substandard, or fake and validated results colorimetric Fast Red TR test. Eight (35%) 23 samples contained wrong ingredients, which were...
Although doxorubicin is an anticancer agent with a wide spectrum of activity, therapy this anthracycline must often be discontinued at time benefit to the patient because drug's cumulative cardiotoxicity. ICRF-187 (ADR-529, dexrazoxane) bisdioxopiperazine compound that protects against cardiac toxicity induced by doxorubicin.Our objectives in study were determine maximum tolerated dose ADR-529 (which uses different vehicle than ICRF-187) when given fixed and whether alters...
The direct quantitation of active ingredients in solid pharmaceutical tablets by desorption electrospray ionization mass spectrometry (DESI MS) is complicated the dependence DESI signal on variables such as spray angles and distances, morphological sample properties, difficulty properly incorporating an internal standard. Here, a MS method for quantitative screening widely counterfeited antimalarial containing artesunate presented. This based reactive DESI, where analyte occur formation...
Abstract Background Counterfeit oral artesunate has been a major public health problem in mainland SE Asia, impeding malaria control. A countrywide stratified random survey was performed to determine the availability and quality of pharmacies outlets (shops selling medicines) Lao PDR (Laos). Methods In 2003, 'mystery' shoppers were asked buy tablets from 180 12 18 provinces. Outlets selected using sampling by investigators not involved sampling. Samples analysed for packaging...
Abstract Background Human Adenovirus (HAdV) can cause life-threatening illness in pediatric allo-HCT recipients, but studies to define incidence and outcomes of HAdV patients are limited. Use PCR-based surveillance varies by HCT center, part because there no approved HAdV-directed therapies. This study describes the epidemiology infection disease who did not undergo surveillance. Methods An cohort was assembled from July 2018 June 2021 at ten US centers. Patients were followed for 180 days...
Racial and ethnic disparities in cardiovascular disease (CVD) risk factors are well-documented. However, racial differences the longitudinal changes among multiple CVD unknown. We used prospective cohort data of U.S. adults aged ≥50 2006-2016 Health Retirement Study. Group-based multi-trajectory models characterized age-related trajectories systolic blood pressure ([BP] mmHg), non-HDL cholesterol (mg/dL), diabetes mellitus (DM), smoking. profiles were examined using multinomial logistic...
Importance Discrimination in healthcare disrupts trust and can negatively influence patients. However, the impact of experiencing discrimination on long-term patterns utilization is unknown. Objective To assess how perceived settings associated with longitudinal doctor visits among middle-aged older adults United States. Design Prospective cohort study US Health Retirement Study (HRS) who were followed every 2 years for up to 14 (2008–2020). Setting population-based study. Participants...
Introduction: Discrimination in healthcare strains patient-provider relationships and may contribute to disparities outcomes. When patients feel disrespected, they could be less likely trust providers or seek follow-up care, which poses a challenge for cardiovascular risk management. We assessed the association between discrimination incidence of stroke. Methods: used nationally-representative longitudinal data from 2008-2020 Health Retirement Study examine stroke healthcare. Participants...
The availability of falsified antimalarial drugs can be reduced with effective drug regulatory agencies and proper enforcement. Fundamental to these taking action, rapid identification must made as soon they appear in the market place. Since antimalarials occur mostly developing countries, performing analysis presents itself unique challenges. A fundamental factor choosing a useful technique is affordability simplicity. Therefore, we suggest three-tiered evaluation strategy for identifying...
Importance Although understudied, there are likely within-group differences among minoritized racial and ethnic groups in associations between discrimination (RED) hypertension risk, as individuals with higher educational attainment may more frequently encounter stress-inducing environments (eg, professional workplace settings, higher-income stores neighborhoods) characterized by, for instance, exclusion antagonism. Objectives To investigate a potential effect modifier of RED risk US women;...