A5019366387- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- Histone Deacetylase Inhibitors Research
- Acute Myeloid Leukemia Research
- Gene expression and cancer classification
- Statistical Methods and Bayesian Inference
- Statistical Methods and Inference
- Pancreatic and Hepatic Oncology Research
- Bioinformatics and Genomic Networks
- Ferroptosis and cancer prognosis
- Statistical Methods in Clinical Trials
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Glioma Diagnosis and Treatment
- Genomics and Chromatin Dynamics
- RNA modifications and cancer
- Advanced Breast Cancer Therapies
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Cell death mechanisms and regulation
- Genetic factors in colorectal cancer
- Multiple Myeloma Research and Treatments
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
The University of Texas at Austin
2019-2025
Livestrong Foundation
2019-2025
RWTH Aachen University
2009-2024
Sidney Kimmel Comprehensive Cancer Center
2004-2023
Emory University
2012-2021
Dell Children's Medical Center of Central Texas
2019-2020
Winship Cancer Institute
2012-2019
Georgia Department of Public Health
2014-2019
Piedmont Cancer Institute
2013-2017
Cancer Institute (WIA)
2013-2017
Aberrant DNA methylation patterns may be the earliest somatic genome changes in prostate cancer. Using real-time methylation-specific PCR, we assessed extent of hypermethylation at 16 CpG islands from seven cancer cell lines (LNCaP, PC-3, DU-145, LAPC-4, CWR22Rv1, VCaP, and C42B), normal epithelial cells, stromal 73 primary cancers, 91 metastatic 25 noncancerous tissues. We found that GSTP1, APC, RASSF1a, PTGS2, MDR1 were hypermethylated >85% cancers but not cells tissues; EDNRB, ESR1,...
Specific populations of highly tumorigenic cells are thought to exist in many human tumors, including pancreatic adenocarcinoma. However, the clinical significance these tumor-initiating (ie, cancer stem) remains unclear. Aldehyde dehydrogenase (ALDH) activity can identify and normal stem from several tissues. We examined prognostic functional features ALDH expression adenocarcinoma.ALDH was analyzed by immunohistochemistry 269 primary surgical specimens adenocarcinoma for association with...
Although some reports have found an association between increasing HLA disparity donor and recipient fewer relapses after allogeneic blood or marrow transplantation (BMT), this potential benefit has been offset by more graft-versus-host disease (GVHD) nonrelapse mortality (NRM). However, the type of GVHD prophylaxis might influence balance toxicity relapse. The present study analyzed impact greater on outcomes a specific platform for nonmyeloablative (NMA), HLA-haploidentical...
Abstract Advanced prostate cancer (PCa) often develops bone metastasis, for which therapies are very limited and the underlying mechanisms poorly understood. We report that bone-borne TGF-β induces acetylation of transcription factor KLF5 in PCa metastases, acetylated (Ac-KLF5) causes osteoclastogenesis metastatic lesions by activating CXCR4, leads to IL-11 secretion, stimulating SHH/IL-6 paracrine signaling. While essential maintaining mesenchymal phenotype tumorigenicity, Ac-KLF5 also...
The human papillomavirus (HPV) has been identified as a causative factor in 20% to 25% of all head and neck squamous cell carcinomas (HNSCC). Ongoing research suggests that the presence HPV DNA HNSCC predicts positive prognosis with respect disease-free overall survival. However, most studies have limited by heterogeneity treatment regimens and/or anatomic subsites tumor origin. In this study, we correlate clinical outcomes status for patients oropharyngeal who were uniformly treated...
BACKGROUND Mixed lineage kinase domain‐like protein (MLKL) is a necrosome component mediating programmed necrosis that may be an important determinant of cancer cell death. The goal the current study was to evaluate prognostic value MLKL expression in patients with pancreatic adenocarcinoma (PAC). METHODS Tissue from 80 collected prospectively maintained database PAC who underwent pancreaticoduodenectomy between January 2000 and October 2008. Immunohistochemistry analysis performed scored...
Abstract Phenotypic heterogeneity is widely observed in cancer cell populations. Here, to probe this heterogeneity, we developed an image-guided genomics technique termed spatiotemporal genomic and cellular analysis (SaGA) that allows for precise selection amplification of living rare cells. SaGA was used on collectively invading 3D packs create purified leader follower lines. The cultures are phenotypically stable highly invasive contrast cultures, which show phenotypic plasticity over time...
The human CD34(+)/CD38(-)/Lin(-) cell subset, comprising approximately 1-10% of the CD34(+) population, contains few less primitive hematopoietic (lineage-committed) progenitor cells (HPCs) but most in vivo engrafting (lympho-)hematopoietic stem (HSCs). We analyzed gene expression populations isolated from normal adult donor bone marrow, neonatal placental/umbilical cord blood, and mobilized peripheral blood stem-progenitor cells. As measured by Affymetrix microarrays, 4746 genes were...
Abstract Although previous studies have established a prominent role for HMGA1 (formerly HMG-I/Y) in aggressive human cancers, the of HMGA2 HMGI-C) malignant transformation has not been clearly defined. The HMGA gene family includes HMGA1, which encodes HMGA1a and HMGA1b protein isoforms, HMGA2, HMGA2. These chromatin-binding proteins function transcriptional regulation recent also suggest cellular senescence. appear to participate cell cycle transformation, whereas implicated primarily...
Background: The management of patients with thyroid fine-needle aspiration (FNA) specimens that are neither benign nor malignant still remains problematic. Efforts to improve their have focused on identifying risk factors predict malignancy. This study seeks identify clinical and tumor characteristics malignancy among indeterminate or suspicious FNA develop a diagnostic predictor model. Methods: records 639 an between January 1995 April 2005 were reviewed. Patient evaluated for potential in...
It is believed that patients who undergo thyroidectomy for Graves' disease are more likely to experience postoperative hypocalcemia than undergoing total other indications. However, no study has directly compared these two groups of patients. The aim this was determine whether there an increased incidence or severity in underwent disease.An institutional review board-approved database created all from 1998 2009 at the Johns Hopkins Hospital. There were a 68 with surgery. Fifty-five randomly...
Abstract Although HMGA1 (high-mobility group A1; formerly HMG-I/Y) is an oncogene that widely overexpressed in aggressive cancers, the molecular mechanisms underlying transformation by are only beginning to emerge. encodes HMGA1a and HMGA1b protein isoforms, which function regulating gene expression. To determine how leads neoplastic transformation, we looked for genes regulated using expression profile analysis. Here, show STAT3 gene, signaling molecule signal transducer activator of...
Chronic myeloid leukemia (CML) can be responsive to T-cell-mediated immunity. K562/granulocyte macrophage-colony stimulating factor (GM-CSF) is a GM-CSF producing vaccine derived from CML cell line that expresses several CML-associated antigens. A pilot study was developed determine if K562/GM-CSF immunotherapy could improve clinical responses imatinib mesylate (IM) in patients with chronic leukemia.Patients phase who achieved at least major cytogeneic response but remained persistent,...