A5091507463- HIV/AIDS Research and Interventions
- Adolescent Sexual and Reproductive Health
- SARS-CoV-2 and COVID-19 Research
- HIV Research and Treatment
- HIV, Drug Use, Sexual Risk
- COVID-19 Clinical Research Studies
- Vaccine Coverage and Hesitancy
- Neonatal Respiratory Health Research
- Career Development and Diversity
- Reproductive tract infections research
- Social and Intergroup Psychology
- Sex work and related issues
- HIV-related health complications and treatments
- SARS-CoV-2 detection and testing
- HIV/AIDS drug development and treatment
- COVID-19 epidemiological studies
- Infant Development and Preterm Care
- Statistical Methods and Inference
- Neuroscience of respiration and sleep
- Bayesian Methods and Mixture Models
- Long-Term Effects of COVID-19
- Gender Diversity and Inequality
- Congenital Diaphragmatic Hernia Studies
- Hepatitis B Virus Studies
- Neonatal and fetal brain pathology
Fred Hutch Cancer Center
2016-2025
University of Washington
2015-2024
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2012-2024
Seattle University
2008-2023
National Institutes of Health
2007-2023
Edinburgh Cancer Research
2023
Western General Hospital
2023
University of North Florida
2015-2022
Cancer Research Center
2015-2022
Infectious Disease Research Institute
2016-2022
Although women have nearly attained equality with men in several formerly male-dominated fields, they remain underrepresented the fields of science, technology, engineering, and mathematics (STEM). We argue that one important reason for this discrepancy is STEM careers are perceived as less likely than other to fulfill communal goals (e.g., working or helping people). Such perceptions might disproportionately affect women's career decisions, because tend endorse more men. As predicted, we...
Although the three vaccines against coronavirus disease 2019 (Covid-19) that have received emergency use authorization in United States are highly effective, breakthrough infections occurring. Data needed on serial of homologous boosters (same as primary vaccine) and heterologous (different from fully vaccinated recipients.In this phase 1-2, open-label clinical trial conducted at 10 sites States, adults who had completed a Covid-19 vaccine regimen least 12 weeks earlier no reported history...
We hypothesize that the respiratory and functional states of very low birth weight infant with bronchopulmonary dysplasia can be improved in neonatal intensive care unit by prevention inappropriate sensory input. To test this hypothesis, we developed for preterm newborns a behavior observation method catalogues specific reaction patterns according to putative stress relaxation behaviors. then collected behavioral information heart rate, transcutaneous PO2 readings before, during, after...
The goal congruity perspective posits that 2 distinct social cognitions predict attraction to science, technology, engineering, or mathematics (STEM) fields. First, individuals may particularly value communal goals (e.g., working with helping others), due either chronic individual differences the salience of these in particular contexts. Second, hold beliefs about activities facilitate impede goals, affordance stereotypes. Women's tendency endorse more highly than do men, along consensual...
The optimal use of COVID-19 vaccine depends mainly on how efficacious the is and many doses are available.
(Abstracted from N Engl J Med 2016; DOI: 10.1056/NEJMoa1506110) The objective of this study was to examine the efficacy dapivirine vaginal rings in providing protection against human immunodeficiency virus type 1 (HIV-1). HIV-1 infection incidence is one highest sub-Saharan Africa.
Statistical experiments, more commonly referred to as Monte Carlo or simulation studies, are used study the behavior of statistical methods and measures under controlled situations. Whereas recent computing methodological advances have permitted increased efficiency in process, known variance reduction, such experiments remain limited by their finite nature hence subject uncertainty; when a is run than once, different results obtained. However, virtually no emphasis has been placed on...
Motivating students to pursue science careers is a top priority among many educators. We add the growing literature by examining impact of utility value intervention enhance student's perceptions that biomedical affords important work values. Using an expectancy-value perspective we identify and test two types value: communal (other-oriented) agentic (self-oriented). The culture replete with examples emphasizing high levels value, but values are often (stereotyped as) absent from science....
Significance Ever-growing empirical evidence documents a gender bias against women and their research—and favoring men—in science, technology, engineering, mathematics (STEM) fields. Our research examined how receptive the scientific public communities are to experimental demonstrating this bias, which may contribute women’s underrepresentation within STEM. Results from our three experiments, using general-public university faculty samples, demonstrated that men evaluate quality of unveiling...
<h3>Importance</h3> Preventive interventions are needed to protect residents and staff of skilled nursing assisted living facilities from COVID-19 during outbreaks in their facilities. Bamlanivimab, a neutralizing monoclonal antibody against SARS-CoV-2, may confer rapid protection SARS-CoV-2 infection COVID-19. <h3>Objective</h3> To determine the effect bamlanivimab on incidence among <h3>Design, Setting, Participants</h3> Randomized, double-blind, single-dose, phase 3 trial that enrolled 74...
The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibits reduced susceptibility to vaccine-induced neutralizing antibodies, requiring a boost generate protective immunity. We assess the magnitude and short-term durability antibodies after homologous heterologous boosting with mRNA Ad26.COV2.S vaccines. All prime-boost combinations substantially increase neutralization titers Omicron, although boosted decline rapidly within months from peak response...
BACKGROUND: Single-dose human papillomavirus (HPV) vaccination, if efficacious, would be tremendously advantageous, simplifying implementation and decreasing costs. METHODS: We performed a randomized, multicenter, double-blind, controlled trial of single-dose nonavalent (HPV 16/18/31/33/45/52/58/6/11 infection) or bivalent 16/18 HPV vaccination compared with meningococcal among Kenyan women 15 to 20 years age. Enrollment 6-monthly cervical swabs month 3 vaginal swab were tested for...
Easy-to-administer anti-SARS-CoV-2 treatments may be used to prevent progression from asymptomatic infection symptomatic disease and reduce viral carriage.
<h3>Importance</h3> The SARS-CoV-2 viral trajectory has not been well characterized in incident infections. These data are needed to inform natural history, prevention practices, and therapeutic development. <h3>Objective</h3> To characterize early RNA load (hereafter referred as load) individuals with infections association COVID-19 symptom onset severity. <h3>Design, Setting, Participants</h3> This prospective cohort study was a secondary analysis of remotely conducted that enrolled 829...
An experiment is reported in which the attribution of gender to isolated facial features and faces whose have been interchanged with those a face opposite has examined. Sixteen male were averaged create prototype sixteen female face. The prototypes then masked exclude ears, neck, hair, hairline. Individual (brows, eyes, nose, mouth, chin) pairs (brows & eyes nose mouth from presented isolation for classification according their perceived gender. results showed that, used, brows alone,...
OBJECTIVES. Phthalates are man-made chemicals found in personal care and other products. Recent studies suggest that some phthalates can alter human male reproductive development, but sources of infant exposure have not been well characterized. We investigated the relationship between phthalate metabolite concentrations urine maternal reported use dermally applied METHODS. measured 9 metabolites 163 infants who were born 2000–2005. An was considered to exposed any product mother using on her...
Summary This article proposes a new semiparametric Bayesian hierarchical model for the joint modeling of longitudinal and survival data. We relax distributional assumptions using Dirichlet process priors on parameters defining model. The resulting posterior distribution is free parametric constraints, in more robust estimates. type approach becoming increasingly essential many applications, such as HIV cancer vaccine trials, where patients' responses are highly diverse may not be easily...