A5039701558- Endometriosis Research and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Estrogen and related hormone effects
- Renal Diseases and Glomerulopathies
- Drug Transport and Resistance Mechanisms
- Pediatric Urology and Nephrology Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Uterine Myomas and Treatments
- Neonatal Health and Biochemistry
- Pharmacological Effects and Toxicity Studies
- Platelet Disorders and Treatments
- Liver physiology and pathology
- Cancer Genomics and Diagnostics
- Metabolism and Genetic Disorders
- Memory and Neural Mechanisms
- Ovarian function and disorders
- Ovarian cancer diagnosis and treatment
- Assisted Reproductive Technology and Twin Pregnancy
- Radioactive contamination and transfer
- Stress Responses and Cortisol
- Birth, Development, and Health
- Gallbladder and Bile Duct Disorders
- RNA modifications and cancer
Fukushima University
2022-2024
Kyushu University
2024
Kumamoto University
2019-2023
Tokyo Medical and Dental University
2015-2021
National Center For Child Health and Development
2016-2020
Japanese Red Cross Kumamoto Hospital
2015-2016
Queen Mary University of London
2015
Showa General Hospital
2012-2013
RIKEN Center for Computational Science
2009-2012
Yokosuka Kyosai Hospital
2011
Abstract Hepatitis B virus (HBV) is not eradicated by current antiviral therapies due to persistence of HBV covalently closed circular DNA (cccDNA) in host cells and thus development novel culture models for productive infection urgently needed, which will allow the study cccDNA eradication. To meet this need, we developed using human induced pluripotent stem cell-derived hepatocyte lineages, including immature proliferating hepatic progenitor-like cell lines (iPS-HPCs) differentiated...
A quantitative positron emission tomography (PET) methodology was developed for in vivo kinetic analysis of hepatobiliary transport. Serial abdominal PET scans were performed on normal and multidrug resistance-associated protein 2 (Mrp2)-deficient rats after intravenous injection (15<i>R</i>)-16-<i>m</i>-[<sup>11</sup>C]tolyl-17,18,19,20-tetranorisocarbacyclin methyl ester (15<i>R</i>-[<sup>11</sup>C] TIC-Me) as a radiotracer. 15<i>R</i>-[<sup>11</sup>C]TIC-Me rapidly converted to its acid...
P-glycoprotein (P-gp) plays a pivotal role in limiting the penetration of xenobiotic compounds into brain at blood–brain barrier (BBB), where its expression increases with maturation rats. We investigated developmental changes P-gp function BBB nonhuman primates using PET <i>R</i>-<sup>11</sup>C-verapamil, radiotracer useful for evaluating function. In addition, <sup>11</sup>C-oseltamivir, substrate P-gp, was as practical examples. <b>Methods:</b> studies infant (age, 9 mo), adolescent 24–27...
Aromatase (an enzyme that converts androgens to estrogens) in the brain is involved neuroprotection, synaptic plasticity, and regulation of sexual emotional behaviors. To investigate physiologic pathologic importance aromatase brain, including humans, we here report development a novel PET probe for aromatase, <sup>11</sup>C-cetrozole, which allows noninvasive quantification expression. <b>Methods:</b><sup>11</sup>C-cetrozole was synthesized by C-<sup>11</sup>C-methylation method developed...
For intermediate hepatocellular carcinoma (HCC), transcatheter arterial chemoembolization (TACE) therapy is recommended in the guidelines as a monotherapy, although TACE non-curative therapy. The aims of present study were to evaluate efficacy adding radiofrequency ablation (RFA) patients with HCC, and identify factors that associated favorable survival these patients.Fifty-nine HCC enrolled this retrospective study. Thirty-nine treated alone 20 additional RFA after TACE.The recurrence-free...
The common marmoset (Callithrix jacchus) is unique among the primates in its small body size, reproductive efficacy, and characteristic social behavior, making it useful as an animal model neuroscientific research. To assess brain serotonergic systems, we investigated binding of [(11)C]-3-amino-4-(2-dimetylaminomethyl-phenylsulfanyl)-benzonitrile ([(11)C]DASB) to serotonin transporter (SERT) conscious marmosets using positron emission tomography (PET), compared with findings for rhesus...
