Minoru Tanabe
A5103204983- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Organ Transplantation Techniques and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroendocrine Tumor Research Advances
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Lung Cancer Research Studies
- Pancreatitis Pathology and Treatment
- Neuroblastoma Research and Treatments
- Renal Transplantation Outcomes and Treatments
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- Renal cell carcinoma treatment
- Cancer, Lipids, and Metabolism
- Pediatric Hepatobiliary Diseases and Treatments
- Gastrointestinal Tumor Research and Treatment
- Ferroptosis and cancer prognosis
- Liver physiology and pathology
- Epigenetics and DNA Methylation
- Hepatitis B Virus Studies
- Gastrointestinal disorders and treatments
- Radiomics and Machine Learning in Medical Imaging
- Clinical Nutrition and Gastroenterology
Tokyo Medical and Dental University
2016-2025
The University of Tokyo
2022-2024
Tokyo Medical and Dental University Hospital
2016-2022
Japan Cancer Society
2022
Second Military Medical University
2021
Weatherford College
2021
Eastern Hepatobiliary Surgery Hospital
2021
Keio University
2006-2017
The University of Texas MD Anderson Cancer Center
2017
Tokyo National Hospital
2017
Abstract Early on, laparoscopic liver resection ( LLR ) was limited to partial resection, but major is no longer rare. A difficulty scoring system required guide surgeons in advancing from simple highly technical resections. Subjects were 90 patients who had undergone pure at three medical institutions (30 patients/institution) J anuary 2011 pril 2014. Surgical assessed by the operator using an index of 1–10 with following divisions: 1–3 low difficulty, 4–6 intermediate and 7–10 high...
The aim of this study was to compare the long-term outcomes and perioperative laparoscopic liver resection (LLR) with those open (OLR) for hepatocellular carcinoma (HCC) between well-matched patient groups.Hepatocellular patients underwent primary 2000 2010, were collected from 31 participating institutions in Japan divided into LLR (n = 436) OLR 2969) groups. A one-to-one propensity case-matched analysis used covariates baseline characteristics, including tumor characteristics surgical...
BackgroundHepatocellular carcinoma (HCC) is a heterogeneous disease with various etiological factors, and ranks as the second leading cause of cancer-related mortality worldwide due to multi-focal recurrence. We herein identified three major subtypes HCC by performing integrative analysis two omics data sets, clarified that this classification was closely correlated clinicopathological immune profiles recurrence patterns.MethodsIn test study, 183 tumor specimens surgically resected from...
The Brisbane 2000 Terminology for Liver Anatomy and Resections, based on Couinaud's segments, did not address how to identify segmental borders anatomic territories of less than one segment. Smaller resections including segmentectomies subsegmentectomies, have been well defined. advent minimally invasive liver resection has enhanced the possibilities more precise due a magnified view reduced bleeding, (MIALR) is becoming popular gradually. Therefore, there need updating system, segmentectomy...
GVHD (usually fatal) was always caused when either the long or short treatment used for recipients of intestinal grafts and cell suspensions spleen lymph nodes.In contrast, both immunosuppressive protocols allowed engraftment bone marrow cells, liver, heart, kidney without clinical GVHD, whereas thymus small doses whole blood neither engrafted nor GVHD.At 100 days, now drug-free 73 marrow, heart were tolerant in that they accepted all challenge LEW and/or liver more days despite vitro...
ABO-incompatible (ABO-I) living donor liver transplantation (LDLT) has been performed in Japan to overcome the organ shortage. Reported herein are results of this approach through March 2006 National Registry Study Group for transplantation. The questionnaires consisted patient characteristics, operative data, and strategies preventing antibody-mediated rejection (AMR). Data 291 patients (follow-up period, 8 months-15 years; mean, 35 months) from 28 institutions were collected. Age was...
At this time, the only definitive treatment of hepatic failure is liver transplantation. However, transplantation has been limited by severely supply human donor livers. Alternatively, a regenerative medicine approach recently proposed in rodents that describe production three-dimensional whole-organ scaffolds for assembly engineered complete organs. In present study, we decellularization porcine livers to generate constructs at scale can be clinically relevant. Adult ischemic were...
We evaluated the effects of rituximab prophylaxis on outcomes ABO-blood-type-incompatible living donor liver transplantation (ABO-I LDLT) in 381 adult patients Japanese registry ABO-I LDLT. Patients underwent dual or triple immunosuppression with without B cell desensitization therapies such as plasmapheresis, splenectomy, local infusion, intravenous immunoglobulin and rituximab. Era before 2005, intensive care unit-bound status, high Model for End-Stage Liver Disease score absence were...
