A5088835990- Minimally Invasive Surgical Techniques
- Surgical Simulation and Training
- Abdominal Surgery and Complications
- Gallbladder and Bile Duct Disorders
- Thyroid Cancer Diagnosis and Treatment
- Hernia repair and management
- Esophageal and GI Pathology
- Cardiac, Anesthesia and Surgical Outcomes
- Intestinal and Peritoneal Adhesions
- Inflammatory Bowel Disease
- Appendicitis Diagnosis and Management
- Anatomy and Medical Technology
- Gastroesophageal reflux and treatments
- Abdominal Trauma and Injuries
- Nutrition, Genetics, and Disease
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Diverticular Disease and Complications
- Colorectal Cancer Surgical Treatments
- Hemodynamic Monitoring and Therapy
- Inflammasome and immune disorders
- Musculoskeletal pain and rehabilitation
- Thyroid and Parathyroid Surgery
- Autoimmune and Inflammatory Disorders
- Eosinophilic Esophagitis
Johns Hopkins Medicine
2009-2023
Johns Hopkins University
2012-2023
University of North Carolina at Chapel Hill
2017
Johns Hopkins Hospital
2006-2015
University of Chicago
2011
Université Paris Cité
2008-2010
Assistance Publique – Hôpitaux de Paris
2008-2010
Mercy Medical Center
2008-2010
University of Toronto
2010
Archéologie des Amériques
2009
Objective This study provides the first objective assessment of a complete patient population undergoing laparoscopic cholecystectomy in steady state. The authors determined frequency complications, particularly bile duct, bowel, vascular injuries, and deaths. Summary Background Data retrospective study, conducted for Department Defense healthcare system by Civilian External Peer Review Program, is second audit cholecystectomy. were collected on 9130 patients between January 1993 May 1994....
Crohn's disease (CD) and ulcerative colitis (UC) result from pathophysiologically distinct dysregulated immune responses, as evidenced by the preponderance of differing cell mediators circulating cytokine expression profiles. MicroRNAs (miRNAs) are small, noncoding RNAs that act negative regulators gene have an increasingly recognized role in regulation. We hypothesized differences cells CD UC patients reflected altered miRNA patterns can distinguish normal healthy individuals.Peripheral...
NLRP3 inflammasome is known to be involved in inflammatory bowel diseases. However, it controversial whether pathogenic or beneficial. This study evaluated the roles of pathogenesis disease IL-10-/- mice and humans. colonic mucosa, macrophages, epithelial cells were analysed by western blotting. The components studied sucrose density gradient fractionation, chemical cross-linking, co-immunoprecipitation. role NLPR3 colitis was extensively mice, using a specific inhibitor glyburide....
Laparoscopic repair of paraesophageal hernia (PEH) has been shown to result in excellent relief symptoms and improved quality life (QOL) despite a relatively high radiographically identified recurrence rate.To assess potential risk factors for long-term change QOL after laparoscopic PEH.This was prospective study 111 patients who underwent elective type III PEH with biological mesh buttressed over primary cruroplasty from April 3, 2009, through July 31, 2014, at the Department Surgery, Johns...
Background: The management of patients with thyroid fine-needle aspiration (FNA) specimens that are neither benign nor malignant still remains problematic. Efforts to improve their have focused on identifying risk factors predict malignancy. This study seeks identify clinical and tumor characteristics malignancy among indeterminate or suspicious FNA develop a diagnostic predictor model. Methods: records 639 an between January 1995 April 2005 were reviewed. Patient evaluated for potential in...
Abstract Purpose: Although fine-needle aspiration biopsy is the most useful diagnostic tool in evaluating a thyroid nodule, preoperative diagnosis of nodules frequently imprecise, with up to 30% cytology samples reported as “suspicious” or “indeterminate.” Therefore, other adjuncts, such molecular-based approaches are needed distinction these lesions. Experimental Design: In an attempt identify markers for lesions, we chose study by microarray analysis eight different tumor subtypes that can...
Reliable closure of the transluminal incision is crucial step for natural orifice endoscopic surgery (NOTES) procedures. The aim this study was to evaluate feasibility and effectiveness transgastric access with a flexible stapling device in porcine survival model.We carried out four experiments (two sterile two nonsterile) on 50 kg pigs. endoscope passed through gastrotomy made needle knife an 18-mm controlled radial expansion dilating balloon. After peritoneoscopy, linear (NOLC60, Power...
DNA hypermethylation is a common epigenetic abnormality in colorectal cancers (CRCs) and promising class of CRC screening biomarkers. We conducted genome-wide search for novel neoplasia-specific events the colon. applied methylation microarray analysis to identify loci hypermethylated 17 primary CRCs relative eight non-neoplastic colonic mucosae (NCs) from neoplasia-free subjects. These CRC-associated were then individually evaluated their ability discriminate neoplastic cases, based on...
Objective This study provided an objective survey by outside auditing group of a large, complete patient population undergoing laparoscopic cholecystectomies, determined the frequency complications, especially bile duct injuries, and presented system for classifying comparing severity injuries. Summary Background Data is first cholecystectomy to encompass large be based on objectively collected data rather than self-reported data. The Civilian External Peer Review Program (CEPRP) Department...
Recent gene-profiling analyses showed significant upregulation of the folate hydrolase (FOLH1) gene in affected intestinal mucosa patients with inflammatory bowel disease (IBD). The FOLH1 encodes a type II transmembrane glycoprotein termed glutamate carboxypeptidase (GCPII). To establish that previously reported increased expression was functional, we quantified enzymatic activity 31 surgical specimens and report robust 2.8- to 41-fold increase IBD compared an uninvolved area same or from...