A5064907037- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Neuroendocrine Tumor Research Advances
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Organ Transplantation Techniques and Outcomes
- Gastrointestinal disorders and treatments
- Liver physiology and pathology
- Renal and related cancers
- Pluripotent Stem Cells Research
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Cancer Research and Treatments
- Renal cell carcinoma treatment
- Diagnosis and treatment of tuberculosis
- Cardiovascular Function and Risk Factors
- Hemostasis and retained surgical items
- CRISPR and Genetic Engineering
- Esophageal and GI Pathology
- IgG4-Related and Inflammatory Diseases
- Abdominal Surgery and Complications
- Minimally Invasive Surgical Techniques
- Clinical Nutrition and Gastroenterology
Fukuoka University
2022-2025
Kokura Memorial Hospital
2022-2023
Fukuoka University Hospital
2023
Tokyo Women's Medical University
2015-2022
Osaka Hospital
2020
Osaka Red Cross Hospital
2020
Saitama Cancer Center
2018
Kyoto University
2009-2013
National Cancer Center Hospital East
2007-2008
Kobe City Medical Center General Hospital
2003
Hepatocytes generated from human induced pluripotent stem cells (hiPSCs) are unprecedented resources for pharmaceuticals and cell therapy. However, the in vitro directed differentiation of into mature hepatocytes remains challenging. Little attention has so far been paid to variations among hiPSC lines terms their hepatic differentiation. In current study, we developed an improved protocol compared 28 originated various somatic derived using retroviruses, Sendai viruses, or episomal...
This study aimed to evaluate the utility of extracellular volume (ECV) fraction for predicting wall-invasion patterns in advanced gallbladder carcinoma (GBCA). Patients who had surgically resected GBCA at a single institution were retrospectively evaluated. All patients underwent computed tomography (CT) before surgery. Based on pathological examinations, pattern was classified into two groups: infiltrative growth (IG, n = 19) and destructive (DG, 11). ECV map generated by inputting...
Background and purpose Laparoscopic liver resection (LLR) has recently gained popularity owing to advances in surgical techniques. Difficulties LLR may be influenced by anatomical factors. This study presents a comprehensive overview of performed using extended reality (XR) technology. Methods Six patients underwent wearing HoloLens2® XR (Microsoft Corporation, Redmond, Washington, United States) We dynamic contrast-enhanced CT scans before surgery used the data construct three-dimensional...
Introduction Although there are a number of benefits to using robotics in liver surgery over conventional open and laparoscopic approaches, parenchymal transection is still the most difficult aspect robotic resection (RLR) due limitations currently available instruments lack standardized method. Methods We present novel method for transecting parenchyma during RLR employing saline-linked monopolar cautery (SLiC) scissors (SLiC-Scissors method). Between September 2021 April 2022, 10 RLRs were...
Background Without satisfactory instruments, liver parenchymal transection during robotic resection (RLR) remains challenging. We combined the commonly used bipolar clamp-crush technique with saline drip, achieving a comfortable without coagulated tissues sticking to forceps. Methods Between December 2022 and March 2023, six RLRs were performed using saline-linked method for both anatomical non-anatomical resections. assessed safety feasibility of our technique. Results Three patients...
Objective. With an increase in autoimmune pancreatitis (AIP) being reported, the focal type of AIP, which shows localized narrowing main pancreatic duct and swelling pancreas, has recently been recognized. Therefore, cases focal-type AIP subjected to surgical intervention for presumptive malignancy might previously have diagnosed as mass-forming chronic pancreatitis. The aim this study was elucidate incidence resected at a single tertiary cancer center. clinical radiological features were...
Hepatocyte transplantation utilizing induced pluripotent stem cells (iPSCs) or embryonic (ESCs) has been expected to provide an alternative liver transplantation. However, it remains uncertain precisely which cell type is the best suited for In particular, unclear whether mature hepatocytes, have sufficient function, immature hepatic progenitor cells, a higher proliferative capacity, will better outcome. The main objective of this study was investigate therapeutic efficacy hepatocytes at...
While minimizing intraoperative blood loss during liver resection is one of the most important tasks, it more difficult to control refractory bleeding laparoscopic than with an open approach. We herein provide a modification two-surgeon technique that enables parenchymal transection be performed as quickly and securely resection. To achieve proper "role sharing," "transection mode" "hemostatic are independent sets in place this procedure, these modes switched rigidly according surgical field...
