A5063703285- Pediatric Urology and Nephrology Studies
- SARS-CoV-2 and COVID-19 Research
- Urinary Tract Infections Management
- Respiratory and Cough-Related Research
- Urological Disorders and Treatments
- Respiratory viral infections research
- Ear Surgery and Otitis Media
- COVID-19 Clinical Research Studies
- Kidney Stones and Urolithiasis Treatments
- Pneumonia and Respiratory Infections
- SARS-CoV-2 detection and testing
- Sinusitis and nasal conditions
- Neonatal Respiratory Health Research
- Methemoglobinemia and Tumor Lysis Syndrome
- Reservoir Engineering and Simulation Methods
- Syphilis Diagnosis and Treatment
- Neonatal Health and Biochemistry
- Oil and Gas Production Techniques
- Anesthesia and Sedative Agents
- COVID-19 and Mental Health
- Drug-Induced Ocular Toxicity
- Parvovirus B19 Infection Studies
- Diverticular Disease and Complications
- Birth, Development, and Health
- Infant Development and Preterm Care
University of Pittsburgh
2017-2025
Children's Hospital of Pittsburgh
2017-2025
University of Pittsburgh Medical Center
2018
The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibits reduced susceptibility to vaccine-induced neutralizing antibodies, requiring a boost generate protective immunity. We assess the magnitude and short-term durability antibodies after homologous heterologous boosting with mRNA Ad26.COV2.S vaccines. All prime-boost combinations substantially increase neutralization titers Omicron, although boosted decline rapidly within months from peak response...
Accurately estimating the probability of urinary tract infection (UTI) in febrile preverbal children is necessary to appropriately target testing and treatment.To develop test a calculator (UTICalc) that can first estimate UTI based on clinical variables then update laboratory results.Review electronic medical records aged 2 23 months who were brought emergency department Children's Hospital Pittsburgh, Pennsylvania. An independent training database comprising 1686 patients between January...
Importance The large overlap between symptoms of acute sinusitis and viral upper respiratory tract infection suggests that certain subgroups children being diagnosed with sinusitis, subsequently treated antibiotics, derive little benefit from antibiotic use. Objective To assess if therapy could be appropriately withheld in prespecified subgroups. Design, Setting, Participants Randomized clinical trial including 515 aged 2 to 11 years based on criteria. was conducted February 2016 April 2022...
As part of a multicenter study evaluating homologous and heterologous COVID-19 booster vaccines, we assessed the magnitude, breadth, short-term durability binding pseudovirus-neutralizing antibody (PsVNA) responses following single dose NVX-CoV2373 in adults primed with either Ad26.COV2.S, mRNA-1273, or BNT162b2 vaccines. as was immunogenic associated no safety concerns through Day 91. Fold-rises PsVNA titers from baseline (Day 1) to 29 were highest for prototypic D614G variant lowest more...
This study aimed to gather information about parental practices, knowledge, and attitudes regarding infant sleep habits environments, among families who practice non-recommended practices. We conducted one-on-one phone interviews with parents had practiced methods their or not experienced an undesirable event such as a fall. Interviews were recorded coded MAXQDA software. Intercoder reliability was assessed for consistency. Thirty-one consented, 21 conducted. Parents aware of current...
Amoxicillin-clavulanate (A/C) is currently the most effective oral antimicrobial in treating children with acute otitis media (AOM), but standard dosage of 90 mg amoxicillin/6.4 clavulanate/kg body weight/day commonly causes diarrhea. We examined whether an A/C formulation containing lower concentrations clavulanate would result less diarrhea while maintaining plasma levels amoxicillin and adequate to eradicate middle-ear pathogens achieve clinical success. conducted open-label study AOM who...
Abstract The Guando field is a late Cretaceous sandstone with two distinct reservoirs total gross thickness of approximately 1300 feet. Discovered in 2000, the Colombia's largest oil discovery since mid 1980's. Due to low initial reservoir pressure, water injection began almost simultaneously development. Water injected selectively into main reservoir's sands order optimize distribution water. However, recovery efficiency challenged by heterogeneity, including natural fractures. first...
Chylothorax is defined as the accumulation of chyle within pleural space. Originally described in 1917 by Pisek, it most common cause effusion neonatal period. The leading chylothorax laceration thoracic duct during surgery, which occurs 0.85% to 6.6% children undergoing cardiothoracic surgery. Few authors reports literature have looked at etilefrine, a relatively unknown sympathomimetic, an option for medical treatment chylothorax. In this case report, we review clinical course 2 infants...
Abstract Background The AAP recommends 7 to 14-days of antimicrobials for the treatment urinary tract infections (UTIs), one most common bacterial childhood. However, physicians routinely prescribe at least 10 days therapy. Prior observational studies suggest that courses shorter than might be effective. Methods primary objective was determine if halting antimicrobial therapy in children who improved clinically after 5 (short course therapy) results a similar failure rate as continue an...
Acute otitis media (AOM) is the most frequent reason for children to be prescribed antimicrobial treatment. Surfactants are naturally occurring substances that may restore eustachian tube's function and potentially enhance resolution of AOM.This was a phase 2a, single-center, double-blind, randomized, placebo-controlled, parallel group clinical trial assess safety, tolerability, efficacy 20 mg per day intranasal OP0201 as an adjunct therapy oral agents treating AOM in young children. We...
Paired nasopharynx and midturbinate swabs were obtained from 96 children (mean age: 2.45 years) with upper respiratory tract symptoms. Of these, 38.5% colonized Streptococcus pneumoniae only, 16.7% Haemophilus influenzae only 9.4% both bacteria. Bacterial cultures paired demonstrated agreement for S. (κ = 0.75), H. 0.59) pathogens 0.62). This report compares the results of bacterial specimens in infections.
Treatment of hepatitis C virus (HCV) during pregnancy can cure maternal HCV and prevent perinatal transmission. The primary objective was to compare the pharmacokinetics (PK) sofosbuvir/velpatasvir (SOF/VEL) in pregnant versus nonpregnant people.
An 8-month-old previously healthy Hispanic female was in her usual state of health until 3 weeks before admission, when she presented to a community clinic with irritability, dry cough, decreased oral intake, urine output, and fever. She diagnosed acute otitis media received 10 days amoxicillin-clavulanic acid azithromycin. The fever persisted despite antibiotic therapy, ranging from 38°C 39.4°C, developed maculopapular rash on head, face, trunk, extremities 5 admission. One day local...