A5022285016- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Nutrition and Health in Aging
- Cancer Genomics and Diagnostics
- Gallbladder and Bile Duct Disorders
- Cancer Immunotherapy and Biomarkers
- Liver Disease Diagnosis and Treatment
- MRI in cancer diagnosis
- Colorectal Cancer Treatments and Studies
- Frailty in Older Adults
- Esophageal and GI Pathology
- Peptidase Inhibition and Analysis
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Metastasis and carcinoma case studies
- Gastrointestinal disorders and treatments
- Body Composition Measurement Techniques
- Appendicitis Diagnosis and Management
- Neuroblastoma Research and Treatments
- Lung Cancer Diagnosis and Treatment
- Surgical site infection prevention
- Surgical Simulation and Training
National Cancer Center Hospital East
2015-2025
Nagaoka University
2024
Nagaoka University of Technology
2024
Eastern Hepatobiliary Surgery Hospital
2020
Second Military Medical University
2020
Mayo Clinic
2017-2019
WinnMed
2019
Mayo Clinic in Arizona
2018-2019
Center for Digestive and Liver Diseases
2018
UCLA Medical Center
2017
Purpose To develop and evaluate a fully automated algorithm for segmenting the abdomen from CT to quantify body composition. Materials Methods For this retrospective study, convolutional neural network based on U-Net architecture was trained perform abdominal segmentation data set of 2430 two-dimensional examinations tested 270 examinations. It further separate 2369 patients with hepatocellular carcinoma (HCC). were performed between 1997 2015. The mean age 67 years; male patients, it years...
Importance The effect of adjuvant chemotherapy following resection pancreatic adenocarcinoma after preoperative (m)FOLFIRINOX (combination leucovorin calcium [folinic acid], fluorouracil, irinotecan hydrochloride, and oxaliplatin in full or modified dosing) on overall survival (OS) is unclear because current studies do not account for the number cycles regimen. Objective To investigate association with OS, taking into Design, Setting, Participants This retrospective cohort study included...
Generally, cancer tissue is palpated as a hard mass. However, the elastic nature of not well understood. The aim present study was to evaluate clinical utility measuring modulus (EM) in colorectal tissue. Using tactile sensor, we measured EM 106 surgically resected tissues. Data on were compared with clinicopathological findings, including stromal features represented by Azan staining and α-SMA positive area ratio tumor area. Finally, cDNA microarray profile tumors high findings low EM. A...
Postoperative pancreatic fistula (POPF) is a major, intractable complication after distal pancreatectomy (DP). Risk factor evaluation and prevention of this are important tasks for surgeons.One hundred six patients who underwent DP using stapler division were retrospectively investigated. The relationship between clinicopathological factors the incidence POPF was statistically analyzed.Clinically relevant, Grade B or C by International Study Group Pancreatic Fistula criteria occurred in 52...
Importance Preoperative chemo(radio)therapy is increasingly used in patients with localized pancreatic adenocarcinoma, leading to pathological complete response (pCR) a small subset of patients. However, multicenter studies in-depth data about pCR are lacking. Objective To investigate the incidence, outcome, and risk factors after preoperative chemo(radio)therapy. Design, Setting, Participants This observational, international, cohort study assessed all consecutive pathology-proven...
We successfully determined the difference of immune microenvironments between pNENs and pancreatic ductal adenocarcinomas (PDACs), histology-dependent variability among using multispectral fluorescent imaging system. Tumour tissue samples including 52 18 PDACs were investigated. The tumour-infiltrating lymphocytes (TILs), their PD-1 PD-L1 expression in comprehensively quantitatively analysed subsequently compared with those PDACs. A principal component analysis revealed that profile is...
According to the 2012 International Consensus Guidelines, diagnostic criterion of intraductal papillary mucinous neoplasms (IPMNs) involving main duct (MD IPMNs) or and branch ducts (mixed pancreatic system is a (MPD) diameter 5.0 mm greater on computed tomography (CT) magnetic resonance imaging (MRI). However, surgical resection recommended for patients with an MPD 10.0 greater, which characterized as high-risk stigma. An 9.0 not indication immediate resection.To determine appropriate...
Abstract Background and Objectives Conclusive evidence in favor of neoadjuvant therapy for those with non‐metastatic pancreatic ductal adenocarcinoma (PDAC) is still lacking. The objective this study was to evaluate the survival benefit vs upfront surgery patients PDAC. Methods involved 565 undergoing or as primary treatment Propensity score matching performed between group (NAT group) (UFS using 20 clinical variables at diagnosis. Overall surgical pathology were compared two groups on an...
There is no established postoperative adjuvant therapy for hepatocellular carcinoma (HCC), and improvement of patient prognosis has been limited. We conducted long-term monitoring patients within a phase II trial that targeted cancer antigen, glypican-3 (GPC3), specifically expressed in HCC. sought to determine if the GPC3 peptide vaccine was an effective by disease-free survival overall survival. also tracked immunohistochemical (IHC) staining, CTL induction, plasma group administered (n =...
Pancreatic cancer is associated with development of cachexia, a wasting syndrome thought to limit survival. Few studies have longitudinally quantified peripheral tissues or identified biomarkers predictive future tissue wasting.Adipose and muscle were measured by computed tomography (CT) at diagnosis 50 120 days later in 164 patients advanced pancreatic cancer. Tissue changes survival evaluated Cox proportional hazards regression. Baseline levels circulating markers examined relation...
Despite previously reported treatment strategies for nonfunctioning small (≤20 mm) pancreatic neuroendocrine neoplasms (pNENs), uncertainties persist. We aimed to evaluate the surgically resected cases of pNENs (NF-spNENs) in a large Japanese cohort elucidate an optimal strategy NF-spNENs.
Abstract Sarcomatoid hepatocellular carcinoma (SHCC), which was a rare histological subtype of (HCC), is currently subclassified as poorly differentiated HCC because insufficient evidence to define SHCC HCC. We aimed assess the feasibility classifying by comprehensively identifying novel and distinct characteristics compared ordinary (OHCC). Fifteen SHCCs (1.4%) defined with at least 10% sarcomatous component, 15 randomly disease‐stage‐matched OHCCs 163 consecutive were extracted from 1106...