A5080397344- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Esophageal Cancer Research and Treatment
- Genetic factors in colorectal cancer
- Nutritional Studies and Diet
- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Folate and B Vitamins Research
- Galectins and Cancer Biology
- Eosinophilic Esophagitis
- Esophageal and GI Pathology
- Gastrointestinal disorders and treatments
- Diet and metabolism studies
- Air Quality and Health Impacts
- Adipokines, Inflammation, and Metabolic Diseases
- Global Cancer Incidence and Screening
- Nutrition and Health in Aging
- Viral-associated cancers and disorders
- Cancer, Lipids, and Metabolism
- Obesity, Physical Activity, Diet
- Nuts composition and effects
- Cancer Risks and Factors
- Flavonoids in Medical Research
- Gut microbiota and health
Imperial College London
2022-2025
National Institutes of Health
2014-2024
National Cancer Institute
2014-2024
The London College
2024
Division of Cancer Epidemiology and Genetics
2012-2022
Centre International de Recherche sur le Cancer
2018
Tenwek Hospital
2016-2018
University of California, San Francisco
2018
Murphy Oil Corporation (United States)
2016
Duke University Hospital
2011-2015
Abstract Although incidence of colorectal cancer (CRC) in the United States has declined recent years, rates remain higher men than women and male‐to‐female rate ratio (MF IRR) increases progressively across colon from cecum to rectum. Rates among races/ethnicities other Whites or Blacks have not been frequently reported. To examine CRC by sex anatomic subsite, age racial/ethnic groups, we used National Cancer Institute's Surveillance, Epidemiology End Results (SEER) program for cases...
Meta-analyses of the published literature indicate that about 9% gastric cancers contain Epstein-Barr virus (EBV), with consistent and significant differences by sex anatomic subsite. This study aimed to identify additional determinants EBV positivity their joint effects.From 15 international populations laboratory testing for EBV, we pooled individual-level data 5081 cancer cases including information on age, sex, subsite, histologic type, diagnostic stage, geographic region, period...
Background: Lack of confidence in postpolypectomy surveillance guidelines may be a factor the observed low adherence rates among providers. Objective: To assess 2006 colonoscopy guidelines, which recommend 3-year follow-up for individuals with high-risk adenomas (defined as ≥3 or any advanced adenomas) and 5- to 10-year patients 2 fewer nonadvanced adenomas, who are considered at risk. Design: Analysis prospective data from Polyp Prevention Trial. Setting: United States. Participants: 1905...
Background: Historically, US women started smoking at a later age than men and had lower relative risks for smoking-related cancers. However, more recent birth cohorts of have similar histories now reached the high-risk cancer. The impact these changes on cancer incidence has not been systematically examined. Methods: Relative (RR), 95% confidence intervals (CI) attributable fractions were calculated cigarette 20 cancers in 186 057 266 074 National Institutes Health-AARP cohort, aged 50 to...
Incidence and mortality rates for gastric cancer, the fifth most commonly diagnosed third deadly cancer worldwide, are highest in East Asia. We sought to identify risk biomarkers among eight prospective studies from China, Japan Korea.This pooled nested case-control study included 1608 incident non-cardia cases 1958 matched controls. Pre-diagnostic antibody levels 15 Helicobacter pylori proteins were assessed using multiplex serology. Conditional logistic regression models used calculate...
Abstract The Polyp Prevention Trial (PPT) was a multicenter randomized clinical trial to evaluate the effects of high-fiber (18 g/1,000 kcal), high-fruit and -vegetable (3.5 servings/1,000 low-fat (20% total energy) diet on recurrence adenomatous polyps in large bowel over period 4 years. Although intervention participants reported significantly reduced intake dietary fat, increased fiber, fruit, vegetable intakes, their risk recurrent adenomas not different from that controls. Since PPT...
Helicobacter have been detected in human bile and hepatobiliary tissue. Despite evidence that species promote gallstone formation tumors laboratory studies, it remains unclear whether contribute to these cancers humans. We used a multiplex panel assess seropositivity 15 pylori proteins was associated with subsequent incidence of the Finnish Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study. included 64 biliary cancers, 122 liver 224 age-matched controls which occurred over...
