A5085631531- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Gallbladder and Bile Duct Disorders
- Gastric Cancer Management and Outcomes
- Gastrointestinal disorders and treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Metastasis and carcinoma case studies
- Immunotherapy and Immune Responses
- Cancer Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Renal cell carcinoma treatment
- Liver physiology and pathology
- Pancreatic function and diabetes
- Metabolism and Genetic Disorders
- Neuroblastoma Research and Treatments
- Esophageal and GI Pathology
- Viral-associated cancers and disorders
- Organ Transplantation Techniques and Outcomes
- Glycosylation and Glycoproteins Research
- Cancer Genomics and Diagnostics
Tokai University
2015-2024
Tokai University Hospital
2015-2023
Tokyo Medical University
2022
National Cancer Center Hospital East
2003-2012
Shizuoka Cancer Center
2012
Aichi Cancer Center
2012
The Cancer Institute Hospital
2011
Juntendo University
2010
Teine Keijinkai Hospital
2010
Chiba University
1991-2003
The carcinoembryonic antigen glypican-3 (GPC3) is an ideal target of anticancer immunotherapy against hepatocellular carcinoma (HCC). In this nonrandomized, open-label, phase I clinical trial, we analyzed the safety and efficacy GPC3 peptide vaccination in patients with advanced HCC.Thirty-three HCC underwent (intradermal injections on days 1, 15, 29 dose escalation). primary endpoint was vaccination. secondary endpoints were immune response, as measured by IFN-γ ELISPOT assay, outcomes...
Objective: The aim of this study was to elucidate the clinicopathological features and prognosis mucinous cystic neoplasms (MCNs). Materials Methods: We performed a multi-institutional, retrospective on collected series patients with MCN pathologically defined by ovarian-type stroma. Clinicopathological were investigated. Result: Mucinous neoplasm confirmed in 156 cases, including 129 adenomas (82.7%) 21 noninvasive (13.4%) 6 invasive carcinomas (3.9%). Patients exclusively women (98.1%)...
Pancreatic ductal adenocarcinoma (PDAC) may derive from an intraductal papillary mucinous neoplasm (IPMN) of the pancreas or develop in pancreatic duct apart IPMN. The purpose this study was to define clinicopathological features these 2 entities and compare them with those ordinary PDAC.Of 765 patients who had surgical resection for IPMN, 122 were diagnosed as having PDAC derived IPMN 31 concomitant In addition, 7605 registered Japan Pancreas Society cancer registry compared above...
The relationship between overexpression of glypican (GPC)‐3 that is specific for hepatocellular carcinoma (HCC) and the prognosis has not yet been clarified. We attempted to determine expression profile GPC3 in association with clinicopathological factors by immunohistochemical analysis HCC patients investigated potential prognostic value comparing survival rate GPC3‐positive GPC3‐negative patients. Primary tissue samples ( n = 107) obtained from who had undergone hepatectomy 2000 2001 were...
Primary liver cancers are classified into three types based on their morphology and cytogenetic characteristics hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) combined (CHC). It is often difficult to distinguish these tumors. Glypican-3 (GPC3) serological histochemical marker of carcinoma. In order separate cancers, we analyzed the GPC3 expression in 85 resection specimens, including 46 HCCs, 28 ICCs 11 CHCs. immunohistochemical staining was used HCC from ICC by...
The prognosis of pancreatic carcinoma is generally very poor and difficult to predict. aim this study was quantitate with the onset symptoms.Survival curves clinicopathological findings 209 patients cancer admitted our hospital between 1992 1998 were retrospectively analyzed reference their symptoms (eg, abdominal pain, back jaundice, general fatigue, nausea) tumor location head, body, tail). interval from patient's first medical treatment laboratory data also reviewed. Univariate...
Nerve plexus invasion is regarded as one of the most important prognostic factors in invasive ductal carcinoma (IDC) pancreas, though nerve has not been evaluated terms impact on basis detailed histologic investigation. The purpose this study was to precisely examine morphologic characteristics and analyze its predictive power compared with well-known parameters pancreatic IDCs. outcome features 75 patients IDC pancreas head were investigated, 422 lesions evaluated. Tumor cells invading...
Glypican-3 (GPC3), a carcinoembryonic antigen, is an ideal target for anticancer immunotherapy against hepatocellular carcinoma (HCC). In this study, we attempted to compare the induction of GPC3-specific T-cell-mediated immune response after locoregional therapies in HCC patients and tumor-bearing mice. Twenty-seven treated with therapies, including radiofrequency ablation (RFA), surgical resection transcatheter arterial chemoembolization (TACE), were prospectively enrolled study....
We evaluated prognostic indicators for distal pancreatectomy with regional lymph node dissection in pancreatic body or tail carcinoma.Between 1993 and 2008, 50 patients ductal carcinoma of the pancreas who underwent were retrospectively analyzed. Clinicopathological factors associated patient survival evaluated.No in-hospital deaths occurred among study patients. The overall 5-year rate was 19.3%, median 22.6 months. Univariate analysis revealed that metastasis, intrapancreatic neural...
382 Background: Capecitabine is usually used for patients with curatively resected biliary tract cancer (BTC) in EU and US, but no clear survival benefit has been shown phase III trials. S-1, an oral fluoropyrimidine derivative, promising efficacy, a mild toxicity profile, advanced BTC. The aim of this trial was to confirm whether adjuvant S-1 therapy might improve the overall (OS) Methods: This open-label, multicenter, randomized conducted 38 Japanese hospitals. Eligible were aged 20 80...
Early recurrence is a major problem after hepatic resection of colorectal metastasis (CHM). Our aim was to investigate the relationship between time CHM and overall survival.A retrospective analysis performed for 101 consecutive patients who underwent have been followed more than 5 years.Among patients, 82 (81%) had recurrence. Overall survival with within 6 months significantly worse that (P < 0.01). poorer when shorter. One reasons poor prognosis only few could undergo second resection....
No consensus has been reached on the feasibility and efficacy of surgery for lymph node metastases (LNM) from hepatocellular carcinoma (HCC).Of 2189 patients with HCC treated at our hospital between July 1992 March 2008, we retrospectively reviewed medical dossiers 18 (0.8%) who underwent resection were pathologically diagnosed to have LNM HCC. The surgical procedure was selective lymphadenectomy those nodes suspected harbor metastasis. examined, clinicopathological factors analyzed aim...
Many investigators have examined prognostic factors for advanced pancreatic ductal cancer, but it is still difficult to accurately predict the outcome of disease.To examine correlation between histopathologic and carcinoma pancreas.The subjects were 23 patients who underwent resection cancer classified as stage III according pTNM classification. Fibrotic focus (which evidence intratumoral fibroblast proliferation), tumor size differentiation, invasion portal vein, immunohistologic expression...