A5072168969- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal Transplantation Outcomes and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver physiology and pathology
- Organ Donation and Transplantation
- Clinical Nutrition and Gastroenterology
- Pediatric Hepatobiliary Diseases and Treatments
- Nutrition and Health in Aging
- Pancreatic function and diabetes
- Gallbladder and Bile Duct Disorders
- Neuroendocrine Tumor Research Advances
- Transplantation: Methods and Outcomes
- Cancer Cells and Metastasis
- Hepatitis C virus research
- Pancreatitis Pathology and Treatment
- Hepatitis B Virus Studies
- Liver Diseases and Immunity
- Congenital Anomalies and Fetal Surgery
- Epigenetics and DNA Methylation
- Skin and Cellular Biology Research
- Lung Cancer Research Studies
Shiga University of Medical Science
1995-2025
Kyoto University
2015-2024
Kyoto University Hospital
2013-2022
Japan Cancer Society
2018-2022
Pitié-Salpêtrière Hospital
2021
Sorbonne Université
2021
Assistance Publique – Hôpitaux de Paris
2021
Hôpitaux Universitaires Henri-Mondor
2021
Shiga University
2021
Society of Nuclear Medicine and Molecular Imaging
2020
Background. Although living donor liver transplantation for small pediatric patients is increasingly accepted, its expansion to older/larger still in question because of the lack sufficient information on impact graft size mismatching. Methods. A total 276 cases transplantation, excluding ABO-incompatible, auxiliary, or secondary transplants, were reviewed from matching. Forty-three highly urgent receiving intensive care preoperatively. Cases categorized into five groups by...
The authors successfully performed a series of 33 living related liver transplantations (LRLT) on children (15 males and 18 females, ranging from 7 months to 15 years age) June 1990 May 1992, with the informed consent their parents approval Ethics Committee Kyoto University. Before operation, six required intensive care, another 14 were hospitalized, 13 homebound. Donors (12 paternal 21 maternal) selected solely recipients basis ABO blood group graft/recipient size matching determined by...
Hepatopulmonary syndrome (HPS) and portopulmonary hypertension (PortoPH) are pulmonary vascular consequences of advanced liver disease associated with significant mortality after orthotopic transplantation (OLT). Data from 10 transplant centers were collected 1996 to 2001 that characterized the outcome patients either HPS (n = 40) or PortoPH 66) referred for OLT. Key variables (PaO2 HPS, mean artery pressure [MPAP], resistance [PVR], cardiac output [CO] PortoPH) analyzed respect 3 definitive...
Skeletal muscle depletion, referred to as sarcopenia, predicts morbidity and mortality in patients undergoing digestive surgery. However, the impact on liver transplantation is unclear. The present study investigated of sarcopenia living donor (LDLT). Sarcopenia was assessed by a body composition analyzer 124 adult LDLT between February 2008 April 2012. correlation with other patient factors survival after were analyzed. median ratio preoperative skeletal mass 92% (range, 67-130%) standard...
The 3rd version of Clinical Practice Guidelines for Hepatocellular Carcinoma was revised by the Japan Society Hepatology, according to methodology evidence-based medicine, which published in October 2013 Japanese. Here, we briefly describe new or changed recommendations with a special reference two algorithms surveillance, diagnosis, and treatment.
Abstract Background Although some retrospective studies have suggested the value of adjuvant therapy, no recommended standard exists in bile duct cancer. The aim this study was to test hypothesis that gemcitabine chemotherapy would improve survival probability resected Methods This a randomized phase III trial. Patients with cancer were assigned randomly and observation groups, which balanced respect lymph node status, residual tumour status location. Gemcitabine given intravenously at dose...
Hepatocytes generated from human induced pluripotent stem cells (hiPSCs) are unprecedented resources for pharmaceuticals and cell therapy. However, the in vitro directed differentiation of into mature hepatocytes remains challenging. Little attention has so far been paid to variations among hiPSC lines terms their hepatic differentiation. In current study, we developed an improved protocol compared 28 originated various somatic derived using retroviruses, Sendai viruses, or episomal...
The aim of this study was to compare the long-term outcomes and perioperative laparoscopic liver resection (LLR) with those open (OLR) for hepatocellular carcinoma (HCC) between well-matched patient groups.Hepatocellular patients underwent primary 2000 2010, were collected from 31 participating institutions in Japan divided into LLR (n = 436) OLR 2969) groups. A one-to-one propensity case-matched analysis used covariates baseline characteristics, including tumor characteristics surgical...
Intramuscular fat accumulation has come to be associated with loss of muscle strength and function, one the components sarcopenia. However, impact preoperative quality skeletal on outcomes after living donor liver transplantation (LDLT) is unclear. The present study evaluated intramuscular adipose tissue content (IMAC) psoas mass index (PMI) in 200 adult patients undergoing LDLT at our institution between January 2008 October 2013. Correlations IMAC other factors, overall survival rates...
