A5040320882- HIV/AIDS Research and Interventions
- Adolescent Sexual and Reproductive Health
- HIV, Drug Use, Sexual Risk
- Reproductive tract infections research
- Sex work and related issues
- HIV Research and Treatment
- Intimate Partner and Family Violence
- Reproductive Health and Contraception
- Chronic Kidney Disease and Diabetes
- Gastric Cancer Management and Outcomes
- LGBTQ Health, Identity, and Policy
- Dialysis and Renal Disease Management
- Helicobacter pylori-related gastroenterology studies
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Global Maternal and Child Health
- HIV-related health complications and treatments
- Sarcoma Diagnosis and Treatment
- Focus Groups and Qualitative Methods
- Gastrointestinal Tumor Research and Treatment
- Health Policy Implementation Science
- Healthcare Policy and Management
- Neuroendocrine Tumor Research Advances
- Diabetes Treatment and Management
- Metastasis and carcinoma case studies
RTI International
2016-2025
University of California, San Francisco
2005-2025
University of Miami
2024
National Kidney Foundation
2019-2024
Inova Health System
2023
Kosair Children's Hospital
2023
San Francisco AIDS Foundation
2021
Johns Hopkins University
2000-2020
Columbia University
2020
University of the Witwatersrand
2020
(Abstracted from N Engl J Med 2016; DOI: 10.1056/NEJMoa1506110) The objective of this study was to examine the efficacy dapivirine vaginal rings in providing protection against human immunodeficiency virus type 1 (HIV-1). HIV-1 infection incidence is one highest sub-Saharan Africa.
In VOICE, a multisite HIV pre-exposure prophylaxis (PrEP) trial, plasma drug levels pointed to widespread product nonuse, despite high adherence estimated by self-reports and clinic counts. Using socio-ecological framework (SEF), we explored socio-cultural contextual factors that influenced participants' experience of daily vaginal gel oral tablet regimens in VOICE.In Johannesburg, qualitative ancillary study was concurrently conducted among randomly selected VOICE participants assigned...
Recognizing that race is a social and not biological construct, healthcare professionals the public have called for removal of in clinical algorithms. In response, National Kidney Foundation American Society Nephrology created Task Force on Reassessing Inclusion Race Diagnosing Diseases to examine issue provide recommendations. The final report from recommends calculating estimated glomerular filtration rate (eGFR) without coefficient using recently published CKD-EPI 2021 creatinine (cr)...
In Brief Background: Trichomonas vaginalis (T. vaginalis) is the most common nonviral sexually transmitted infection in world. Despite coexisting global epidemics of T. and HIV, little attention has focused on emerging evidence that increases susceptibility to, potentially transmission of, HIV. Methods: We evaluated context a multisite, randomized controlled trial amongst women South Africa Zimbabwe, to determine first, if risk HIV acquisition was increased among recently infected with...
Introduction Antiretroviral (ARV)‐based pre‐exposure prophylaxis (PrEP) is a promising new HIV prevention strategy. However, variable levels of adherence have yielded mixed results across several PrEP trials and populations. It not clear how taking ARV – traditionally used for treatment perceived that perception may affect the use these products as preventives. We explored views experiences VOICE participants, their male partners community members regarding in trial implications shared...
Background: The MTN-020/ASPIRE trial evaluated the safety and effectiveness of dapivirine vaginal ring for prevention HIV-1 infection among African women. A nested qualitative component was conducted at six 15 study sites in Uganda, Malawi, Zimbabwe South Africa to evaluate acceptability adherence ring. Method: Qualitative participants (n = 214) were interviewed with one three modalities: single in-depth interview, up serial interviews or an exit Focus Group Discussion. Using semistructured...
Background This was the first microbicide trial conducted in Africa to evaluate an antiretroviral-containing vaginal ring as HIV prevention technology for women. Objectives The assessed and compared safety, acceptability adherence product use of a 4-weekly administered containing antiretroviral microbicide, dapivirine, with matching placebo among women from four countries sub-Saharan Africa. Methods 280 Healthy, sexually active, HIV-negative women, aged 18 40 years were enrolled 140...
Abstract Introduction Existing biomedical HIV prevention options, though highly effective, present substantial adherence challenges. End‐user input on early‐stage design of new approaches is critical to yielding products that achieve high uptake and adherence. The iPrevent Study examined youths’ preferences for key attributes long‐acting Pre‐Exposure Prophylaxis (PrEP), with a focus characteristics pertinent product delivery alongside modifiable attributes. Methods A discrete choice...
An estimated 37 million Americans have chronic kidney disease (CKD). Nearly 90% do not know about their condition because of low awareness the importance CKD testing and diagnosis among practitioners people at risk for CKD. This study uses data from a national clinical laboratory to identify guideline-recommended rates across U.S.
In 2020, the National Kidney Foundation (NKF) and American Society of Nephrology (ASN) convened a Task Force to recommend an evidence-based race-free approach estimated glomerular filtration rate (eGFR). After rigorous review more than 20 approaches, NKF/ASN published final report that recommended implementation Chronic Disease Epidemiology Collaboration (CKD-EPI 2021) equation for eGFR using creatine expanded utilization cystatin C testing. The purpose this manuscript is provide...
Definitive histologic diagnosis of ulcerative colitis relies upon mucosal architectural distortion and inflammation in the appropriate clinical setting. Although crypt branching, atrophy, loss are usually present first biopsies from adults with colitis, it has been our impression that features chronicity often lacking children. To test this hypothesis, initial rectal follow-up and/or colonic resections 53 children (age 15 months to 17 years) 38 21-76 were examined a blinded fashion for...
In VOICE, a phase IIB trial of daily oral and vaginal tenofovir for HIV prevention, at least 50% women receiving active products had undetectable in all plasma samples tested. MTN-003D, an ancillary study using in-depth interviews (IDIs) focus group discussions (FGDs), together with retrospective disclosure pharmacokinetic results, explored adherence challenges during VOICE.We systematically recruited participants data (median six samples), categorized as low (0%, N = 79), inconsistent...
Adherence to HIV prevention methods is a challenge, particularly for young women in Sub-Saharan Africa. End-user research during product development can inform modifiable factors increase future uptake and adherence.Preferences four vaginally inserted placebo were assessed among Zimbabwean South African using crossover clinical design. For each of months 1 4, participants asked use pre-coitally film, insert (vaginal tablet) gel once/week month, monthly ring randomly assigned sequence....
Understanding the acceptability of long-acting injectable antiretroviral therapy (LAI-ART) among people with HIV (PWH), especially priority populations, is essential for effective implementation. We conducted semi-structured interviews patients in three Ryan White-funded clinics San Francisco, Chicago, and Atlanta. employed maximal variation sampling across age, gender, race, ethnicity, time living oversampled individuals suboptimal clinical engagement. An 8-step hybrid deductive inductive...
Enlisting male partner involvement is perceived as an important component of women's successful uptake female-initiated HIV prevention methods. We conducted a longitudinal study among cohort 955 Zimbabwean women participating in clinical trial the effectiveness method (the diaphragm and lubricant gel) to: (a) describe extent to which involved their partners decision use products, (b) measure effect support had on acceptability consistent these Reported levels discussions decisions regarding:...
Introduction Constructively engaging male partners in women‐centred health programs such as family planning and prevention of mother‐to‐child HIV transmission has resulted both improved outcomes stronger relationships. Concerted efforts to engage men microbicide use could make it easier for women access microbicides the future. This paper synthesizes findings from studies that investigated men's role their partners’ during clinical trials inform recommendations engagement women's use....