A5066347765- Perovskite Materials and Applications
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Esophageal Cancer Research and Treatment
- Sphingolipid Metabolism and Signaling
- RNA modifications and cancer
- Quantum Dots Synthesis And Properties
- Gut microbiota and health
- Protein Tyrosine Phosphatases
- Multiferroics and related materials
- Microbial bioremediation and biosurfactants
- Galectins and Cancer Biology
- Cancer Cells and Metastasis
- Enzyme Structure and Function
- Organic Light-Emitting Diodes Research
- Endoplasmic Reticulum Stress and Disease
- Organic Electronics and Photovoltaics
- Biochemical and Structural Characterization
- Peptidase Inhibition and Analysis
- Enzyme Production and Characterization
- Natural product bioactivities and synthesis
- Ferroelectric and Piezoelectric Materials
- Hepatitis C virus research
- Conducting polymers and applications
Qiqihar University
2025
University of Saskatchewan
2015-2024
Capital Medical University
2024
Nanjing University of Posts and Telecommunications
2014-2024
Cornell University
2010-2024
Nanjing Institute of Technology
2022-2024
Beijing Anding Hospital
2024
China Electronics Technology Group Corporation
2024
Aerospace Information Research Institute
2023
State Key Laboratory of Remote Sensing Science
2023
Point mutations of the NADP + -dependent isocitrate dehydrogenases 1 and 2 (IDH1 IDH2) occur early in pathogenesis gliomas. When mutated, IDH1 IDH2 gain ability to produce metabolite ( R )-2-hydroxyglutarate (2HG), but downstream effects mutant proteins or 2HG on cellular metabolism are unknown. We profiled >200 metabolites human oligodendroglioma (HOG) cells determine expression mutants. Levels amino acids, glutathione metabolites, choline derivatives, tricarboxylic acid (TCA) cycle...
The cancer stem cell (CSC) hypothesis has gained significant recognition as a descriptor of tumorigenesis. Additionally, tumor-associated macrophages (TAMs) are known to promote growth and metastasis breast cancer. However, it is not whether TAMs mediate tumorigenesis through regulation CSCs. Here, we report that CSC-like phenotypes in murine cells by upregulating their expression Sox-2. These were characterized increased Sox-2, Oct-4, Nanog, AbcG2, Sca-1 gene expression, addition...
Cholangiocarcinomas (CCAs) are aggressive cancers, with high mortality and poor survival rates. Only radical surgery offers patients some hope of cure; however, most not surgical candidates because late diagnosis secondary to relatively accuracy diagnostic means. MicroRNAs (miRs) involved in every cancer examined, but they have been evaluated primary CCA. In this study, miR arrays were performed on five CCAs normal bile duct specimens (NBDs). Several miRs dysregulated miR-21 was...
Abstract Esophageal adenocarcinoma risk in Barrett's esophagus (BE) is increased 30- to 125-fold versus the general population. Among all BE patients, however, neoplastic progression occurs only once per 200 patient-years. Molecular biomarkers are therefore needed risk-stratify patients for more efficient surveillance endoscopy and improve early detection of progression. We performed a retrospective, multicenter, double-blinded validation study eight prediction methylation biomarkers....
The aim of this study was to evaluate procalcitonin (PCT) diagnostic accuracy in discriminating gram-negative (GN) from gram-positive (GP) bloodstream infections and determining the relationship between PCT levels, infection sites, pathogen types.Clinical laboratory data were collected patients with blood culture (BC)-positive sepsis January 2014 December 2015. levels at different sites compared, as presence GN GP infection. A receiver operating characteristic (ROC) curve generated assess...
SHP-1 is a cytosolic protein-tyrosine phosphatase that behaves as negative regulator in eukaryotic cellular signaling pathways. To understand its regulatory mechanism, we have determined the crystal structure of C-terminal truncated human inactive conformation at 2.8-Å resolution and refined to crystallographic R-factor 24.0%. The three-dimensional shows ligand-free has an auto-inhibited conformation. Its N-SH2 domain blocks catalytic keeps enzyme conformation, which supports activity...