Reaction of [PdCl2(cod)] with a tetraphosphine, meso-bis[((diphenylphosphino)methyl)phenylphosphino]methane (dpmppm), afforded the mononuclear PdII complexes [PdCl(dpmppm-κ3)]X (X = Cl (1a), PF6 (1b)); pincer-type dpmppm ligand coordinates to Pd atom two outer and one inner phosphorus form fused six- four-membered chelate rings. The remaining phosphine is uncoordinated readily reacts [Cp*MCl2]2 give heterodimetallic [PdCl(Cp*MCl2)(μ-dpmppm-κ3,κ1)]X Cl, M Rh (21a), Ir (21b); X PF6, (23a),...
SARS-CoV-2 infection alters cellular RNA content. Cellular RNAs are chemically modified and eventually degraded, depositing nucleosides into extracellular fluids such as serum urine. Here we searched for COVID-19-specific changes in nucleoside levels contained urine of 308 COVID-19 patients using liquid chromatography-mass spectrometry (LC-MS). We found that two nucleosides, N6-threonylcarbamoyladenosine (t6A) 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A), were elevated patients....
Tumor markers have proved to be generally useful for diagnosing and monitoring malignancy. In contrast, high levels of tumor disturb us differing benign disease from We had 5 cases with who showed values (CA 125 CA 19–9). this report, we illustrated 3 patients endometriosis 2 dermoid cyst 19–9. It was impossible rule out malignant in all preoperatively. ovarian tumors, bimanual examination, ultrasound, CT scan should considered.
Pd(0)-mediated rapid couplings of CH(3)I (and then [(11)C]CH(3)I) with excess 5-tributylstannyl-2'-deoxyuridine and -4'-thio-2'-deoxyuridine were investigated for the syntheses [methyl-(11)C]thymidine its stable analogue, 4'-[methyl-(11)C]thiothymidine as PET probes cancer diagnosis. The previously reported conditions attempted using Pd(2)(dba)(3)/P(o-CH(3)C(6)H(4))(3) (1 : 4 in molar ratio) at 130 °C 5 min DMF, giving desired products only 32 30% yields. Therefore, we adapted current...
Aim Sofosbuvir (SOF) and ribavirin (RBV) combination therapy produces a sustained response in many patients with genotype 2 chronic hepatitis C. However, RBV‐induced anemia is troublesome side‐effect that may limit this treatment. Genetic variation leading to inosine triphosphatase (ITPA) deficiency known protect against hemolytic anemia. This study aimed evaluate the relationships between efficacy safety of SOF/RBV treatment ITPA gene variants. Methods Ninety C treated were studied. The...
<b><i>Background:</i></b> The risk factors associated with the development of hepatocellular carcinoma (HCC) in nonalcoholic fatty liver disease (NAFLD) are still unclear. aim present study was to identify such NAFLD patients who developed HCC. <b><i>Methods:</i></b> Between April 2000 and December 2016, a total 182 were enrolled this study; these, only 22 had To factors, univariate multivariate analyses performed. other than degree fibrosis,...
Abstract WDR19 has been reported as a causative gene of nephronophthisis‐related ciliopathies. Patients with mutations can show various extrarenal manifestations such skeletal disorders, Caroli disease, and retinal dystrophy, typically display nephronophthisis renal phenotype. However, there is limited information on the phenotypes patients mutations. We report two Japanese infants Sensenbrenner syndrome caused by who demonstrated different features in ultrasound histopathological results,...
Aromatase is a rate-limiting enzyme for estrogen biosynthesis and has been implicated in pathophysiological states of various diseases via production. This known to be widely distributed extragonadal gonadal tissues including the stomach. In contrast circulating estrogen, functional role gastric aromatase/estrogen not elucidated detail, because there no efficient methodology investigate spatiotemporal changes vivo. Recently,...
Single nucleotide polymorphisms (SNPs) within or near interferon lambda 4 ( IFNL4 ) gene located upstream of IFNL3 are associated with response to anti‐HCV therapy both in (IFN)‐based and IFN‐free regimens. encodes IFNλ4, a newly discovered type III IFN, its expression is controlled by rs368234815‐TT/ΔG, which strong linkage disequilibrium (LD) other tag SNPs such as rs12979860 rs8099917. Intrahepatic levels IFN‐stimulated genes (ISGs) affect the responsiveness IFNα also genotype. However,...