As of 31 December 2017, a total 9242 liver transplants have been carried out in 67 institutions Japan. There were 447 deceased donor (444 from heart‐beating donors and 3 non‐heart‐beating donors) 8795 living‐donor transplants. The annual 2017 was 416 (69 347 transplants). most frequent indication cholestatic disease, followed by neoplastic disease hepatocellular disease. In terms cirrhosis due to hepatitis C B decreased (13 8, respectively), whereas alcoholic markedly increased (32). Patient...
For the sake of donor safety in living liver transplantation (LDLT), left lobe is currently being used most often for graft. However, size mismatch has been a major obstacle an expansion indication LDLT to larger-size recipients, because graft not safe enough them.In 1998, using right was introduced and performed on 26 recipients overcome small-for-size problem. The lobe, which does include middle hepatic vein donor, used. Initially, basically defined as estimated volume/recipient body...
Background. Anatomical variations in right liver lobe are common. However, clinical implications and surgical management of these living donor transplantation have not been analyzed systematically. Methods. Surgical anatomy vascular biliary structures 120 grafts were reevaluated by reviewing the results preoperative (computerized tomography Doppler ultrasonography) intraoperative (cholangiography) imaging as well findings. The data relation to anatomical variations. Results. incidence...
Background. Some reported studies have indicated the possibility of immunosuppression withdrawal in cadaveric liver transplantation. The aim this study was to evaluate and feasibility weaning living donor transplant recipients from immunosuppression. Methods. From June 1990 October 1999, 63 patients were considered be weaned They consisted 26 electively 37 either forcibly or incidentally (nonelective weaning) due various causes but mainly infection. Regarding elective weaning, we gradually...
In order to clarify the risk of hepatitis B virus (HBV) transmission from core antibody-positive (HBcAb(+)) donors and evolve a new strategy counter such risk, we undertook retrospective (1990-1995) prospective (1995-1996) analysis our experience with living related liver transplantation involving HBcAb(+) donors.Between June 15, 1990, 30, 1995, individuals were not excluded as donor candidates at institutions. For 171 transplants, 16 HBcAb(+). Between July 1, 1996, generally candidates;...
In the present study, results of living donor liver transplantation (LDLT) for 125 hepatocellular carcinoma (HCC) patients were analyzed to determine optimal criteria exceeding Milan (MC) but still with predictably good outcomes. On basis pretransplant imaging studies, 70 met MC, and 55 did not. Patients who exceeded MC presented ≤10 tumors all ≤5 cm in diameter (n = 30) displayed 5-year recurrence rates (7.3%) similar those within (9.7%, P 0.8787). According multivariate analysis risk...
Several recent reports have shown that hepatitis B virus (HBV) could be frequently transmitted to the recipients from donors who antibodies core antigen (anti-HBc) through liver transplantation. We provide here molecular evidence of latent HBV infection accompanied with ongoing viral replication in tissue anti-HBc–positive healthy individuals. DNA was detectable 13 14 were positive for both anti-HBc and surface (anti-HBs), but none 3 anti-HBs alone. The detected genomes these subjects...
To prevent small-for-size syndrome in adult-to-adult living donor liver transplantation (A-LDLT), larger grafts (ie, right lobe grafts) have been selected many transplant centers. However, some centers are investigating the benefits of portal pressure modulation. Five hundred sixty-six A-LDLT procedures using or left were performed between 1998 and 2008. In 2006, we introduced intentional control, changed graft selection criteria to include a graft/recipient weight ratio >0.7% instead...
The bioavailability of structurally unrelated drugs is limited by active secretion via the multidrug resistance gene (MDR1) product P-glycoprotein (Pgp) from enterocyte into lumen as well intestinal metabolism cytochrome P450 IIIA4 (CYP3A4). In present study, we analyzed whether genetic polymorphism MDR1 had some influence on expression levels Pgp and CYP3A4 tacrolimus concentration/dose ratio over first postoperative days in recipients living-donor liver transplantation (LDLT). Genotyping...
CCAAT/enhancer-binding protein (C/EBP) homologous (CHOP) is a key component in endoplasmic reticulum (ER) stress-mediated apoptosis. The goal of the study was to investigate role CHOP cholestatic liver injury. Acute injury and fibrosis were assessed wild-type (WT) CHOP-deficient mice following bile duct ligation (BDL). In WT livers, BDL induced overexpression Bax, downstream target CHOP-mediated ER stress pathway. Liver attenuated CHOP-knockout mice. Expression levels alpha-smooth muscle...