A5038623087- Immunotherapy and Immune Responses
- Hepatocellular Carcinoma Treatment and Prognosis
- Global Cancer Incidence and Screening
- Hepatitis B Virus Studies
- Radiation Dose and Imaging
- Cancer Immunotherapy and Biomarkers
- Diet, Metabolism, and Disease
- Phytoestrogen effects and research
- Monoclonal and Polyclonal Antibodies Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Smoking Behavior and Cessation
- Effects of Radiation Exposure
- Nutritional Studies and Diet
- Diet and metabolism studies
- Dialysis and Renal Disease Management
- vaccines and immunoinformatics approaches
- Multiple and Secondary Primary Cancers
- Neonatal Health and Biochemistry
- Cancer Risks and Factors
- CAR-T cell therapy research
- Alcohol Consumption and Health Effects
- Eating Disorders and Behaviors
- Acute Lymphoblastic Leukemia research
- Carcinogens and Genotoxicity Assessment
- Advanced Neuroimaging Techniques and Applications
National Cancer Center Hospital East
2012-2025
Veterinary Medical Center
2022
Japan Medical Association
2021
Yokohama City University
2019
St. Luke's International Hospital
2019
Kyushu University Hospital
2019
Tokyo National Hospital
2019
Osaka City General Hospital
2019
University of Fukui
2019
Kanagawa Prefectural Hospital Organization
2019
The carcinoembryonic antigen glypican-3 (GPC3) is an ideal target of anticancer immunotherapy against hepatocellular carcinoma (HCC). In this nonrandomized, open-label, phase I clinical trial, we analyzed the safety and efficacy GPC3 peptide vaccination in patients with advanced HCC.Thirty-three HCC underwent (intradermal injections on days 1, 15, 29 dose escalation). primary endpoint was vaccination. secondary endpoints were immune response, as measured by IFN-γ ELISPOT assay, outcomes...
The recurrence rates of Hepatocellular carcinoma (HCC) are high, necessitating novel and effective adjuvant therapies. Therefore, we conducted a phase II study glypican-3 (GPC3) peptide vaccine as an therapy for HCC patients. Forty-one patients with initial who had undergone surgery or radiofrequency ablation (RFA) were analyzed in this II, open-label, single-arm trial. Ten vaccinations performed 1 y after curative treatment. We also investigated case-control subjects, where selected treated...
Abstract Objective To assess whether eldecalcitol, an active vitamin D analogue 2 , can reduce the development of type diabetes among adults with impaired glucose tolerance. Design Double blinded, multicentre, randomised, placebo controlled trial. Setting Three hospitals in Japan, between June 2013 and August 2019. Participants People aged 30 years older who had tolerance defined by using a 75 g oral test glycated haemoglobin level. Interventions were randomised to receive (eldecalcitol 0.75...
BackgroundObservational studies show inverse associations between serum 25-hydroxyvitamin D concentrations and sarcopenia incidence; however, it remains unclear whether treatment with vitamin prevents its development. We aimed to assess active (eldecalcitol [0·75 μg per day]) can reduce the development of among adults prediabetes.MethodsThis randomised, double-blind, placebo-controlled, multicenter trial as an ancillary study was conducted at 32 clinics hospital sites in Japan. Participants...
Determinants of prognosis after hepatic resection for metastasis from gastric cancer were studied in a retrospective series 21 patients, including four who survived more than 5 years surgery. All patients underwent apparently curative resection. Synchronous or metachronous resection, age, sex, histological type, depth invasion, lymphatic and venous lymph node involvement number metastases analysed as prognostic factors survival. Serosal invasion was the only significant determinant at...
Objectives: Equol, a metabolite of the isoflavone daidzein, is hypothesized to play major role in health benefits soy. We examined effect new S-equol supplement on menopausal symptoms and mood states. Design: conducted randomized, double-blind, placebo-controlled trial with our equol for 12 weeks 134 Japanese women (aged 40-59 years). They were randomly assigned three groups: placebo (n = 44), 10 mg per day (EQ-1; n times (EQ-3; 46). Habitual intake was limited 20 mg/d. Participants...
Background. The molecular genetic changes associated with colorectal carcinoma are among the best understood of any common human cancer. during late stages carcinomas may be useful in clinical management for determining metastatic potential carcinoma. Methods.Tumor tissues were evaluated by restriction fragment length polymorphism (RFLP) analysis chromosomes 5q, 17p, 18q, and 22q (n = 98), reverse transcription-polymerase chain reaction (RT-PCR) messenger RNA expression DCC gene (deleted...