Background Gliomas frequently contain mutations in the cytoplasmic NADP+-dependent isocitrate dehydrogenase (IDH1) or mitochondrial (IDH2). Several different amino acid substitutions recur at either IDH1 R132 IDH2 R172 glioma patients. Genetic evidence indicates that these share a common gain of function, but it is unclear whether shared function dominant negative activity, neomorphic production (R)-2-hydroxyglutarate (2HG), both. Methodology/Principal Findings We show by coprecipitation...
Claudins are membrane proteins that play critical roles in tight junction (TJ) formation and function. Members of the claudin gene family have been demonstrated to be aberrantly regulated, participate pathogenesis various human cancers. In present study, we report claudin-11 (CLDN11) is silenced gastric cancer via hypermethylation its promoter region.Levels CLDN11 methylation mRNA expression were measured primary tissues, noncancerous mucosae, cell lines origin using quantitative...
A biobased poly(butylene 2,5-furan dicarboxylate) (PBF) is synthesized and blended with poly(lactic acid) (PLA). With only 5 wt % addition of PBF, the elongation at break PLA becomes 18.5 times more than before, while tensile modulus strength yield keep almost same. Morphological analysis based on scanning electron microscope pictures shows drastic shape deformation PBF dispersed phases from sphere to fibril. The ratio phase much larger that matrix, which caused by a possible...
The crystal structures of the protein-tyrosine phosphatase SHP-1 catalytic domain and complex it forms with substrate analogue tungstate have been determined refined to crystallographic <i>R</i> values 0.209 at 2.5 Å resolution 0.207 2.8 resolution, respectively. Despite low sequence similarity, shows high similarity in secondary tertiary other phosphatases (PTPs). In contrast conformational changes observed PTP1B <i>Yersinia</i> PTP, WPD loop (Trp<sup>419</sup>-Pro<sup>428</sup>) moves away...
Abstract Purpose: Our aim was to investigate whether and at what stage hypermethylation of the tachykinin-1 (TAC1) gene is associated with human esophageal neoplastic transformation. Experimental Design: TAC1 promoter examined by real-time methylation-specific PCR in 258 specimens 126 plasma samples from patients or tissues various stages evolution. Results: tissue showed highly discriminative receiver-operator characteristic curve profiles, clearly distinguishing squamous cell carcinoma...
BackgroundBarrett's esophagus predisposes to esophageal adenocarcinoma. However, the value of endoscopic surveillance in Barrett's has been debated because low incidence adenocarcinoma esophagus. Moreover, high inter-observer and sampling-dependent variation histologic staging dysplasia make clinical risk assessment problematic. In this study, we developed a 3-tiered stratification strategy, based on systematically selected epigenetic parameters, improve efficiency.Methods FindingsWe defined...
Tumor suppressors refer to a large group of molecules that are capable controlling cell division, promoting apoptosis, and suppressing metastasis. The loss function for tumor suppressor may lead cancer due uncontrolled division. Because their importance, extensive studies have been undertaken understand the different functional mechanisms suppressors. Here, we briefly review four major mechanisms, inhibition induction DNA damage repair, It is noteworthy some suppressors, such as p53, adopt...
DNA hypermethylation is a common epigenetic abnormality in colorectal cancers (CRCs) and promising class of CRC screening biomarkers. We conducted genome-wide search for novel neoplasia-specific events the colon. applied methylation microarray analysis to identify loci hypermethylated 17 primary CRCs relative eight non-neoplastic colonic mucosae (NCs) from neoplasia-free subjects. These CRC-associated were then individually evaluated their ability discriminate neoplastic cases, based on...
Bovine respiratory disease (BRD) is the most common infectious in dairy and beef cattle. It associated with significant morbidity mortality causes a huge economic loss each year. In western Canada, one-time injection of tulathromycin commonly used as metaphylactic procedure to reduce BRD incidence eliminate potential outbreak. With increased global concern on antibiotic usage products bacterial resistance antibiotics, it important develop novel strategy or decrease dosage antibiotics. this...
Methyllysine reading protein Spindlin 1 (SPIN1) plays a crucial role in histone post-translational modifications and serves as an effective target for the treatment of various malignant tumours. Although several inhibitors targeting SPIN1 expression have been identified, atomic-level interactions between remain unclear. In this study, six potential A366, EML631, MS31, MS8535, vinspinln, XY49-92B were selected molecular docking with SPIN1. Conformational changes induced by these inhibitors,...