A5070039319- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Gastric Cancer Management and Outcomes
- T-cell and B-cell Immunology
- Cancer Treatment and Pharmacology
- Immune Cell Function and Interaction
- Esophageal and GI Pathology
- Renal Diseases and Glomerulopathies
- Cancer Diagnosis and Treatment
- IL-33, ST2, and ILC Pathways
- Pancreatic and Hepatic Oncology Research
- Multiple and Secondary Primary Cancers
- Crystallization and Solubility Studies
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Renal and related cancers
- Pediatric Urology and Nephrology Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Chronic Kidney Disease and Diabetes
- Gastrointestinal disorders and treatments
- X-ray Diffraction in Crystallography
- Sarcoma Diagnosis and Treatment
- Dialysis and Renal Disease Management
- Chemotherapy-related skin toxicity
- Genetic and Kidney Cyst Diseases
Kyoto University
1986-2025
Ogikubo Hospital
2013-2024
Teikyo University
2024
RIKEN Center for Integrative Medical Sciences
2023
Creative Commons
2023
RIKEN Center for Advanced Intelligence Project
2023
National Center For Child Health and Development
2016-2021
Keio University
2007-2017
Kurashiki Central Hospital
2015
Tenri Hospital
2011
We demonstrate the generation of alternating spin current (SC) via spin-rotation coupling (SRC) using a surface acoustic wave (SAW) in Cu film. Ferromagnetic resonance caused by injecting SAWs was observed Ni-Fe film attached to film, with further found be suppressed through insertion SiO_{2} into interface. The intensity depended on angle between vector SAW and magnetization This angular dependence is explicable terms presence transfer torque from SC generated SRC.
Tertiary lymphoid tissues (TLTs) facilitate local T and B cell interactions in chronically inflamed organs. However, the cells molecular pathways that govern TLT formation are poorly defined. Here, we identified TNF superfamily CD153/CD30 signaling between 2 unique age-dependent lymphocyte subpopulations, CD153+PD-1+CD4+ senescence-associated (SAT) CD30+T-bet+ age-associated (ABCs), as a driver for expansion. SAT cells, which produced ABC-inducing factors IL-21 IFN-γ, ABCs progressively...
Significance Statement Ectopic lymphoid structures called tertiary tissues (TLTs) develop in several kidney diseases and are associated with poor renal prognosis. However, the mechanisms underlying TLT expansion their effect on regeneration remain unclear. The authors report that single-nucleus RNA sequencing validation experiments demonstrate TLTs potentially amplify inflammation aged injured kidneys. Lymphocytes within promote proinflammatory phenotypes of surrounding proximal tubules...
Tertiary lymphoid tissues (TLTs) are ectopic structures induced by multiple stimuli, including infection and tissue injuries; however, their clinical relevance in disease progression has remained unclear. We demonstrated previously that TLTs develop mouse human kidneys with aging can be a potential marker of kidney injury prognosis, therapeutic targets. In addition, we found two types unique lymphocytes emerge aging, senescence-associated T cells age-associated B cells, essential for TLT...
Chronic kidney disease is a global health problem with high morbidity and mortality rates. Acute injury substantially increases the risk of chronic progression, particularly in elderly, partly because prolonged inflammation that exacerbates fibrosis dysfunction. Tertiary lymphoid structures (TLSs) are ectopic aggregates develop non-lymphoid organs during inflammation, such as autoimmune diseases, cancers, age-related inflammation. Age-dependent TLS formation observed various organs, kidneys,...
While epidemiological and experimental studies have demonstrated kidney-protective effects of estrogen female sex in adulthood, some data showed deterioration kidney function during puberty when production increases. However, molecular mechanisms explaining these conflicting phenomena remain unknown. Here, we that the pubertal hormone surge mice increases susceptibility to ischemia reperfusion injury partly via downregulation insulin-like growth factor 1 receptor (IGF-1R) expression proximal...
Abstract WDR19 has been reported as a causative gene of nephronophthisis‐related ciliopathies. Patients with mutations can show various extrarenal manifestations such skeletal disorders, Caroli disease, and retinal dystrophy, typically display nephronophthisis renal phenotype. However, there is limited information on the phenotypes patients mutations. We report two Japanese infants Sensenbrenner syndrome caused by who demonstrated different features in ultrasound histopathological results,...
Abstract Background Despite advances in non‐invasive vascular imaging, detection of renal artery stenosis via catheter angiography is the criterion standard for diagnosis renovascular hypertension (RVH). However, because lack evidence, utility various blood tests and imaging modalities remains unclear. Methods We retrospectively analyzed (plasma renin activity [PRA], aldosterone, vein [RVR] values) studies (computed tomography [CTA], kidney ultrasonography [US]) by comparing them with...
Bordetella pertussis infection is a known trigger of atypical hemolytic uremic syndrome (HUS). For patients suspected having HUS, prompt plasma exchange/infusion (PE/PI) or eculizumab (ECZ) treatment recommended. We report 1-month-old female infant who was admitted with severe cough and B. pertussis-positive sputum culture. She born at 38 weeks gestation did not have family history renal diseases. Hemophagocytic she transferred to our hospital 17 days after her initial admission. One day...
Transanal rectal foreign bodies are items retained in the rectum following direct insertion through anus. In general, treatment strategy is to attempt endoscopic removal of body At our hospital, there were 4 cases during 4-year period from April 2010 March 2014, and removed endoscopically all cases. All patients male, with a median age 22.5 years (16 87 years) . Their motives for sexual preference 2 cases, amusement 1 case, habitual practice induce defecation case. The found vibrators...
Locally advanced right-sided colon cancer sometimes requires procedures in addition to normal complete mesocolic excision. We describe laparoscopic right hemicolectomy with gastrocolic trunk (GCT) resection. A 48-year-old woman was diagnosed transverse and severe lymph node metastasis. Bulky nodes were contact the superior mesenteric vein (SMV) that invaded root of GCT. Curative GCT resection performed. performed using both cranial caudal approaches. First, we ligated distal side from...
Children with systemic lupus erythematosus (SLE) generally undergo a pretreatment kidney biopsy. However, some of these patients, especially those antiphospholipid syndrome (APS), may experience serious coagulopathic complications. We report herein two cases paediatric SLE APS in which, despite normal blood test results, the disparate complications haemorrhage and embolism developed following Case 1 was, an 8-year-old male whom, primary was initially diagnosed. Fourteen months later Based on...