A5060234674- Vitamin C and Antioxidants Research
- Cancer, Lipids, and Metabolism
- Hematopoietic Stem Cell Transplantation
- Prostate Cancer Treatment and Research
- Cancer Genomics and Diagnostics
- PARP inhibition in cancer therapy
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- Ovarian cancer diagnosis and treatment
- Epigenetics and DNA Methylation
- Colorectal Cancer Treatments and Studies
- Prostate Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Head and Neck Cancer Studies
- Lymphoma Diagnosis and Treatment
- Economic and Financial Impacts of Cancer
- Polyomavirus and related diseases
- Immune Cell Function and Interaction
- Cancer-related Molecular Pathways
- Genetic factors in colorectal cancer
- Intraperitoneal and Appendiceal Malignancies
- Cancer-related gene regulation
- Esophageal Cancer Research and Treatment
- Neuroendocrine Tumor Research Advances
Johns Hopkins University
2016-2025
Sidney Kimmel Comprehensive Cancer Center
2016-2025
Johns Hopkins Medicine
2014-2025
Thomas Jefferson University
2024
University Hospitals Seidman Cancer Center
2024
Anne Arundel Medical Center
2024
University Hospitals of Cleveland
2024
The Barbara Ann Karmanos Cancer Institute
2009-2024
Wayne State University
2024
Sidney Kimmel Cancer Center
2011-2023
Antibodies that block programmed death 1 (PD-1) protein improve survival in patients with advanced non-small-cell lung cancer (NSCLC) but have not been tested resectable NSCLC, a condition which little progress has made during the past decade.In this pilot study, we administered two preoperative doses of PD-1 inhibitor nivolumab adults untreated, surgically early (stage I, II, or IIIA) NSCLC. Nivolumab (at dose 3 mg per kilogram body weight) was intravenously every 2 weeks, surgery planned...
Objective The authors reviewed the pathology, complications, and outcomes in a consecutive group of 650 patients undergoing pancreaticoduodenectomy 1990s. Summary Background Data Pancreaticoduodenectomy has been used increasingly recent years to resect variety malignant benign diseases pancreas periampullary region. Methods Between January 1990 July 1996, inclusive, underwent pancreaticoduodenal resection at Johns Hopkins Hospital. were recorded prospectively on all patients. All pathology...
The authors hypothesized that pancreaticogastrostomy is safer than pancreaticojejunostomy after pancreaticoduodenectomy and less likely to be associated with a postoperative pancreatic fistula.Pancreatic fistula leading cause of morbidity mortality pancreaticoduodenectomy, occurring in 10% 20% patients. Nonrandomized reports have suggested complications.Between May 1993 January 1995, the findings for 145 patients were analyzed this prospective trial at Johns Hopkins Hospital. After giving...
No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Feb 2003Biochemical (Prostate Specific Antigen) Recurrence Probability Following Radical Prostatectomy for Clinically Localized Prostate Cancer MISOP HAN, ALAN W. PARTIN, MARIANNA ZAHURAK, STEVEN PIANTADOSI, JONATHAN I. EPSTEIN, and PATRICK C. WALSH HANMISOP HAN , PARTINALAN PARTIN ZAHURAKMARIANNA ZAHURAK PIANTADOSISTEVEN PIANTADOSI EPSTEINJONATHAN EPSTEIN WALSHPATRICK View All Author...
Objective This study was designed to evaluate prospectively survival after pancreaticoduodenectomy for pancreatic adenocarcinoma, comparing two different postoperative adjuvant chemoradiation protocols those of no therapy. Summary Background Data Based on limited data from the Gastrointestinal Tumor Study Group, therapy has been recommended adenocarcinoma head, neck, or uncinate process pancreas. However, many patients continue receive such Methods From October 1991 through September 1995,...
Aberrant DNA methylation patterns may be the earliest somatic genome changes in prostate cancer. Using real-time methylation-specific PCR, we assessed extent of hypermethylation at 16 CpG islands from seven cancer cell lines (LNCaP, PC-3, DU-145, LAPC-4, CWR22Rv1, VCaP, and C42B), normal epithelial cells, stromal 73 primary cancers, 91 metastatic 25 noncancerous tissues. We found that GSTP1, APC, RASSF1a, PTGS2, MDR1 were hypermethylated >85% cancers but not cells tissues; EDNRB, ESR1,...
