A5103007056- GDF15 and Related Biomarkers
- Cancer Immunotherapy and Biomarkers
- Macrophage Migration Inhibitory Factor
- Nuclear Receptors and Signaling
- Nutrition and Health in Aging
- Ferroptosis and cancer prognosis
- Genetic factors in colorectal cancer
- Colorectal Cancer Surgical Treatments
- Immunotherapy and Immune Responses
UNSW Sydney
2011-2013
St Vincent's Hospital
2011-2013
Macrophage inhibitory cytokine-1 (MIC-1/GDF15) is associated with cardiovascular disease, inflammation, body weight regulation and cancer. Its serum levels facilitate the diagnosis prognosis of cancer vascular disease. Furthermore, its are a powerful predictor all-cause mortality, suggesting fundamental role in biological processes ageing. In cancer, data available suggest that MIC-1/GDF15 antitumorigenic, but this may not always be case as disease progresses. Cancer promoting effects due,...
The TGF-b superfamily cytokine MIC-1/GDF15 circulates in all humans and when overproduced cancer leads to anorexia/cachexia, by direct action on brain feeding centres. In these studies we have examined the role of physiologically relevant levels regulation appetite, body weight basal metabolic rate. gene knockout mice (MIC-1−/−) weighed more had increased adiposity, which was associated with spontaneous food intake. Female MIC-1−/− exhibited some additional alterations reduced energy...
Lymph node metastasis indicates a poor prognosis in colorectal cancer. To better understand the underlying mechanisms of lymph metastasis, we analyzed transcriptome characteristics pre-metastatic node, putative microenvironment favorable for seeding and proliferation cancer cells. Thus, tried to compare elucidate transcriptional immune sentinel nodes (SNs) with matched non-sentinel (NSNs) patients. In this study, total 38 pairs SNs NSNs were collected, which 26 non-metastatic subjected...
Purpose. This study is aimed at immunologically characterizing sentinel lymph nodes (SNs) in colorectal cancer (CRC) patients and identifying changes immunological phenotype function of SNs isolated from the tumor immunosuppressive microenvironment. Methods. A total 53 pairs matched non-SNs (NSNs) were collected by using a node tracer dye. Flow cytometry was performed to detect immunophenotype T cells as well expression activation inhibitory markers. Differential distribution characteristic...