Laparoscopic pancreaticoduodenectomy (LPD) requires sufficient laparoscopic training for optimal outcomes. Our aim is to determine the learning curve and investigate factors influencing surgical outcomes during curve.We analyzed results of 150 consecutive cases LPD performed by three hepatopancreatobiliary surgeons their 50 first cases. Learning curves were constructed cumulative sum (CUSUM) analysis. Preoperative resection time blood loss investigated in introductory stable periods. RESULTS...
Abstract Background In the absence of randomized controlled data and even propensity-matched data, indications for, outcomes of, laparoscopic repeat liver resection for hepatocellular carcinoma (HCC) remain uncertain. This study aimed to clarify current HCC, evaluate outcomes. Methods Forty-two surgery centres around world registered patients who underwent HCC. Patient characteristics, preoperative function, tumour surgical method, short- long-term were recorded. Results Analyses showed that...
The concept of minimally invasive anatomic liver resection (MIALR) is gaining popularity. However, specific technical skills need to be acquired safely perform MIALR. "Expert Consensus Meeting: Precision Anatomy for Minimally Invasive HBP Surgery (PAM-HBP Consensus)" was developed as a special program during the 32nd meeting Japanese Society Hepato-Biliary-Pancreatic (JSHBPS).Thirty-four international experts gathered online consensus. A Research Committee performed comprehensive literature...
Recent advances in systemic therapy for hepatocellular carcinoma (HCC) have led to debates about the feasibility of combination therapies, such as combined with surgery or transarterial chemoembolization, patients advanced HCC. However, a lack consensus on oncological resectability criteria has hindered discussions "conversion therapy" and optimal management To address this issue, Japan Liver Cancer Association (JLCA) Japanese Society Hepato-Biliary-Pancreatic Surgery (JSHBPS) established...
Importance Preoperative chemo(radio)therapy is increasingly used in patients with localized pancreatic adenocarcinoma, leading to pathological complete response (pCR) a small subset of patients. However, multicenter studies in-depth data about pCR are lacking. Objective To investigate the incidence, outcome, and risk factors after preoperative chemo(radio)therapy. Design, Setting, Participants This observational, international, cohort study assessed all consecutive pathology-proven...
Importance The effect of adjuvant chemotherapy following resection pancreatic adenocarcinoma after preoperative (m)FOLFIRINOX (combination leucovorin calcium [folinic acid], fluorouracil, irinotecan hydrochloride, and oxaliplatin in full or modified dosing) on overall survival (OS) is unclear because current studies do not account for the number cycles regimen. Objective To investigate association with OS, taking into Design, Setting, Participants This retrospective cohort study included...
Heterotopic hamster hearts transplanted to unmodified LEW rats underwent humoral rejection in 3 days. Survival was prolonged a median of 4 days with 2 mg/kg/day FK506. As monotherapy, 15 cyclophosphamide greatly graft survival--far more than could be accomplished RS-61443, brequinar (BQR), mizoribine, methotrexate, or deoxyspergualin. However, when FK506 treatment, which ineffective alone, combined short induction course (14 30 days) subtherapeutic BQR, cyclophosphamide, routine survival...
Background. ABO-incompatible liver transplantation is associated with an extremely complicated postoperative course, especially when the recipients are adults. Methods. Two adult patients underwent living-donor from donors. The antirejection therapy included multiple perioperative plasmapheresis, splenectomy, systemic triple immunosuppressive regimen tacrolimus, methylprednisolone, and cyclophophamide, or azathioprine. In addition to these conventional approaches, we performed intraportal...
In living donor liver transplantation, the safety of operation is highest priority. The introduction right lobe graft was late because concerns about safety. We investigated regeneration by types resected segments as well recipients to assess that appropriate occurring. Eighty-seven donors were classified into 3 groups: left lateral section donors, and donors. Forty-seven adult either or grafted recipients. Volumetry retrospectively performed at 1 week, 1, 2, 3, 6 months, year after...
Patients with pancreatic cancer typically develop tumor invasion and metastasis in the early stage. These malignant behaviors might be originated from stem cells (CSCs), but responsible target is less known about invisible CSCs especially for metastasis. We previously examined proteasome activity of constructed a real-time visualization system human CSCs. In present study, we found that were highly metastatic dominantly localized at invading margins liver model. Microarray siRNA screening...
Dedifferentiation has been implicated in β cell dysfunction and loss rodent diabetes. However, the pathophysiological significance humans remains unclear. To elucidate this, we analyzed surgically resected pancreatic tissues of 26 Japanese subjects with diabetes 11 nondiabetic subjects, who had overweight during adulthood but no family history The diabetic were subclassified into 3 disease stage categories, early, advanced, intermediate. Despite numerical changes endocrine cells...