Background: This study aims to clarify the perioperative risk factors and short-term prognosis of central bisectionectomy (CB) for hepatocellular carcinoma (HCC). Methods: Surgical data from 142 selected patients out 171 HCC who underwent anatomical CB (H458) between 2005 2020 were collected 17 expert institutions in a single-arm retrospective study. Results: Morbidities recorded by International Study Group Liver Surgery (ISGLS) grade BC post-hepatectomy liver failure (PHLF) bile leakage...
Background Although left hemihepatectomy has been widely performed via the laparoscopic approach, roles of assistant surgeon have not well-documented so far. We herein present our standardized procedures without Spiegel's lobe resection, focusing on crucial surgeon. Methods During countertraction by is quite important especially during isolating Glissonean pedicle and transecting liver parenchyma. When securing hepatic using pushes Segment 4 cranially pulls tape encircling hepatoduodenal...
Although laparoscopic hepatectomy has the potential advantage of reducing intraoperative blood loss, it is more difficult to control bleeding laparoscopically compared an open approach. We introduced a novel hemostatic technique, saline-linked electrocautery combined with wet oxidized cellulose (SLiC-WOC) method, during where combination (SLiC) and (WOC) used. This study aimed investigate feasibility employing SLiC-WOC method for hepatectomy.Thirteen patients who underwent liver resection...
症例は61歳,女性.貧血精査の上部内視鏡検査にて胃前庭部に圧排性病変を指摘された.造影CTにて胆嚢内を占拠する血流豊富な充実性病変を認めたが,明らかな漿膜および肝浸潤は認めなかった.胆嚢癌を疑い手術予定であったが,外来待機中に胆嚢炎を発症し,準緊急にて開腹拡大胆嚢摘出術および肝門部リンパ節郭清術を施行した.病理は広範な出血・壊死を伴う高異型度intracholecystic papillary neoplasm(ICPN)で,胆嚢管断端に腫瘍浸潤はなく,リンパ節転移も認めなかったため,追加切除や補助化学療法は施行しなかった.術後4カ月目,腹痛精査の造影CTにて腫瘍内出血を伴う多発肝転移を認めた.経カテーテル動脈塞栓術(以下TAEと略)にて状態が安定し,一旦退院としたが,TAEの1カ月後に再度腹痛をきたし,造影CTにて多発肝転移の増大と再度の腫瘍内出血を認めた.改めてTAEにて止血を行うも,その1カ月後(術後6カ月目)に癌死した.
症例は59歳男性で,心窩部痛を主訴に近医を受診し,膵頭部腫瘍の診断で紹介となった.腹部超音波で膵頭部に境界明瞭な径5 cm大の高エコー腫瘤を認め,内部に石灰化を伴っていたが,明らかな嚢胞成分は認めなかった.腫瘍は造影CTで遅延性の造影効果を示し,内部に変性を示唆する不染域を認めた.充実性のsolid-pseudopapillary tumor(SPT)あるいは乏血性の膵内分泌腫瘍の診断にて,亜全胃温存膵頭十二指腸切除術(SSpPD)を施行した.切除標本は被膜を有する白色調の充実性腫瘍で,内部に明らかな嚢胞成分は認めなかった.病理組織学的には腫瘍細胞は細血管周囲に偽乳頭状の増殖を示し,免疫染色にてchromogranin A(-),synaptophysin(-),CD10(+)であり,膵SPTと診断した.また核分裂像や静脈侵襲,神経周囲浸潤を認め,組織学的に悪性と考えられた.
ABSTRACT Background We have previously reported a saline‐linked bipolar clamp‐crush technique as novel robotic liver resection method. Herein, we present the surgical techniques and outcomes of left hepatectomy using Glissonean approach our transection technique. Methods The key procedures included following: (1) encircling pedicle Tip‐Up fenestrated grasper, (2) dissecting parenchyma technique, (3) moving endoscope one trocar to right facilitate visualisation plane, (4) stapling hepatic...
Abstract Aim Microvascular invasion (MVI) affects the prognosis and treatment of hepatocellular carcinoma (HCC); however, its preoperative diagnosis is challenging. Analysis computed tomography (CT) images using radiomics can detect MVI, but effectiveness depends on imaging conditions. We compared efficacies radiomics, clinical, combined models for predicting MVI in HCC nonstandardized scanning protocols. Methods This multicenter study included 533 patients who underwent hepatic resection...