A5070518026- Metabolism and Genetic Disorders
- Neonatal Health and Biochemistry
- Advanced Chemical Sensor Technologies
- Indoor Air Quality and Microbial Exposure
- Carcinogens and Genotoxicity Assessment
- Air Quality and Health Impacts
- Smoking Behavior and Cessation
- Lysosomal Storage Disorders Research
- Blood groups and transfusion
- Metabolomics and Mass Spectrometry Studies
- Health, Environment, Cognitive Aging
- Blood disorders and treatments
- Biosimilars and Bioanalytical Methods
- Genomics and Rare Diseases
- Mitochondrial Function and Pathology
- Erythrocyte Function and Pathophysiology
- Cannabis and Cannabinoid Research
- Biomedical Research and Pathophysiology
- Diet and metabolism studies
- Analytical Chemistry and Chromatography
- Air Quality Monitoring and Forecasting
- Occupational exposure and asthma
- Biochemical and Molecular Research
- Clinical Laboratory Practices and Quality Control
- Sulfur Compounds in Biology
Centers for Disease Control and Prevention
2014-2023
National Center for Environmental Health
2010-2022
Agios Pharmaceuticals (United States)
2020
CDC Foundation
2020
University of Holguín
2013-2015
Memorial Medical Center
2012
Georgia Institute of Technology
2005-2007
National Center for Infectious Diseases
2007
Georgia Tech Research Institute
2006-2007
The causative agents for the current national outbreak of electronic-cigarette, or vaping, product use-associated lung injury (EVALI) have not been established. Detection toxicants in bronchoalveolar-lavage (BAL) fluid from patients with EVALI can provide direct information on exposure within lung.BAL fluids were collected 51 16 states and 99 healthy participants who part an ongoing study smoking involving nonsmokers, exclusive users e-cigarettes vaping products, cigarette smokers that was...
CDC, the Food and Drug Administration (FDA), state local health departments, multiple public clinical partners are investigating a national outbreak of e-cigarette, or vaping, product use-associated lung injury (EVALI). Based on data collected as October 15, 2019, 86% 867 EVALI patients reported using tetrahydrocannabinol (THC)-containing products in 3 months preceding symptom onset (1). Analyses THC-containing samples by FDA laboratories have identified potentially harmful constituents...
Desorption electrospray ionization mass spectrometry (DESI MS) is rapidly becoming accepted as a powerful surface characterization tool for wide variety of samples in the open air. Besides its well-established high-throughput capabilities, unique feature DESI that chemical reactions between charged spray microdroplets and molecules can be exploited to enhance ionization. Here, we present rapid screening assay artesunate antimalarials based on reactive DESI. Artesunate vital therapy...
Lysosomal storage disorders (LSDs) comprise more than 40 genetic diseases that result in the accumulation of products would normally be degraded by lysosomal enzymes. A tandem mass spectrometry (MS/MS)-based method is available for newborn screening 5 LSDs, and many laboratories are initiating pilot studies to evaluate incorporation this into their panels. We developed evaluated dried blood spot (DBS) QC materials LSDs used MS/MS investigate suitability LSD monitoring.We incubated 3.2-mm...
Dried blood spots (DBS) have been used in newborn screening (NBS) tests for over 50 years. The Newborn Screening Quality Assurance Program (NSQAP) at the Centers Disease Control and Prevention (CDC) conducted studies to assess individual impacts of hematocrit total-spot volume on characteristics DBS samples. Per-punch serum volumes decreased 27%, RBC more than doubled, absorption times increased 300%, spot diameters marginally between hematocrits 40% 65%. logarithmically with lowering...
In longitudinal studies of adults, elevated amino acid (AA) concentrations predicted future type 2 diabetes mellitus (T2DM).The aim the present investigation was to examine whether increased plasma AA are associated with impaired β-cell function relative insulin sensitivity [i.e. disposition index (DI)], a predictor T2DM development.Metabolomic analysis for fasting AAs performed by tandem mass spectrometry in 139 normal-weight and obese adolescents without dysglycemia. First-phase secretion...
How carcinogen exposure varies across users of different, particularly noncigarette, tobacco products remains poorly understood.
Background: The Newborn Screening Quality Assurance Program at the Centers for Disease Control and Prevention assesses adherence to established performance standards of manufactured lots whole blood filter paper collection devices that are registered by US FDA. We examined 26 newborn screening analytes measured from applied papers two FDA-cleared sources, Whatman® Grade 903 Ahlstrom 226. dried spots contained both single levels dose–response series. Results: observed overlap one standard...
Lysozomal storage disorders are just beginning to be routinely screened using enzyme activity assays involving dried blood spots and tandem mass spectrometry (MS/MS). This paper discusses some of the analytical challenges associated with published including complex sample preparation potential interference from excess residual substrate. Solutions these presented in form on-line two-dimensional chromatography eliminate off-line liquid-liquid extraction (LLE) solid-phase (SPE), use...
Sources of human aldehyde exposure include food additives, combustion organic matter (tobacco smoke), water disinfection byproducts via ozonation, and endogenous processes. Aldehydes are potentially carcinogenic mutagenic, chronic has raised concerns about potential deleterious health effects. To aid investigations exposure, we developed a novel method to measure 19 aldehydes released from Schiff base protein adducts in serum using controlled acid hydrolysis, solid-phase microextraction...
Volatile organic compounds (VOCs) are ubiquitous in the environment. In United States (U.S.), tobacco smoke is major non-occupational source of exposure to many harmful VOCs. Exposure VOCs can be assessed by measuring their urinary metabolites (VOCMs). The Population Assessment Tobacco and Health (PATH) Study a U.S. national longitudinal study use adult youth civilian non-institutionalized population. We measured 20 VOCMs urine specimens from subsample adults Wave 1 (W1) (2013-2014)...
Hairdressers are exposed to volatile organic compounds (VOCs), many of which have been linked acute and chronic health effects. Those hairdressers serving an ethnic clientele may potentially experience disproportionate exposures from frequent use products containing VOCs or different VOC concentrations contained in marketed the specific needs their clientele. However, no biomonitoring studies investigated occupational this population. In present pilot study, we sought characterize exposure...
Newborn screening is the largest genetic testing effort in United States and considered one of ten great public health achievements during first 10 years 21st century. For over 35 years, Screening Quality Assurance Program (NSQAP) at US Centers for Disease Control Prevention has helped NBS laboratories ensure that their does not delay diagnosis, minimizes false-positive reports, sustains high-quality performance. It a multi-component program provides comprehensive quality assurance services...
Studies of exposure to petroleum (crude oil/fuel) often involve monitoring benzene, toluene, ethylbenzene, xylenes (BTEX), and styrene (BTEXS) because their toxicity gas-phase prevalence, where is typically by inhalation. However, BTEXS levels in the general U.S. population are primarily from tobacco smoke, smokers have blood on average up eight times higher than nonsmokers. This work describes a method using partition theory artificial neural network (ANN) pattern recognition classify...
Abstract Background: There is little information on human exposure to carcinogens and other toxicants related opiate use, alone or in combination with tobacco. Methods: Among male participants of the Golestan Cohort Study Northeast Iran, we studied 28 never users either opiates tobacco, 33 exclusive cigarette smokers, 23 smoked opiates, 30 who also cigarettes (dual users; 21 9 ingested them). We quantified urinary concentrations 39 biomarkers, including tobacco alkaloids, tobacco-specific...