A5058929769- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Bacterial Identification and Susceptibility Testing
- Antibiotic Resistance in Bacteria
- Plant Pathogens and Fungal Diseases
- Antibiotic Use and Resistance
- Clinical Laboratory Practices and Quality Control
- Colorectal Cancer Screening and Detection
- SARS-CoV-2 and COVID-19 Research
- Global Cancer Incidence and Screening
- Electronic Health Records Systems
- Viral-associated cancers and disorders
- Statistical Methods in Clinical Trials
- SARS-CoV-2 detection and testing
- Healthcare Systems and Technology
- Yeasts and Rust Fungi Studies
- Reproductive tract infections research
- Enzyme Production and Characterization
- Polyomavirus and related diseases
- Lymphoma Diagnosis and Treatment
- Clostridium difficile and Clostridium perfringens research
- Innovations in Medical Education
- Diverticular Disease and Complications
- COVID-19 Clinical Research Studies
- Nosocomial Infections in ICU
Iowa City VA Health Care System
2015-2024
United States Department of Veterans Affairs
2023-2024
Veterans Health Administration
2008-2024
University of Iowa
2014-2024
University of Iowa Hospitals and Clinics
2013-2022
Iowa City VA Medical Center
2009-2021
UnityPoint Health
2021
VA Central Iowa Health Care System
2021
Biology of Infection
2018
Engineering Associates (United States)
2018
Recognizing that race is a social and not biological construct, healthcare professionals the public have called for removal of in clinical algorithms. In response, National Kidney Foundation American Society Nephrology created Task Force on Reassessing Inclusion Race Diagnosing Diseases to examine issue provide recommendations. The final report from recommends calculating estimated glomerular filtration rate (eGFR) without coefficient using recently published CKD-EPI 2021 creatinine (cr)...
ABSTRACT Diagnosis of Epstein-Barr virus (EBV) infection is based on clinical symptoms and serological markers, including the following: immunoglobulin G (IgG) IgM antibodies to viral capsid antigen (VCA), heterophile antibodies, IgG EBV early antigen-diffuse (EA-D) nuclear (EBNA-1). The use all five markers results in 32 possible patterns. As a result, interpretation serologies remains challenge. purpose this study was large population patients develop evidence-based tools for interpreting...
The opportunistic yeast Cryptococcus neoformans causes serious disease in humans and expresses a prominent polysaccharide capsule that is required for its virulence. Little known about how this synthesized. We previously identified beta1,2-xylosyltransferase (Cxt1p) with vitro enzymatic activity appropriate involvement synthesis. Here, we investigate C. strains which the corresponding gene has been deleted (cxt1Delta). Loss of CXT1 does not affect growth mutant cells or general morphology...
Cryptococcus neoformans is an opportunistic fungal pathogen characterized by a prominent polysaccharide capsule that envelops the cell. Although this dispensable for in vitro growth, its presence essential virulence. The primarily made of two xylose-containing polysaccharides, glucuronoxylomannan and galactoxylomannan. There are likely to be multiple xylosyltransferases (XTs) involved synthesis, activities these enzymes potentially important cryptococcal A β-1,2-xylosyltransferase with...
Abstract Purpose Distance from health care facilities can be a barrier to colorectal cancer (CRC) screening, especially for colonoscopy. Alternatively, an improved at‐home stool‐based screening tool, the fecal immunochemical test (FIT), requires only single sample and has better sensitivity‐specificity balance compared traditional guaiac occult blood tests. Our objective was determine if FITs mailed asymptomatic, average‐risk patients overdue resulted in higher rates versus mailing...
Aspergillus fumigatus is an environmental mold that causes severe, often fatal invasive infections in immunocompromised patients. The search for new antifungal drug targets critical, and the synthesis of cell wall represents a potential area to find such target. Embedded within main β-1,3-glucan core A. mixed linkage, β-D-(1,3;1,4)-glucan. role this molecule or how it synthesized unknown, though comprises 10% glucans wall. While not well-studied fungi, has been studied plants. Using...
ABSTRACT Currently, serological assays using either indirect immunofluorescence assay or enzyme-linked immunosorbent (ELISA) are performed to evaluate the status of Epstein-Barr virus (EBV) infection in humans. Although these methods reliable, they limited testing an antibody response a single viral antigen per reaction, thus necessitating panel complete evaluation. In contrast, new bead-based method (BioPlex 2200; Bio-Rad Laboratories, Hercules, Calif.) can analyze humoral multiple antigens...
ABSTRACT The filamentous fungus Aspergillus fumigatus is an important opportunistic pathogen that can cause high mortality levels in susceptible patient populations. increasing dependence on antifungal drugs to control A. has led the inevitable acquisition of drug-resistant forms this pathogen. In other fungal pathogens, drug resistance often associated with increase transcription genes such as ATP-binding cassette (ABC) transporters directly lead tolerance commonly employed drugs. , azole...