Abstract Background: Macrophage inhibitory cytokine-1 (MIC-1/GDF15) mediates nonsteroidal anti-inflammatory drug (NSAID) protection from colonic polyps in mice and is linked to the development of colorectal carcinoma humans. Therefore, changes serum MIC-1/GDF15 levels could predict presence premalignant polyposis assist population screening strategies. Methods: Serum were measured subjects Polyp Prevention Trial, which NSAID use colon cancer risk factors defined. Subjects had an initial...
Previous studies have found associations between one-carbon metabolism nutrients and risk of several cancers, but little is known regarding upper gastrointestinal tract (UGI) cancer. We analyzed prediagnostic serum concentrations (vitamin B12, folate, vitamin B6, riboflavin homocysteine) in a nested case–control study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study male smokers, which was undertaken Finland 1985 1988. conducted including 127 noncardia gastric...
A beneficial effect of supplementation with selenium, vitamin E, and beta-carotene was observed on total cancer mortality in a Chinese population, it endured for 10 years postintervention, but longer durability is unknown. randomized, double-blind, placebo-controlled trial conducted Linxian, China, from 1986 to 1991; 29 584 residents age 40 69 received daily supplementations based factorial design: Factors (retinol/zinc), B (riboflavin/niacin), C (vitamin C/molybdenum), and/or D...
How carcinogen exposure varies across users of different, particularly noncigarette, tobacco products remains poorly understood.
Cancers of the upper gastrointestinal tract remain a substantial cause morbidity and mortality worldwide. Ghrelin is hormone produced in oxyntic glands stomach, under conditions chronic inflammation atrophy, serum ghrelin concentrations decrease. However, relationship between risk gastric esophagogastric junctional cancers has not been investigated.We conducted nested case-control study within Finnish Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study to examine concentration noncardia...
A 2012 Institute of Medicine report is the latest in growing number calls to incorporate a population health approach professionals' training. Over last decade, Duke University, particularly its Department Community and Family Medicine, has been heavily involved with community partners Durham, North Carolina, improve local community's health. On basis these initiatives, group interprofessional faculty began tackling need fill curriculum gap train future professionals public practice,...
<h3>Background</h3> Cancers of the upper gastrointestinal tract remain a significant cause morbidity and mortality. Cysteine, known to be involved in myriad immuno-modulatory, anti-oxidant, anti-carcinogenic pathways, has not been investigated aetiology oesophageal or gastric cancers. To examine relationship between serum cysteine concentration risk these cancers we conducted nested case–cohort study within General Population Nutrition Intervention Trial Linxian, China. <h3>Methods</h3> 498...
The reported associations with gastric adenocarcinoma and seropositivity to different Helicobacter pylori antigens using multiplex serology have not been consistent across studies. We aimed investigate the association between 15 risk of cardia (GCA) noncardia (GNCA) adenocarcinomas in northeastern Iran, a population high rates adenocarcinoma. included 272 cases (142 GCA, 103 GNCA, 27 unspecified) 524 controls who were individually matched for age, sex, place residence population-based...
Although previous studies have shown inverse associations between nut consumption and mortality, the less common causes of mortality not been investigated. Additionally, about 50% peanut in US is through butter but association has thoroughly evaluated. The National Institutes Health-AARP (NIH-AARP) Diet Health Study recruited 566,398 individuals aged 50–71 at baseline 1995–1996. A food-frequency questionnaire was used to evaluate consumption. Cox proportional hazard models were estimate...
Objective Colorectal cancer (CRC) screening enables resection of polyp precursor lesions, preventing or detecting it earlier. Post-polypectomy, people can remain at increased CRC risk, prompting surveillance colonoscopy. Less invasive faecal immunochemical tests (FIT) could reduce the burden We investigated whether changes in FIT values over multiple rounds were associated with advanced colorectal neoplasia (ACN) detection. Methods A cohort men and women aged 60–72 years deemed intermediate...