A5089477844- Esophageal Cancer Research and Treatment
- Epigenetics and DNA Methylation
- Genetic factors in colorectal cancer
- Cancer-related gene regulation
- Gastric Cancer Management and Outcomes
- Cancer Cells and Metastasis
- Esophageal and GI Pathology
- TGF-β signaling in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Mobile Ad Hoc Networks
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Effects of Radiation Exposure
- Gene expression and cancer classification
- Electron Spin Resonance Studies
- Integrated Circuits and Semiconductor Failure Analysis
- Privacy-Preserving Technologies in Data
- Peer-to-Peer Network Technologies
- DNA and Nucleic Acid Chemistry
- Caching and Content Delivery
- Silicon and Solar Cell Technologies
Kansai Electric Power Hospital
2019-2025
Kansai Electric Power (Japan)
2019-2025
Toho University
2012-2024
Hoshi University
2009-2024
Ebara (Japan)
2009-2024
University of Maryland, Baltimore
2002-2023
Konica Minolta (United States)
2023
Kyoto University
2011-2020
Sumitomo Electric Industries (Japan)
2019
National Institutes for Quantum Science and Technology
2019
Parkinson's disease (PD) is a prevalent neurodegenerative disorder. Recent identification of genes linked to familial forms PD such as Parkin and PINK1 (PTEN-induced putative kinase 1) has revealed that ubiquitylation mitochondrial integrity are key factors in pathogenesis. However, the exact mechanism underlying functional interplay between Parkin-catalyzed PINK1-regulated quality control remains an enigma. In this study, we show rapidly constitutively degraded under steady-state conditions...
Caffeine is one of the most frequently ingested neuroactive compounds. All known mechanisms apoptosis induced by caffeine act through cell cycle modulation or p53 induction. It currently unknown whether caffeine-induced associated with other death mechanisms, such as autophagy. Herein we show that increases both levels microtubule-associated protein 1 light chain 3-II and number autophagosomes, use western blotting, electron microscopy immunocytochemistry techniques. Phosphorylated p70...
Abstract Esophageal adenocarcinoma risk in Barrett's esophagus (BE) is increased 30- to 125-fold versus the general population. Among all BE patients, however, neoplastic progression occurs only once per 200 patient-years. Molecular biomarkers are therefore needed risk-stratify patients for more efficient surveillance endoscopy and improve early detection of progression. We performed a retrospective, multicenter, double-blinded validation study eight prediction methylation biomarkers....
Over the last decade, DNA microarray technology has provided a great contribution to life sciences. The MicroArray Quality Control (MAQC) project demonstrated way analyze expression microarray. Recently, been utilized comprehensive microRNA profiling. Currently, several platforms of chips are commercially available. Thus, we compared repeatability and comparability five different (Agilent, Ambion, Exiqon, Invitrogen Toray) using 309 microRNAs probes, Taqman system 142 probes. This study that...
The importance of microRNAs (miRNAs) in human malignancies has been well recognized. Here, we report that the expression microRNA-210 (miR-210) is down-regulated esophageal squamous cell carcinoma and derived lines. Marked decreases level miR-210 were observed especially poorly differentiated carcinomas. We found inhibits cancer survival proliferation by inducing death cycle arrest G(1)/G(0) G(2)/M. Finally, identified fibroblast growth factor receptor-like 1 (FGFRL1) as a target...
Abstract Background Cancer cells undergo massive alterations to their DNA methylation patterns that result in aberrant gene expression and malignant phenotypes. However, the mechanisms underlie methylome changes are not well understood nor is genomic distribution of characterized. Results Here, we performed methylated immunoprecipitation combined with high-throughput sequencing (MeDIP-seq) obtain whole-genome profiles for eight human breast cancer cell (BCC) lines normal mammary epithelial...
Objective Hepatocellular carcinoma (HCC) is difficult to manage due the high frequency of post-surgical recurrence. Early detection HCC recurrence after liver resection important in making further therapeutic options, such as salvage transplantation. In this study, we utilized microRNA expression profiling assess risk resection. Methods We examined paired tumor and non-tumor tissues from 73 patients who satisfied Milan Criteria. constructed prediction models recurrence-free survival using...
Circulating cell-free DNA (cfDNA) has recently been recognized as a resource for biomarkers of cancer progression, treatment response, and drug resistance. However, few have demonstrated the usefulness cfDNA early detection cancer. Although aberrant methylation in reported more than decade, its diagnostic accuracy remains unsatisfactory screening. Thus, aim present study was to develop highly sensitive cfDNA-based system primary breast (BC) using epigenetic digital PCR technology....
This paper simultaneously addresses three limitations associated with conventional skeleton-based action recognition; skeleton detection and tracking errors, poor variety of the targeted actions, as well person-wise framewise recognition. A point cloud deep-learning paradigm is introduced to recognition, a unified framework along novel deep neural network architecture called Structured Keypoint Pooling proposed. The proposed method sparsely aggregates keypoint features in cascaded manner...
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by inhibiting translation and/or inducing degradation of target mRNAs, and they play important roles in a wide variety biological functions including cell differentiation, tumorigenesis, apoptosis metabolism. However, there is paucity information concerning the regulatory mechanism miRNA expression. Here we report identification growth factor-regulated miRNAs using PC12 line, an established model neuronal...
Objective Trastuzumab has been used for the treatment of HER2-positive breast cancer (BC). However, a subset BC patients exhibited resistance to trastuzumab therapy. Thus, clarifying molecular mechanism will be beneficial improve patients. In this study, we identified trastuzumab-responsive microRNAs that are involved in therapeutic effects trastuzumab. Methods and Results RNA samples were obtained from (SKBR3 BT474) HER2-negetive (MCF7 MDA-MB-231) cells with without 6 days. Next, conducted...
The hepatitis C virus (HCV) invariably shows wide heterogeneity in infected patients, referred to as a quasispecies population. Massive amounts of genetic information due the abundance HCV variants could be an obstacle evaluate viral detail.Using newly developed massive-parallel ultra-deep sequencing technique, we investigated 27 chronic patients receiving peg-interferon (IFN) α2b plus ribavirin therapy.Ultra-deep determined total more than 10 million nucleotides genome, corresponding mean...
Abstract miRNAs have important roles in regulating cancer stem cell (CSC) properties and are considered to be potential therapeutic targets. However, few studies focused on which specifically related colon CSCs. Here, a PCR-based miRNA profiling analysis of normal cells (NCSC) CSCs (EpCAM+/CD44+/CD66a−) identified regulate CSC properties. Interestingly, miRNA-137 (miR-137) expression was downregulated the compared with NCSCs, while doublecortin-like kinase 1 (DCLK1) mRNA highly expressed but...