Ventilator-associated pneumonia (VAP) is a leading cause of health care-associated infection. It has high rate attributed mortality, and this mortality increased in patients who do not receive appropriate empirical antimicrobial therapy. As result the overuse broad-spectrum antimicrobials such as carbapenems, strains Acinetobacter, Enterobacteriaceae, Pseudomonas aeruginosa susceptible only to polymyxins tigecycline have emerged important causes VAP. The need accurately diagnose VAP so that...
Information continuity is critical to person-centered care when patients receive from multiple healthcare systems. Patients can access their electronic health record data through patient portals facilitate information exchange. This pilot was developed improve for rural Veterans by (1) promoting the use of Department Affairs (VA) portal share with non-VA providers, and (2) evaluating impact sharing at a community appointment.Veterans nine VA systems were trained Continuity Care Document...
Abstract Objectives Rectal and pharyngeal infections with gonorrhea chlamydia are of concern because they associated higher risk HIV acquisition. Extragenital screening in asymptomatic persons at high may have the potential to reduce incidence these sexually transmitted (STIs). Several testing platforms available for Chlamydia trachomatis (CT) Neisseria gonorrhoeae (NG) using nucleic acid amplification tests (NAATs). Self-collected extragenital samples currently not approved by US Food Drug...
Summary Consumer-mediated health information exchange (HIE) is one of the three types HIE designated by Office National Coordinator. intended to improve quality care while reducing cost, yet empirical support for this claim mixed. Future research should identify contexts whereby most effective. This study was conducted as a pilot two-arm randomized controlled trial. In intervention arm, 27 veterans were taught how generate Continuity Care Document (CCD) within Blue Button feature their VA...
The Manalpha1,3(Xylbeta1,2)Manalpha structural motif is common to both capsular polysaccharides of Cryptococcus neoformans and cryptococcal glycosphingolipids. Comparative analysis glycosphingolipid profiles in wild-type mutant strains showed that the Xylbeta1,2-transferase (Cxt1p) participates polysaccharide biosynthesis also sole transferase responsible for adding xylose C.
Histoplasmosis has a textbook cytologic description with numerous intracellular organisms that are readily apparent on routine stains. This is based series and reports describing histoplasmosis in immunosuppressed patients disseminated disease. With the advent of ultrasound-guided (US) fine-needle aspiration (FNA) techniques, marked increase diagnosis immunocompetent noted.A search identified all cytology cases diagnosed Histoplasma within past 10 years. Cases were reviewed, along patient...
Cryptococcus neoformans is a fungal pathogen that causes serious disease in immunocompromised individuals. The organism produces distinctive polysaccharide capsule necessary for its virulence, predominantly cell wall, and variety of protein- lipid-linked glycans. glycan synthetic pathways this are great interest. Here we report the detection novel glycosylphosphotransferase activity C. neoformans, identification corresponding gene, characterization encoded protein. observed specific...
Training in patient safety, quality, and management is widely recognized as an important element of graduate medical education. These concepts have been intertwined pathology education for many years, although training programs face challenges creating explicit learning opportunities these fields. Tangibly involving residents quality improvement projects has the potential to teach reinforce key further fulfill Accreditation Council Graduate Medical Education goals pursuing related safety...
<h3>Objective:</h3> The objective of this study was to determine what proportion veterans previously screened for colorectal cancer (CRC) using fecal immunochemical testing (FIT) would be willing undergo a second round FIT screening. <h3>Methods:</h3> Patients in the Iowa City Veterans Affairs Health Care System (<65 years old, asymptomatic, average risk, overdue CRC screening) who completed mailed (April 2011 May 2012) were contacted 1 year later by telephone collect demographic and...
All Accreditation Council for Graduate Medical Education accredited pathology residency training programs are now required to evaluate residents using the new Pathology Milestones assessment tool. Similar implementation of 6 competencies a decade ago, there have been challenges in milestones many programs. The department at University Iowa has implemented process that divides labor task rating while also maintaining consistency process. is described detail, and some initial trends milestone...
Blood culture contamination is a major problem in health care, with significant impacts on both patient safety and cost. Initiatives to reduce blood require reliable, consistent metric track the success of interventions. The objective our project was establish standardized definition suitable for use Veterans Health Administration (VHA) national data query, then validate this query. A secondary construct VHA dashboard display from query that could be used quality improvement projects aimed...
The Veterans Health Administration uses equity- and evidence-based principles to examine, correct, eliminate use of potentially biased clinical equations predictive models. We discuss the processes, successes, challenges, next steps in four examples. detail elimination race modifier for estimated kidney function achieve more equitable pulmonary testing measurement. equity lenses two modeling tools: Stratification Tool Opioid Risk Mitigation (STORM) Care Assessment Need (CAN) conclude with...