Racial and ethnic disparities in cardiovascular disease (CVD) risk factors are well-documented. However, racial differences the longitudinal changes among multiple CVD unknown. We used prospective cohort data of U.S. adults aged ≥50 2006-2016 Health Retirement Study. Group-based multi-trajectory models characterized age-related trajectories systolic blood pressure ([BP] mmHg), non-HDL cholesterol (mg/dL), diabetes mellitus (DM), smoking. profiles were examined using multinomial logistic...

Abstract Background and Objectives Low education in early-life is a major risk factor for dementia. However, little known about how later life related to cognitive function older adults. We assessed whether later-life learning was associated with better over time the associations differed by sex, race/ethnicity, prior education. Research Design Methods used data from 2008-2018 Health Retirement Study, included participants aged 65+ without baseline dementia followed up 6 years. Global...

Importance Discrimination in healthcare disrupts trust and can negatively influence patients. However, the impact of experiencing discrimination on long-term patterns utilization is unknown. Objective To assess how perceived settings associated with longitudinal doctor visits among middle-aged older adults United States. Design Prospective cohort study US Health Retirement Study (HRS) who were followed every 2 years for up to 14 (2008–2020). Setting population-based study. Participants...

Obstructive sleep apnea (OSA) is common in commercial motor vehicle operators (CMVOs); however, polysomnography (PSG), the gold-standard diagnostic test, expensive and inconvenient for screening. OSA associated with changes heart rate voltage on electrocardiography (EKG). We evaluated utility of EKG parameters identifying CMVOs at greater risk sleepiness-related crashes (apnea-hypopnea index [AHI] ≥ 30 events/h).In this prospective study CMVOs, we performed EKGs concurrent PSG, calculated...

Sub-optimal diet and physical activity (PA) levels have been associated with increased risk of cardiovascular disease (CVD) mortality. The relationship between pre-cancer diagnosis quality PA level on CVD mortality in cancer survivors is unclear. We examined the association leisure-time their interaction survivors. Diet was characterized by Alternative Mediterranean Index (aMED). Leisure-time converted to a metabolic equivalent task hours per week (MET-h/wk). During median 6.3 years...

The Ehlers-Danlos syndromes (EDSs) are a group of heritable disorders connective tissue associated with an increased prevalence both structural and functional GI conditions.We used 10 years (2005-2014) administrative claims data comprised 4294 people clinician-diagnosed EDS, aged 5-62 years, compared their frequency drug prescription to age-, sex-, state residence-, earliest claim date-matched controls. We categorized the medications into following groups: acid suppressants, anti-emetics,...

We examined the relationship between baseline cardiovascular (CV) disease/risk factors and longitudinally-collected scores on patient health questionnaire (PHQ-9) depression scale using an outpatient sample of individuals with mental illness (PCARES Registry, 2015–2020). Individuals ≥2 repeated PHQ-9 assessments over one-year from measurement (N = 2110) were included for trajectory modeling, five symptom severity groups determined a priori (lowest, lower, middle, higher, highest)....

Background. Cardiovascular disease (CVD) and depression are the leading causes of disability in U.S. Using electronic health record data, we describe CVD burden among persons with mental illness enrolled Penn State Psychiatry Clinical Assessment Rating Evaluation System (PCARES) Registry between 2015 2020. Methods. assessment included prevalence conditions (any major or individual risk factors), indicated medication prescriptions for factors, mean levels body mass index (BMI, kg/m2),...

BACKGROUND: Socioeconomic disadvantage is associated with greater risks of hospital readmission and mortality among patients heart failure (HF). However, it less clear whether socioeconomic has an immediate lasting impact on the risk admissions after diagnosis HF. METHODS: We used electronic health record data aged 65 years older newly diagnosed HF between January 2015 July 2018 in Duke University Health System, up to 8 follow-up. assessed association neighborhood-level disadvantage,...

Abstract Racial/ethnic disparities in major cardiovascular disease (CVD) risk factors are well documented. However, studies have not considered racial/ethnic differences the interrelationships among these CVD and how they vary across age. We used six waves of longitudinal data from Health Retirement Study ([HRS] 2006-2016; n=10,292) to examine co-occurring changes systolic blood pressure ([BP] mmHg), non-HDL cholesterol (mg/dl), diabetes (y/n), smoking (y/n) at ages 50-80. Group-based...

Abstract Little is known about racial/ethnic differences in the long-term patterns of hospitalization following diagnosis heart failure (HF). We examined trajectories hospital admissions a HF and assessed factors contributing to risks hospitalization. included 5,606 patients with newly-diagnosed between January 2015 July 2018 Duke University Health System followed them for up five years. Group-based trajectory models were used identify all-cause HF. Multinomial logistic regression patient...

Abstract The association between socioeconomic status and 30-day readmissions is well-documented in patients with heart failure (HF). However, it less clear whether disadvantage has an immediate and/or lasting impact on risk of hospital admissions following the diagnosis HF. We examined area-level was associated early recurrent risks hospitalizations diagnosed included 5,889 (ages 65-85 years) newly HF January 2015 July 2018 Duke University Health System followed them for up to eight years....

Abstract Background Little is known about how education in later life related to cognitive function older adults. This study assessed whether participating later‐life was associated with better over time and the benefits differed by sex, race/ethnicity, prior level a nationally‐representative sample of U.S. Method We conducted retrospective cohort using six waves data from Health Retirement Study ([HRS] 2008‐2018) that included adults aged ≥ 65 years no baseline diagnosis dementia. Cognitive...

Objective: To investigate whether the severity of depression symptoms is associated with poor long-term control plasma glucose levels in individuals type 2 diabetes. Methods: Electronic health record [EHR] data 2842 mental illness enrolled Penn State Clinical Assessment and Rating Evaluation System [PCARES] registry were used. Demographics, body mass index [BMI], baseline diabetes mellitus [T2DM] status all available labs extracted from EHR. The nine-item patient questionnaire [PHQ-9] was...

Objective: To understand the burden of cardiovascular diseases (CVDs) in a psychiatric outpatient population. Methods: We used baseline data from ongoing Penn State Psychiatry Clinical Assessment and Rating Evaluation System (PCARES) Registry, which is comprised adult patients who were seen at clinic affiliated with Department Behavioral Health Milton S. Hershey Medical Center. The Electronic Record (EMR) 3,024 sought care between 02/17/2015 09/18/2019 included this report. compared...

Joint hypermobility in Ehlers-Danlos Syndromes (EDS) predisposes persons with EDS to frequent subluxations and dislocations, chronic arthralgia, soft-tissue rheumatism. Epidemiologic trends of rheumatologic conditions among are lacking. Prescription claims databases can reflect underlying disease burdens by using medication as proxies. We examined the prevalence prescription for commonly prescribed immunomodulator antiinflammatory (IMD) drugs compared their matched control person,...

Better diet quality and higher physical activity (PA) levels have been associated with lower risk of cardiovascular disease (CVD) mortality, but the relationship between pre- cancer diagnosis PA level on CVD mortality in survivors is unclear. We examined association pre-cancer leisure time PA, their interaction, survivors. Female who were diagnosed during follow-up had no history cancer, stroke, or heart attack at baseline identified. Analyses excluded: (1) participants lived outside...