We have previously conducted a phase I trial to test the efficacy of glypican-3 (GPC3) peptide vaccine in patients with advanced hepatocellular carcinoma (HCC); however, its immunological mechanism action remains unclear. Here, we report pilot study evaluate mechanisms this GPC3 (UMIN-CTR number 000005093). Eleven HCC were vaccinated trial. The primary end point was peptide-specific immune response induced by vaccination. secondary endpoints clinical and biologic outcomes. demonstrated that...
The carcinoembryonic antigen glypican-3 (GPC3) is a good target of anticancer immunotherapy against pediatric solid tumors expressing GPC3. In this non-randomized, open-label, phase I clinical trial, we analyzed the safety and efficacy GPC3-peptide vaccination in patients with tumors. Eighteen GPC3 underwent (intradermal injections every 2 weeks), primary endpoint being secondary endpoints immune response, as measured by interferon (IFN)-γ enzyme-linked immunospot assay Dextramer staining,...
To clarify mortality risks of oesophageal cancer associated with hot tea, alcohol, tobacco and diet, further analyses on the data from a large prospective cohort study in Japan were conducted. The subjects for analysis 220, 272 'men women aged 40 to 69 at baseline 1965. There 440 deaths during period January 1966 December 1981. Person-years risk 3, 065, 182 total. Rate ratio 95% confidence interval adjusted attained age, prefecture, occupation sex (RR (95%Cl)): 1.6 (1.2-2.0) tea (drinking...
To define surgically curable “early” adenocarcinoma in the periphery of lung, we examined histopathologic prognostic factors 56 cases stage I mucinous, non-mucinous, and sclerosing bronchioloalveolar carcinomas less than 2 cm diameter. The death rate 5 years after surgery was only 1.8%, but recurrence within 8.9%. In addition, there were two more surgery. Vascular invasion (p < 0.05) mitotic index 0.01) most important determinants prognosis, no or showing grades 1 collagenization fibrotic...
Cerebrovascular disease was a leading cause of death from 1955 to 1980 in Japan. The mortality rate this has decreased sharply recent decades. This downward trend seems correspond the dietary habits Japanese. Data large prospective cohort study were analyzed examine association between and cerebrovascular subjects for analysis 223, 170 men women aged 40 69 at baseline December 1965. There 6, 168 deaths 4, 862 due (ICD7: 330-334) during follow-up period January 1966 1981. Rate ratio (RR) 95%...
In the present study, an attempt was made to determine precise pharmacokinetics of 7‐ethyl‐10‐[4‐(1‐piperidino)‐1‐piperidino]carbonyloxycamptothecin (CPT‐11) and its active metabolite, 7‐ethyl‐10‐hydroxycamptothecin (SN‐38). The relationship between pharmacokinetic parameters pharmacodynamic effects also investigated elucidate cause interpatient variation in side effects. Thirty‐six patients entered study. CPT‐11, 100 mg/m 2 , administered by IV infusion over 90 min weekly for four...
Prostate cancer mortality age-standardized rates (ASRs; using 1985 Japanese standard population) are shown for Japan, USA, UK, France and Italy (Fig. 1).ASRs males were much lower compared to those observed among in the
Abstract Aims/Introduction To assess the impact of smoking on impaired insulin secretion and resistance in Japanese men. Materials Methods This study included 1,199 men aged 30–79 years without diabetes, at baseline who underwent a comprehensive medical check‐up between A pril 2006 M arch 2007 S aku C entral H ospital. Smoking status was categorized as current, ex‐smoker never‐smoker. Insulinogenic index homeostasis model assessment‐insulin were determined using standard 75‐g oral glucose...
The Great East Japan Earthquake of 2011 left many evacuees with insufficient food and emergency shelter. However, there is no evidence concerning the factors affecting dietary circumstances in shelters after disasters. To clarify that influenced provision meals, we reanalyzed a data set from survey conducted one month (2011). Among 69 "city A," 53 (79.1%) had shortages. possibility cooking shelter improved meals to evacuees. When comparing without equipment, equipment provided more as well...
There is no established postoperative adjuvant therapy for hepatocellular carcinoma (HCC), and improvement of patient prognosis has been limited. We conducted long-term monitoring patients within a phase II trial that targeted cancer antigen, glypican-3 (GPC3), specifically expressed in HCC. sought to determine if the GPC3 peptide vaccine was an effective by disease-free survival overall survival. also tracked immunohistochemical (IHC) staining, CTL induction, plasma group administered (n =...