A5075899098- GDF15 and Related Biomarkers
- Macrophage Migration Inhibitory Factor
- Nutrition and Health in Aging
- Mitochondrial Function and Pathology
- Cardiac Ischemia and Reperfusion
- Metal complexes synthesis and properties
- Inorganic and Organometallic Chemistry
- ATP Synthase and ATPases Research
- Cardiac electrophysiology and arrhythmias
- Nuclear Receptors and Signaling
- Chemical Thermodynamics and Molecular Structure
- Hematological disorders and diagnostics
- Cancer Treatment and Pharmacology
- Organometallic Complex Synthesis and Catalysis
- Radiopharmaceutical Chemistry and Applications
- Tryptophan and brain disorders
- Peripheral Neuropathies and Disorders
- Medical Imaging Techniques and Applications
- Ion channel regulation and function
- Cancer Immunotherapy and Biomarkers
- Library Science and Administration
- Asymmetric Hydrogenation and Catalysis
- Multiple Sclerosis Research Studies
- Cardiac Arrest and Resuscitation
- Acute Myeloid Leukemia Research
The University of Sydney
1969-2025
Westmead Institute for Medical Research
2017-2025
New South Wales Department of Health
2018-2025
University of New Hampshire
2025
UNSW Sydney
2012-2024
Stealth BioTherapeutics (United States)
2020-2024
Westmead Hospital
2016-2024
Sydney Local Health District
2024
Alfred Health
2024
Westmead Institute
2018-2024
Genetic alterations in tumor cells often lead to the emergence of growth-stimulatory autocrine and paracrine signals, involving overexpression secreted peptide growth factors, cytokines, hormones. Increased levels these soluble proteins may be exploited for cancer diagnosis management or as points therapeutic intervention. Here, we combined use controlled vocabulary terms sequence-based algorithms predict genes encoding from among ≈12,500 sequences represented on oligonucleotide microarrays....
Here we identified growth-differentiation factor 15 (GDF15) (also known as MIC-1), a secreted member of the transforming growth (TGF)-beta superfamily, novel antihypertrophic regulatory in heart. GDF15 is not expressed normal adult heart but induced response to conditions that promote hypertrophy and dilated cardiomyopathy. To elucidate function heart, generated transgenic mice with cardiac-specific overexpression. were partially resistant pressure overload-induced hypertrophy. Expression...
Macrophage inhibitory cytokine-1 (MIC-1/GDF15) is a member of the TGF-b superfamily, previously studied in cancer and inflammation. In addition to regulating body weight, MIC-1/GDF15 may be used predict mortality and/or disease course cancer, cardiovascular (CVD), chronic renal heart failure, as well pulmonary embolism. These data suggested that marker all-cause mortality. To determine whether serum estimation predictor mortality, we examined cohort 876 male subjects aged 35-80 years,...
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) antibody neutralization response and its evasion by emerging viral variants variant of concern (VOC) are unknown, but critical to understand reinfection risk breakthrough infection following vaccination. Antibody immunoreactivity against SARS-CoV-2 antigens Spike variants, inhibition Spike-driven virus–cell fusion, infectious were characterized in 807 serial samples from 233 reverse transcription polymerase chain reaction...
Abstract Purpose: Patients with pancreatic ductal adenocarcinoma usually present advanced-stage disease and a dismal prognosis. One effective strategy likely to improve the morbidity mortality from cancer would be identification of accurate, noninvasive diagnostic markers that enable earlier diagnosis symptomatic patients detection in asymptomatic individuals at high risk for developing cancer. In this study, we evaluated serum macrophage inhibitory cytokine-1 (MIC-1) as marker Experimental...
Macrophage inhibitory cytokine-1 (MIC-1/GDF15) is associated with cardiovascular disease, inflammation, body weight regulation and cancer. Its serum levels facilitate the diagnosis prognosis of cancer vascular disease. Furthermore, its are a powerful predictor all-cause mortality, suggesting fundamental role in biological processes ageing. In cancer, data available suggest that MIC-1/GDF15 antitumorigenic, but this may not always be case as disease progresses. Cancer promoting effects due,...
More accurate serum markers of pancreatic cancer could improve the early detection and prognosis this deadly disease. We compared diagnostic utility a panel candidate cancer.We collected preoperative from 50 patients with resectable adenocarcinoma, as well sera chronic pancreatitis age/sex-matched healthy controls our institution. Sera were analyzed for following cancer: CA19-9, macrophage inhibitory cytokine 1 (MIC-1), osteopontin, tissue inhibitor metalloproteinase 1,...
Abstract Murine models of experimental autoimmune encephalomyelitis (EAE) are important vehicles for studying the effects genetic manipulation on disease processes related to multiple sclerosis (MS). Currently, a comprehensive assessment EAE pathogenesis with respect inflammatory and degenerating neuronal elements is lacking. By using Fluoro‐jade histochemistry mark neurodegeneration dual immunostaining follow T‐cell, microglial, vascular responses, time course distribution pathological...
Food intake and body weight are controlled by a variety of central peripheral factors, but the exact mechanisms behind these processes still not fully understood. Here we show that macrophage inhibitory cytokine-1 (MIC-1/GDF15), known to have anorexigenic effects particularly in cancer, provides protection against development obesity. Both under normal chow diet an obesogenic diet, transgenic overexpression MIC-1/GDF15 mice leads decreased fat mass. This lean phenotype was associated with...
The TGF-b superfamily cytokine MIC-1/GDF15 circulates in all humans and when overproduced cancer leads to anorexia/cachexia, by direct action on brain feeding centres. In these studies we have examined the role of physiologically relevant levels regulation appetite, body weight basal metabolic rate. gene knockout mice (MIC-1−/−) weighed more had increased adiposity, which was associated with spontaneous food intake. Female MIC-1−/− exhibited some additional alterations reduced energy...
Background Manifestations of reperfusion injury include myocyte death leading to infarction, contractile dysfunction, and vascular characterized by the “no‐reflow” phenomenon. Mitochondria‐produced reactive oxygen species are believed be centrally involved in each these aspects injury, although currently no therapies reduce targeting mitochondria specifically. Methods Results We investigated cardioprotective effects a mitochondria‐targeted peptide, Bendavia (Stealth Peptides), across...
High serum levels of macrophage inhibitory cytokine 1 (MIC-1) are strongly associated with metastatic prostate cancer, suggesting MIC-1 is a biomarker for cancer prognosis.We conducted prospective cohort study 1,442 Swedish men pathologically verified diagnosis between 2001 and 2003. Blood was drawn either pretreatment (n = 431) or posttreatment 1,011) cases were followed mean time 4.9 years (range, 0.1-6.8 years).MIC-1 independently predicted poor cancer-specific survival an almost 3-fold...