The Continual Reassessment Method (CRM) is a Bayesian phase I design whose purpose to estimate the maximum tolerated dose of drug that will be used in subsequent II and III studies. Its acceptance has been hindered by greater duration CRM designs compared standard methods, as well concerns with excessive experimentation at high dosage levels, more frequent severe toxicity. This paper presents results simulation study which one assigns than subject time each level, increase limited level. We...
<h3>Objective</h3> Recent data supports a significant role for immune checkpoint inhibitors in the treatment of solid tumours. Here, we evaluate gastric and gastro-oesophageal junction (G/GEJ) adenocarcinomas their expression programmed death-ligand 1 (PD-L1), infiltration by CD8+ T cells relationship both factors to patient survival. <h3>Design</h3> Thirty-four resections primary invasive G/GEJ were stained immunohistochemistry PD-L1 CD8 DNA situ hybridisation Epstein–Barr virus (EBV). cell...
PURPOSE In 1990 we published the results of an intensive 3-week preoperative chemoradiation regimen for locoregional esophageal cancer that suggested improved survival compared with historical controls. We now report long-term at a median follow-up 78.7 months. PATIENTS AND METHODS Forty-three patients squamous cell carcinoma or adenocarcinoma esophagus cardia were treated fluorouracil (5-FU), cisplatin, and bolus vinblastine concurrent radiation administered over 21 days. Transhiatal...
Regulatory T cells become resistant to cyclophosphamide after allogeneic stimulation, protecting against GVHD.
We conducted the first trial of neoadjuvant PD-1 blockade in resectable non-small cell lung cancer (NSCLC), finding nivolumab monotherapy to be safe and feasible with an encouraging rate pathologic response. Building on these results, promising data for plus ipilimumab (anti-CTLA-4) advanced NSCLC, we expanded our study include arm investigating ipilimumab.Patients stage IB (≥4 cm)-IIIA (American Joint Committee Cancer Tumor Node Metastases seventh edition), histologically confirmed,...
Neoadjuvant anti-PD-1 therapy has shown promise for resectable non-small cell lung cancer (NSCLC). We reported the first phase I/II trial of neoadjuvant nivolumab in NSCLC, finding it to be safe and feasible with encouraging major pathological responses (MPR). now present 5-year clinical outcomes from this trial, representing our knowledge, longest follow-up data any type.Two doses (3 mg/kg) were administered 4 weeks before surgery 21 patients Stage I-IIIA NSCLC. recurrence-free survival...
Human papillomavirus 16 (HPV-16) has been implicated as a causative agent in subset of head and neck squamous cell carcinomas (HNSCC). This study was undertaken to discern the distribution timing HPV viral integration during tumorigenesis upper respiratory tract.A tissue array assembled from consecutive group 176 patients with HNSCCs. The evaluated by HPV-16 situ hybridization p16 immunohistochemistry. Patients HPV-positive tonsillar cancers who had undergone bilateral tonsillectomies were...
Abstract Purpose: Patients with pancreatic ductal adenocarcinoma usually present advanced-stage disease and a dismal prognosis. One effective strategy likely to improve the morbidity mortality from cancer would be identification of accurate, noninvasive diagnostic markers that enable earlier diagnosis symptomatic patients detection in asymptomatic individuals at high risk for developing cancer. In this study, we evaluated serum macrophage inhibitory cytokine-1 (MIC-1) as marker Experimental...
The noninvasive identification of bladder tumors may improve disease control and prevent progression. Aberrant promoter methylation (i.e., hypermethylation) is a major mechanism for silencing tumor suppressor genes other cancer-associated in many human cancers, including cancer.A quantitative fluorogenic real-time polymerase chain reaction (PCR) assay was used to examine primary DNA urine sediment from 15 patients with cancer 25 subjects hypermethylation nine (APC, ARF, CDH1, GSTP1, MGMT,...
Abstract Objectives/Hypothesis: Clinical and molecular patterns of head neck squamous cell carcinoma (HNSCC) in nonsmokers smokers may be different. Analysis these improve understanding management this disease. Study Design: three hundred five subjects were included (46 nonsmokers, 29 former smokers, 230 smokers). Subsets analyzed for p53 mutation, human papillomavirus (HPV), loss heterozygosity (LOH) at 10 chromosomal loci. Methods: information was common disease among the groups. The gene...